DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and Papln

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	723	Identity:	191/723 - (26%)
Similarity:	283/723 - (39%)	Gaps:	199/723 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            |..|.:||.|||:||||:.::.|.|.::     .:....:|||..:.::.|:...|.:...||||
Mouse    30 WGTWGEWSPCSRTCGGGISFRERPCYSQ-----RRDGGTSCVGPARSHRTCHTESCPDGVRDFRA 89

  Fly   247 SQCSAYNDKEFHGHRYRWEPYVKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFW 311
            .||:.::..:|.|.||||.||.....:|||||:|.|...:....::|:||||| .|.
Mouse    90 EQCAEFDGTDFQGRRYRWLPYYAAPNKCELNCIPKGQNFYYKHKDAVVDGTPC-EPG-------- 145

  Fly   312 ERAVCVDGACKAVQASGEIDGLYAHSGSVSCG--GLLCRPVTGIFTRNPLPEHAYIHVTTLPVGA 374
            :|.:||||.|:.|....::|.:......:.||  |..|.||||.|..|.| ...|..:..:|.||
Mouse   146 QRDICVDGVCRVVGCDHKLDSIKQEDKCLQCGGDGSSCYPVTGTFDGNDL-SRGYNQIFIIPAGA 209

  Fly   375 SNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWITS 439
            ::|.|.|...|.|.|.:::.......||..|:..:.:......|..|.|  |.| .:...|.:.:
Mouse   210 TSIRIEEAAASRNFLAVKSIRGEYYLNGHWTIEAAQALPVASTVLQYER--GVE-GDLAPERLQA 271

  Fly   440 IGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGR 504
            .||..:.|.:.:.::. :|.||.|||.||                              ::..||
Mouse   272 RGPTSEPLVIELLSQE-SNPGVHYEYYLP------------------------------ANDPGR 305

  Fly   505 KRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPA 569
            .  |:|....:..|:..||||.|:.::.|...|  ..|....|.|..:|....:   |||||||.
Mouse   306 G--FSWSHGSWGDCSAECGGGHQSRLVFCTIDN--EAYPDHMCQHQPRPTHRRS---CNTQPCPK 363

  Fly   570 ------------------------YWRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAA 610
                                    .|:...|..|..|..||::.|.|.|:....:|.....::..
Mouse   364 TKRISFLHRPGAWRYAGVQHMCGNSWKVGPWTPCSVSCGGGVQSRSVYCISSDGTGGQEAAEETQ 428

  Fly   611 C--MEDQPPMQKQCECPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYC 673
            |  :..:||..:.|        ||..                          .|:|.|..|.: |
Mouse   429 CAGLVGKPPTTQAC--------NLQH--------------------------CAVWSVEPWGE-C 458

  Fly   674 SVTCGSGVEYRTVFCDRSKAGEQRCDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRT 738
            |||||:|:..|:|.| |...|.             |....||.|.|..|            ||..
Mouse   459 SVTCGTGIRKRSVTC-RGDEGS-------------PVHAAACLLKDQPT------------LTEP 497

  Fly   739 REVLCIRSQLITEHSECTPELKPQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSV--- 800
                |::        |..|..:.|:               ||...||.|:|.||.|.:||.|
Mouse   498 ----CVQ--------EACPVFRGQA---------------WHVGSWSLCSKSCGSGIRRRQVVCT 535

  Fly   801 -----RCLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKT-----------EVTPVCAD 849
                 ||:  |::.:...|...|   ||:|.:....|.:..: |:|           .|:||...
Mouse   536 IGPPGRCV--DLQSSKPAEMEAC---NRQPCHLPQEVPSIQD-PRTRSSDPRMLSGPRVSPVSDG 594

  Fly   850 KFSNCQWA 857
            :  ..|||
Mouse   595 R--EQQWA 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	17/55 (31%)
		ADAM_spacer1	348..468	CDD:283607	35/119 (29%)
		TSP1	667..716	CDD:214559	15/48 (31%)
		TSP1	779..835	CDD:214559	21/63 (33%)
		PLAC	847..877	CDD:285849	3/11 (27%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559	17/55 (31%)
		ADAM_spacer1	184..299	CDD:368694	35/119 (29%)
		TSP1	309..362	CDD:214559	18/57 (32%)
		TSP1	389..447	CDD:214559	16/91 (18%)
		TSP1	447..504	CDD:214559	26/95 (27%)
		TSP1	511..562	CDD:214559	20/55 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648		9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924
		Papilin_u7	831..922	CDD:374683
		Ig	932..>995	CDD:386229
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064
		I-set	1070..1141	CDD:369462
		Ig	1157..1241	CDD:386229
		PLAC	1257..1289	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910