DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and Adamts13

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_006233941.3	Gene:	Adamts13 / 102554393	RGDID:	1311594	Length:	1482	Species:	Rattus norvegicus

Alignment Length:	850	Identity:	199/850 - (23%)
Similarity:	306/850 - (36%)	Gaps:	221/850 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            |..|...|.|||||||||..:.|.|.|    ........||||...:.::||...|::...:|.:
  Rat   449 WSSWGPHSPCSRSCGGGVITRRRWCNN----PRPAFGGRACVGEDLQAKMCNTQACEKTQLEFMS 509

  Fly   247 SQCSAYNDK------EFHGHRYRWE---PYVKDDAECELNCMPFGMKSFATLNESVIDGTPC--G 300
            .|| |..|:      :.....|.|:   .|.:.|..|...|...|.....:..:|.:|||.|  .
  Rat   510 EQC-AQTDRHPLQLSQGSASFYHWDAAVQYSQGDTLCRHMCWAVGESFIVSRGDSFLDGTRCVPN 573

  Fly   301 HPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCGG--LLCRPVTGIFTRNPLPEHA 363
            .|.|     ....::|:.|:|:.....|::|..........|||  ..|....|.||.....|:.
  Rat   574 GPRE-----DGTVSLCLLGSCRTFGCDGKMDSQQVWDACQVCGGDNSTCTSQNGSFTAGRAREYV 633

  Fly   364 YIHVTTLPVGASNISITELKNSINL---LVLRTSNELAIFNGENTVSESGSYEAVGAVFDY---H 422
            ...:.|     .|::...:.|...|   |.:|..:.. |.:|::::|.:.:|.::  :.||   :
  Rat   634 TFLIVT-----PNMTSAHVINHRPLFTHLAVRIQDHY-IVSGKSSMSPNVTYPSL--LEDYRVEY 690

  Fly   423 RIDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTG------VKYEY-----MLPIVSESEEN 476
            |:...||.....|.|...||:||.:::.|:.:.....|      :.:.|     ....|..::..
  Rat   691 RVTLTEDQLPRLEEIHIRGPVRDDIEIQVYRRYGGEYGGLTHPDITFTYFQRKQQAAWVWAAKRG 755

  Fly   477 EMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFN------------------------WKVIGFSS 517
            ..|:...     :|:...:.|...:|..|.:.|                        |....|..
  Rat   756 PCSVSCG-----AGLRWVTYSCQDQAQNKWVRNAQCQGSPQPPAWQEPCVSAPCPPHWVADDFGP 815

  Fly   518 CTKSCGGGTQTPIIRCIRKN----------PLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWR 572
            |:.|||||.:...:||:..:          |.|..:|:.....      ||   ||:||||..|.
  Rat   816 CSVSCGGGLRERSLRCVEAHNGFLKTLPPAPCRAVAQQPAGEV------EN---CNSQPCPTGWE 871

  Fly   573 FDDWGECRCSS-SGGLRRREVSCVQELASGLVIHVDKAA----CM-EDQPPMQKQC---ECPKNR 628
            ..|...|..|: ..||.....:||..:...     :|.|    |. :|..|:.:.|   .|...
  Rat   872 VSDPSPCVSSACEPGLESGSGTCVPRVGDS-----EKPAMAGPCRPDDMSPVPEPCVRTTCSPG- 930

  Fly   629 RRNLSRYRLSGPSESSS----NSSQVKRSKIDGSDATAIW--LVSDWNQYCSVTCGSGVEYRTVF 687
                     |||.::.|    .||.|...| ..|.|..:|  ||.    .||::||.|::.....
  Rat   931 ---------SGPVDTMSLGEEASSPVGSGK-PSSQAEHVWTPLVG----LCSISCGKGLKELYFL 981

  Fly   688 CDRS----KAGEQRCDPSTTPESR------RPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVL 742
            |..|    ...|:.|..::.|.||      |||  ||    .|.|...:.|...|........:.
  Rat   982 CMDSVLKMPVQEELCGLASKPPSRWEVCRARPC--PA----RWETRVLAPCPVTCGGGRVPLAIH 1040

  Fly   743 CIR----SQLITEHSECTPELKPQSVEKCSHE--------------------------------- 770
            |::    ..:...||:|.|..:|.|.|.||.|
  Rat  1041 CVQLDHGRPVSVPHSKCWPAPRPGSFEDCSPEPCPARWKVLPLGPCSASCGLGTATQMVACVQLD 1105

  Fly   771 -----EVEY-------------------CAARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNA 811
                 ||:.                   ||.|||.|.|:||:..||.|.|||...||....::..
  Rat  1106 QGHDNEVDETFCKALVRPPASVPCLIADCAYRWHISTWTECSVSCGDGIQRRHGTCLGPQAQVPV 1170

  Fly   812 LRESTHCRYTNREPIYRNCNVQACA------EVPKTEVT----PVCADKFSNCQWASQAKLCSYD 866
              .:..|::..:....|.|....||      .:|..|.|    .:.|...::.|| ||.:..::.
  Rat  1171 --PANFCQHLPKPVTVRGCWAGPCAGQKISSSLPHKEATLPSQTLAAVTAASLQW-SQPQAQAHS 1232

  Fly   867 YYRDN 871
            .:.|:
  Rat  1233 LFPDS 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	21/55 (38%)
		ADAM_spacer1	348..468	CDD:283607	28/136 (21%)
		TSP1	667..716	CDD:214559	17/58 (29%)
		TSP1	779..835	CDD:214559	17/55 (31%)
		PLAC	847..877	CDD:285849	6/24 (25%)
Adamts13	XP_006233941.3	ZnMc_ADAMTS_like	139..345	CDD:239801
		ADAM_CR_2	363..433	CDD:407643
		TSP1	449..501	CDD:214559	21/55 (38%)
		TSP1_ADAMTS	755..804	CDD:408800	6/53 (11%)
		TSP1_ADAMTS	808..866	CDD:408800	18/66 (27%)
		TSP1_ADAMTS	960..1014	CDD:408800	16/57 (28%)
		TSP1_ADAMTS	1018..1074	CDD:408800	15/55 (27%)
		TSP1_ADAMTS	1078..1134	CDD:408800	2/55 (4%)
		TSP1_ADAMTS	1138..1192	CDD:408800	17/55 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910