Protein Alignment loh and adamts17

DIOPT Version :10

• Sequence 1: NP_609406.2
• Gene: loh / 34435
• FlyBaseID: FBgn0032252
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: XP_073764157.1
• Gene: adamts17 / 101884120
• ZFINID: ZDB-GENE-121030-7
• Length: 1134
• Species: Danio rerio
• Alignment Length: 771
• Identity: 192/771 - (24%)
• Similarity: 291/771 - (37%)
• Gaps: 204/771 - (26%)

  Fly   159 NPPQEATSSTSKK---AKKKV--YPYPR-----WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLT 213
            :||.:.|...:.|   |.:.|  .|.|:     |..||.||.|||:||.|.:::.|||.|.....
Zfish   503 DPPLDGTECGADKWCRAGECVSKTPIPQHVDGDWSPWSTWSMCSRTCGTGARFRQRKCDNPPPGP 567

  Fly   214 NNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPYVKDDAECELNC 278
            ..:....|.|    .:::|...||.:..|.||..||.:: :::.......|...:.|:..|.|.|
Zfish   568 GGKYCQKASV----EHKVCEGPPCTKGLPTFRDQQCQSH-ERQASKKSQMWTAVIDDEKPCALYC 627

  Fly   279 MPFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVS-C 342
            .|.|..|...:.|.|:||||||.         :|..:||:|.|:.:..    ||:...|.... |
Zfish   628 TPVGSDSPVLVAERVLDGTPCGP---------YESDLCVNGKCQKIGC----DGIIGSSAKEDRC 679

  Fly   343 G-----GLLCRPVTGIF--TRNPLPE---------------------HAYIHVTTLPVGASNISI 379
            |     |..||.:.|.|  ::..:|.                     ..||....:||||..|.:
Zfish   680 GVCNGDGKSCRIIKGDFNHSKGMVPHSLCKKVSTCVMSKPRAVLKCFSCYIEAAVIPVGARRIKV 744

  Fly   380 TELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIR 444
            .|.|.|.:.|.|:.|::.:| |.:..:...|.:|..|....|.|       .|:.|.:::.||.:
Zfish   745 VEDKPSHSFLALKDSSKRSI-NNDWKIELPGEFELAGTTVRYVR-------RGLWEKMSAKGPTK 801

  Fly   445 DSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFN 509
            ..|.|||........|:.|||.:.: :.|:||     ||| |::.              .:.::.
Zfish   802 TPLHLMVLLFHDQTYGIHYEYTVAL-NHSQEN-----SSD-LVKE--------------PEHMYL 845

  Fly   510 WKVIGFSSCTKSCGGGTQTPIIRCIR--KNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWR 572
            |....:..|:..||||.:..::.|:|  ...:...:...|....||  :..:..||..||...|.
Zfish   846 WTHSSWEDCSVHCGGGERRTVVSCMRIINKTMTPVNDSSCQVENKP--SPQIRQCNIHPCQYRWV 908

  Fly   573 FDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQCECPKNRRRNLSRYRL 637
            ..||.:|..:...||::|||.|:.:|.:|..|......|:..:|...:.||
Zfish   909 TGDWTQCSLTCGKGLQQREVGCIYQLQNGTYIPTRDLYCLSSKPASVQHCE-------------- 959

  Fly   638 SGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRSKAGEQRCDPST 702
                               |.....:|..|:|:| ||..||.|...|||.|.....   .|||.:
Zfish   960 -------------------GRHCLTVWEASEWSQ-CSSECGHGSRRRTVTCTNPHG---LCDPVS 1001

  Fly   703 TPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLCIRSQLITEHSECTPELKPQSVEKC 767
                 ||.|..|||                                  :||:|
Zfish  1002 -----RPAEVEACE----------------------------------DHSKC------------ 1015

  Fly   768 SHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREPIYRNCNV 832
                     ..|...:||:|:..||.|.|.|.|:|:.   :::. |..:.|....:...||.|:.
Zfish  1016 ---------YEWKTGEWSKCSSSCGRGLQSRVVQCMH---RVSG-RHGSDCPAVLKPATYRQCHQ 1067

  Fly   833 QAC---AEVPKTEVTPVCADKFSNC---QWASQAK------LCSYDYYRDNCCFSC 876
            ..|   ..: .|..:|..|.....|   |||...|      ||....:...||.:|
Zfish  1068 STCNARGNI-NTITSPRLAALTYKCVGDQWAVYCKVIREKNLCQDMRWYQRCCQTC 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	19/55 (35%)
		ADAMTS_spacer1	349..468	CDD:461796	35/141 (25%)
		TSP1_ADAMTS	510..567	CDD:465950	13/58 (22%)
		TSP1_ADAMTS	664..715	CDD:465950	19/50 (38%)
		TSP1_ADAMTS	720..768	CDD:465950	3/47 (6%)
		TSP1_ADAMTS	779..835	CDD:465950	16/55 (29%)
		PLAC	847..877	CDD:462560	11/39 (28%)
adamts17	XP_073764157.1	None