DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and adamts17

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_021333385.1	Gene:	adamts17 / 101884120	ZFINID:	ZDB-GENE-121030-7	Length:	1134	Species:	Danio rerio

Alignment Length:	771	Identity:	193/771 - (25%)
Similarity:	291/771 - (37%)	Gaps:	204/771 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 NPPQEATSSTSKK---AKKKV--YPYPR-----WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLT 213
            :||.:.|...:.|   |.:.|  .|.|:     |..||.||.|||:||.|.:::.|||.|.....
Zfish   503 DPPLDGTECGADKWCRAGECVSKTPIPQHVDGDWSPWSTWSMCSRTCGTGARFRQRKCDNPPPGP 567

  Fly   214 NNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPYVKDDAECELNC 278
            ..:....|.|    .:::|...||.:..|.||..||.:: :::.......|...:.|:..|.|.|
Zfish   568 GGKYCQKASV----EHKVCEGPPCTKGLPTFRDQQCQSH-ERQASKKSQMWTAVIDDEKPCALYC 627

  Fly   279 MPFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVS-C 342
            .|.|..|...:.|.|:||||||.         :|..:||:|.|:.:..    ||:...|.... |
Zfish   628 TPVGSDSPVLVAERVLDGTPCGP---------YESDLCVNGKCQKIGC----DGIIGSSAKEDRC 679

  Fly   343 G-----GLLCRPVTGIF--TRNPLPE---------------------HAYIHVTTLPVGASNISI 379
            |     |..||.|.|.|  ::..:|.                     ..||....:||||..|.:
Zfish   680 GVCNGDGKSCRIVKGDFNHSKGMVPHSLCKKVSTCVMSKPRAVLKCFSCYIEAAVIPVGARRIKV 744

  Fly   380 TELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIR 444
            .|.|.|.:.|.|:.|::.:| |.:..:...|.:|..|....|.|       .|:.|.:::.||.:
Zfish   745 VEDKPSHSFLALKDSSKRSI-NNDWKIELPGEFELAGTTVRYVR-------RGLWEKMSAKGPTK 801

  Fly   445 DSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFN 509
            ..|.|||........|:.|||.:.: :.|:||     ||| |::.              .:.::.
Zfish   802 TPLHLMVLLFHDQTYGIHYEYTVAL-NHSQEN-----SSD-LVKE--------------PEHMYL 845

  Fly   510 WKVIGFSSCTKSCGGGTQTPIIRCIR--KNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWR 572
            |....:..|:..||||.:..::.|:|  ...:...:...|....||  :..:..||..||...|.
Zfish   846 WTHSSWEDCSVHCGGGERRTVVSCMRIINKTMTPVNDSSCQVENKP--SPQIRQCNIHPCQYRWV 908

  Fly   573 FDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQCECPKNRRRNLSRYRL 637
            ..||.:|..:...||::|||.|:.:|.:|..|......|:..:|...:.||
Zfish   909 TGDWTQCSLTCGKGLQQREVGCIYQLQNGTYIPTRDLYCLSSKPASVQHCE-------------- 959

  Fly   638 SGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRSKAGEQRCDPST 702
                               |.....:|..|:|:| ||..||.|...|||.|.....   .|||.:
Zfish   960 -------------------GRHCLTVWEASEWSQ-CSSECGHGSRRRTVTCTNPHG---LCDPVS 1001

  Fly   703 TPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLCIRSQLITEHSECTPELKPQSVEKC 767
                 ||.|..|||                                  :||:|
Zfish  1002 -----RPAEVEACE----------------------------------DHSKC------------ 1015

  Fly   768 SHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREPIYRNCNV 832
                     ..|...:||:|:..||.|.|.|.|:|:.   :::. |..:.|....:...||.|:.
Zfish  1016 ---------YEWKTGEWSKCSSSCGRGLQSRVVQCMH---RVSG-RHGSDCPAVLKPATYRQCHQ 1067

  Fly   833 QAC---AEVPKTEVTPVCADKFSNC---QWASQAK------LCSYDYYRDNCCFSC 876
            ..|   ..: .|..:|..|.....|   |||...|      ||....:...||.:|
Zfish  1068 STCNARGNI-NTITSPRLAALTYKCVGDQWAVYCKVIREKNLCQDMRWYQRCCQTC 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	19/55 (35%)
		ADAM_spacer1	348..468	CDD:283607	37/142 (26%)
		TSP1	667..716	CDD:214559	19/48 (40%)
		TSP1	779..835	CDD:214559	16/55 (29%)
		PLAC	847..877	CDD:285849	11/39 (28%)
adamts17	XP_021333385.1	Pep_M12B_propep	33..170	CDD:307618
		ZnMc_ADAMTS_like	223..439	CDD:239801
		TSP1	536..587	CDD:214559	18/54 (33%)
		ADAM_spacer1	729..824	CDD:310520	32/102 (31%)
		TSP1	907..>931	CDD:214559	9/23 (39%)
		TSP1	966..1013	CDD:214559	22/89 (25%)
		TSP1	1018..1070	CDD:214559	16/55 (29%)
		PLAC	1099..1123	CDD:312271	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910