Protein Alignment loh and adamtsl3

DIOPT Version :10

• Sequence 1: NP_609406.2
• Gene: loh / 34435
• FlyBaseID: FBgn0032252
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: XP_003198947.5
• Gene: adamtsl3 / 100534944
• ZFINID: ZDB-GENE-121030-8
• Length: 1759
• Species: Danio rerio
• Alignment Length: 868
• Identity: 198/868 - (22%)
• Similarity: 320/868 - (36%)
• Gaps: 270/868 - (31%)

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            ||.|..||.|||:||||..|.:|:|:|          ...|.|...||:.|::..|..:|.||||
Zfish    78 WDAWGTWSDCSRTCGGGASYSLRRCLN----------GGNCEGRNIRYRTCSNTDCPLESGDFRA 132

  Fly   247 SQCSAYNDKEFHGHRYRWEPYVKDD-AECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQF 310
            .||||:||.::.|..|.|.|...|. :.|.|.|...|......|...|:|||.|
Zfish   133 QQCSAHNDIKYQGQTYEWIPVTYDPISPCALRCQARGKGQVVELAPKVLDGTRC----------- 186

  Fly   311 WERA----VCVDGACKAVQASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTRNPLPEHAYIH 366
              :|    :|:.|.|:.|....:   |.:::...:||     |..||.:.|....:..||.....
Zfish   187 --KADSLDMCISGICQEVGCDRQ---LGSNAKEDNCGVCAGDGSTCRLIRGQALPHVSPEEPIKT 246

  Fly   367 VTTLPVGASNISITELKNSINLLVLRTSNELAIFNGENT------VSESGSYEAVGAVFDYHRID 425
            |..:|:|:..:.||  ....:::|:..       :|:|:      .|.|||:.......::.|
Zfish   247 VIEVPMGSRGLRIT--AKGPDMIVIEA-------HGQNSRREEVHFSSSGSHSLGNNTVEFQR-- 300

  Fly   426 GAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEM-----------S 479
            |||     .:.:...||:.....:.|......:|.:::.:..||..:..|.:.           .
Zfish   301 GAE-----RQTLRCYGPLTADFTVKVKYAGPKDTVIQFMFYQPIRYQWRETDFFPCSVTCGGGYQ 360

  Fly   480 LESSD------------GLLRSGMEDTSSSSSSRA----------GRKRIF---------NWKVI 513
            |.|:|            .|..|..|:|..:...:.          |.|.:.         .|:..
Zfish   361 LNSADCVDIRYNRSVAEHLCHSFPENTKPTPKLKECNMEPCPESDGFKEVMPYDHFQPLPRWEQN 425

  Fly   514 GFSSCTKSCGGGTQTPIIRCIRKN---PLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDD 575
            .::||:.|||||:|...|.|:.::   .:......:||||.:|:..:|   |||..|| .|...:
Zfish   426 PWTSCSVSCGGGSQERSIVCVEEDVHGQIVQVEDWKCTHSPRPISKQN---CNTFDCP-QWMAME 486

  Fly   576 WGECRCSSSGGLRRREVSCVQ---ELASGLVIHVDKAACMEDQPPMQKQC----ECPKNRRRNLS 633
            |.:|..:...|||.|.|.||.   :.|.|...|:        :|.:::.|    .|.|.|...
Zfish   487 WSQCTVTCGPGLRYRVVLCVDYNGQHAGGCNPHL--------KPHIKEDCLVPIACHKPRENQ-- 541

  Fly   634 RYRLSGPSESS----SNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFC------ 688
                  |.|:.    ..:.:::.:|:...|.|  ::...|:. |||:||.|::.|.|.|
Zfish   542 ------PVEAKLPWLKQAQELEETKVALEDPT--FVPEPWSS-CSVSCGLGIQRRQVKCKVLLSF 597

  Fly   689 -------------DRSKAGEQRCDPS---TTPESRRPCEKP--------------------ACEL 717
                         :...:.::.||..   ..|:||.|...|                    :|.:
Zfish   598 TQAEVELPDEECHEEKPSSQRSCDSGPCLAAPDSRWPLRTPEGPNQHGYAWEYIGFTACSASCAV 662

  Fly   718 GD------------------------------------------WFTGPWSSCNGDCFDLTRTRE 740
            |.                                          |....|:.|:..|....:||.
Zfish   663 GKQMAVVRCVNTLKKEIVDDLLCNGSKAPVSLLRICNPQPCPPRWEVSVWNLCSVSCGVGLQTRS 727

  Fly   741 VLCIRSQL--ITE---HSECTPELKPQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSV 800
            |.|:||..  .||   ..:|..: :|..::.|:...   |...|...:|.:|:..||.|:|.|.|
Zfish   728 VSCVRSVAGNRTESLSSKDCVGK-RPNELQACNQVA---CPPSWEAEEWQQCSHSCGRGSQWRKV 788

  Fly   801 RCLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFSNC--------QWA 857
            .|.:        |.:|..        ||....:.|.. ||.:|..:|.:  ::|        :|:
Zfish   789 YCKQ--------RLATGS--------YRRLKDEDCTG-PKPDVHRICTN--ADCLLPRLEGGEWS 834

  Fly   858 SQAKLCSYDYYRDNCCFSCTGGI 880
                         .|..:|..|:
Zfish   835 -------------KCSVTCGKGV 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	21/55 (38%)
		ADAMTS_spacer1	349..468	CDD:461796	23/124 (19%)
		TSP1_ADAMTS	510..567	CDD:465950	20/59 (34%)
		TSP1_ADAMTS	664..715	CDD:465950	17/92 (18%)
		TSP1_ADAMTS	720..768	CDD:465950	14/52 (27%)
		TSP1_ADAMTS	779..835	CDD:465950	14/55 (25%)
		PLAC	847..877	CDD:462560	4/37 (11%)
adamtsl3	XP_003198947.5	None