DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and adamts10

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_004911053.2	Gene:	adamts10 / 100494667	XenbaseID:	XB-GENE-961723	Length:	1139	Species:	Xenopus tropicalis

Alignment Length:	746	Identity:	191/746 - (25%)
Similarity:	293/746 - (39%)	Gaps:	183/746 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 PPQEAT---SSTSKKA---KKKVYPY---PR-----WDKWSDWSSCSRSCGGGVKYQVRKCINRN 210
            |..|.|   ::|.:|.   |::..|:   |.     |..||.|..|||:|||||...||.|.:
Frog   549 PAAEGTICQTNTIEKGWCYKRECVPFGTRPEGVDGAWGSWSSWGECSRTCGGGVSSSVRHCDS-- 611

  Fly   211 LLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPY----VKDD 271
              ....:....|:|..|||:.||...|...|.|||..||:.:::..|.|..|.|:.|    ||
Frog   612 --PRPTIGGKYCLGERKRYRSCNIDDCPAGSQDFREVQCAEFDNVPFRGKYYSWKSYRGGGVK-- 672

  Fly   272 AECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAH 336
             .|.|||:..|...:.....:|||||.|       |...::  :||:|.||.|.....:......
Frog   673 -SCSLNCLAEGFNFYTERAAAVIDGTLC-------RQDSYD--ICVNGECKHVGCDRILGSDTKE 727

  Fly   337 SGSVSCG--GLLCRPVTGIFTRNPLPEHAYIHVTTLPVGASNISITELKNSINLLVLRTSNELAI 399
            .....||  |..|..:.|||.:: |||..|..|..:|.|:.:|.|.:|..|::.|.|:.......
Frog   728 DKCRVCGGDGSTCETIEGIFNQS-LPEGGYEEVVWIPKGSVHIDIRQLNISLSYLALKAKEGSEY 791

  Fly   400 F-NGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKY 463
            : ||.........::..|.:|.|.|.....:|      :.::||...:|.:||..:.....|::|
Frog   792 YINGRFPPDTPQRFDVAGTIFHYRRPQEEPES------LEALGPTNTTLIVMVAVREEILPGIRY 850

  Fly   464 EYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFNWKVIGFSSCTKSCGGGTQT 528
            ::..||      |:::..|                         :.|.:..::.|:..|.||.|.
Frog   851 KFNAPI------NQVTQNS-------------------------YAWYLSSWTKCSAICAGGVQL 884

  Fly   529 PIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSSGGLRRREVS 593
            ..:.|.:.:.....|...|..|.:  :.|....|||:|||..|....|.||..|.:.|:|.|.|.
Frog   885 QQVLCKKFSDGSTVSGDLCDPSSR--IQEKQRPCNTEPCPPEWAIGAWSECSRSCNSGVRTRSVI 947

  Fly   594 CVQELASGLVIHVDKAACMEDQPPMQKQCE---CPKNRRRNLSRYRLSGPSESSSNSSQVKRSKI 655
            |.:.::......:|.|:|.:.:|.|.:.|.   ||..
Frog   948 CQRRVSGTDKKSLDDASCPQPRPSMLEPCNTDTCPPE---------------------------- 984

  Fly   656 DGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRSKAGEQRCDPSTTPESRRPCEKPACELGDW 720
                    |:..||:: |:.:||.|..:|.|.|   |.|:|   .||.|
Frog   985 --------WVALDWSE-CTPSCGPGYRHRVVLC---KIGDQ---DSTLP---------------- 1018

  Fly   721 FTGPWSSCNGDCFDLTRTREVLCIRSQLITEHSECTPELKPQSVEKCSHEEVEYC-AARWHYSDW 784
                                           ||.|..:.||.:..:|:   ::.| .:||...:|
Frog  1019 -------------------------------HSHCQAKDKPATTMRCT---LQRCPPSRWITGEW 1049

  Fly   785 SECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCAD 849
            .||:..||.|.|||||:||.:     ..:.|..|..:.|....:.|..:..|:  .::....|.|
Frog  1050 GECSANCGLGQQRRSVQCLSH-----IGQPSIECTESFRPSAMQQCENKCLAD--PSDSPDECKD 1107

  Fly   850 --KFSNCQWASQAKLCSYDYYRDNCCFSCTG 878
              |.:.|....:.|.||..|:|..||.:|.|
Frog  1108 VNKVAYCPLVLKFKFCSRPYFRQMCCKTCQG 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	22/55 (40%)
		ADAM_spacer1	348..468	CDD:283607	30/120 (25%)
		TSP1	667..716	CDD:214559	15/48 (31%)
		TSP1	779..835	CDD:214559	18/55 (33%)
		PLAC	847..877	CDD:285849	11/31 (35%)
adamts10	XP_004911053.2	Pep_M12B_propep	74..217	CDD:396235
		ZnMc_ADAMTS_like	276..489	CDD:239801
		ADAM_CR_2	504..572	CDD:407643	6/22 (27%)
		TSP1	585..637	CDD:214559	22/55 (40%)
		ADAM_spacer1	741..855	CDD:368694	30/120 (25%)
		TSP1_ADAMTS	866..921	CDD:408800	14/56 (25%)
		TSP1_ADAMTS	925..981	CDD:408800	16/55 (29%)
		TSP1_ADAMTS	985..1039	CDD:408800	22/110 (20%)
		TSP1_ADAMTS	1044..1093	CDD:408800	18/53 (34%)
		PLAC	1105..1137	CDD:400844	11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000