Protein Alignment loh and adamts10

DIOPT Version :10

• Sequence 1: NP_609406.2
• Gene: loh / 34435
• FlyBaseID: FBgn0032252
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: XP_004911053.2
• Gene: adamts10 / 100494667
• XenbaseID: XB-GENE-961723
• Length: 1139
• Species: Xenopus tropicalis
• Alignment Length: 746
• Identity: 191/746 - (25%)
• Similarity: 293/746 - (39%)
• Gaps: 183/746 - (24%)

  Fly   160 PPQEAT---SSTSKKA---KKKVYPY---PR-----WDKWSDWSSCSRSCGGGVKYQVRKCINRN 210
            |..|.|   ::|.:|.   |::..|:   |.     |..||.|..|||:|||||...||.|.:
 Frog   549 PAAEGTICQTNTIEKGWCYKRECVPFGTRPEGVDGAWGSWSSWGECSRTCGGGVSSSVRHCDS-- 611

  Fly   211 LLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPY----VKDD 271
              ....:....|:|..|||:.||...|...|.|||..||:.:::..|.|..|.|:.|    ||
 Frog   612 --PRPTIGGKYCLGERKRYRSCNIDDCPAGSQDFREVQCAEFDNVPFRGKYYSWKSYRGGGVK-- 672

  Fly   272 AECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAH 336
             .|.|||:..|...:.....:|||||.|       |...::  :||:|.||.|.....:......
 Frog   673 -SCSLNCLAEGFNFYTERAAAVIDGTLC-------RQDSYD--ICVNGECKHVGCDRILGSDTKE 727

  Fly   337 SGSVSCG--GLLCRPVTGIFTRNPLPEHAYIHVTTLPVGASNISITELKNSINLLVLRTSNELAI 399
            .....||  |..|..:.|||.:: |||..|..|..:|.|:.:|.|.:|..|::.|.|:.......
 Frog   728 DKCRVCGGDGSTCETIEGIFNQS-LPEGGYEEVVWIPKGSVHIDIRQLNISLSYLALKAKEGSEY 791

  Fly   400 F-NGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKY 463
            : ||.........::..|.:|.|.|.....:|      :.::||...:|.:||..:.....|::|
 Frog   792 YINGRFPPDTPQRFDVAGTIFHYRRPQEEPES------LEALGPTNTTLIVMVAVREEILPGIRY 850

  Fly   464 EYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFNWKVIGFSSCTKSCGGGTQT 528
            ::..||      |:::..|                         :.|.:..::.|:..|.||.|.
 Frog   851 KFNAPI------NQVTQNS-------------------------YAWYLSSWTKCSAICAGGVQL 884

  Fly   529 PIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSSGGLRRREVS 593
            ..:.|.:.:.....|...|..|.:  :.|....|||:|||..|....|.||..|.:.|:|.|.|.
 Frog   885 QQVLCKKFSDGSTVSGDLCDPSSR--IQEKQRPCNTEPCPPEWAIGAWSECSRSCNSGVRTRSVI 947

  Fly   594 CVQELASGLVIHVDKAACMEDQPPMQKQCE---CPKNRRRNLSRYRLSGPSESSSNSSQVKRSKI 655
            |.:.::......:|.|:|.:.:|.|.:.|.   ||..
 Frog   948 CQRRVSGTDKKSLDDASCPQPRPSMLEPCNTDTCPPE---------------------------- 984

  Fly   656 DGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRSKAGEQRCDPSTTPESRRPCEKPACELGDW 720
                    |:..||:: |:.:||.|..:|.|.|   |.|:|   .||.|
 Frog   985 --------WVALDWSE-CTPSCGPGYRHRVVLC---KIGDQ---DSTLP---------------- 1018

  Fly   721 FTGPWSSCNGDCFDLTRTREVLCIRSQLITEHSECTPELKPQSVEKCSHEEVEYC-AARWHYSDW 784
                                           ||.|..:.||.:..:|:   ::.| .:||...:|
 Frog  1019 -------------------------------HSHCQAKDKPATTMRCT---LQRCPPSRWITGEW 1049

  Fly   785 SECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCAD 849
            .||:..||.|.|||||:||.:     ..:.|..|..:.|....:.|..:..|:  .::....|.|
 Frog  1050 GECSANCGLGQQRRSVQCLSH-----IGQPSIECTESFRPSAMQQCENKCLAD--PSDSPDECKD 1107

  Fly   850 --KFSNCQWASQAKLCSYDYYRDNCCFSCTG 878
              |.:.|....:.|.||..|:|..||.:|.|
 Frog  1108 VNKVAYCPLVLKFKFCSRPYFRQMCCKTCQG 1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	22/55 (40%)
		ADAMTS_spacer1	349..468	CDD:461796	30/119 (25%)
		TSP1_ADAMTS	510..567	CDD:465950	14/56 (25%)
		TSP1_ADAMTS	664..715	CDD:465950	16/50 (32%)
		TSP1_ADAMTS	720..768	CDD:465950	5/47 (11%)
		TSP1_ADAMTS	779..835	CDD:465950	18/55 (33%)
		PLAC	847..877	CDD:462560	11/31 (35%)
adamts10	XP_004911053.2	Pep_M12B_propep	97..217	CDD:460254
		ZnMc_ADAMTS_like	276..489	CDD:239801
		ADAMTS_CR_2	504..572	CDD:465496	6/22 (27%)
		TSP1	585..637	CDD:214559	22/55 (40%)
		ADAMTS_CR_3	642..740	CDD:437068	33/109 (30%)
		ADAMTS_spacer1	742..855	CDD:461796	30/119 (25%)
		TSP1_ADAMTS	866..921	CDD:465950	14/56 (25%)
		TSP1_ADAMTS	925..981	CDD:465950	16/55 (29%)
		TSP1_ADAMTS	985..1039	CDD:465950	22/110 (20%)
		TSP1_ADAMTS	1044..1093	CDD:465950	18/53 (34%)
		PLAC	1105..1137	CDD:462560	11/31 (35%)