DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and thsd4

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_017947904.2	Gene:	thsd4 / 100493458	XenbaseID:	XB-GENE-6035027	Length:	988	Species:	Xenopus tropicalis

Alignment Length:	982	Identity:	238/982 - (24%)
Similarity:	353/982 - (35%)	Gaps:	308/982 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 PQEATSSTSKKAKKKVYPYPRWDKWSDWSSCSRSCGGGVKYQVRKCI------------------ 207
            ||.....:.........|...|..|..||:|||||.|||..|.|.|:
Frog    35 PQRIEKQSDTAENITTVPSGTWGTWGPWSACSRSCSGGVMEQTRPCLPAHYQQRSFQAPSQQYST 99

  Fly   208 --------------------------------------------------------NRNLL---- 212
                                                                    ||.:|
Frog   100 GERTHSNQNNLHHDTVINPYAGHVVSAIRTSIPLHRRGENPQFNIQSSGDLSQNHHNRGILRGGR 164

  Fly   213 ----------------------------------------------------------------- 212

Frog   165 QPLIPGHIPRHEKRNRTRGLISPGSYGYGKVPYGLPLQRDTGQEARRTRRQRQSVRQSTYKQSTD 229

  Fly   213 --------TNNQL--------------------------------TSNACVGYFKRYQLCNDVPC 237
                    |.:|:                                |:..|:|.:|:|:|||...|
Frog   230 ALVNQRQATYSQVSSVPQGLYPDISRHGLASLQLLQEKPQVPRGATAITCIGPYKQYKLCNKNLC 294

  Fly   238 DEQSPDFRASQCSAYNDKEFHGHRYRWEPYVKDDA--ECELNCMPFGMKSFATLNESVIDGTPCG 300
            ...:...|..||::||:|.|.|..|.|||:.::..  :|||.|...|.:.:....|.||||.||.
Frog   295 PGSNRGIREVQCASYNNKPFMGRLYEWEPFTEEKGALKCELTCRAVGYRFYVRQAEKVIDGAPCD 359

  Fly   301 HPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSV-----SCGG--LLCRPVTGIFTRNP 358
            ...         .||||.|.||.:....     |..|..|     .|||  ..|:.|:|:| ::.
Frog   360 DNG---------TAVCVSGQCKNIGCDD-----YLGSDKVLDKCGVCGGDNTACKVVSGVF-KHV 409

  Fly   359 LPEHAYIHVTTLPVGASNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHR 423
            |.:..|..|..:|.||:.|::||:..|.|.|.||:.:..:|.||...:...|.||..|.:|.|.|
Frog   410 LIKVGYHKVVEIPEGATKINVTEMTKSNNYLALRSRSGRSIINGNWAIDRPGRYEGGGTMFTYKR 474

  Fly   424 IDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMS--------- 479
            .:  |.|:...|...:.||..:.|.:.:..:.. |.|:.|||::|     .||.:|
Frog   475 PN--EISSTAGESFLAEGPTNEVLDVYMIHQQP-NPGIHYEYVIP-----AENAISPQLPPHRRP 531

  Fly   480 LESSDGLLRSGME-----------DTSSSSSSRAG------------------RKRIFNWKVIGF 515
            :|..:|.|....:           ||.|......|                  |.|.||||.:|.
Frog   532 VEPFNGQLEETSDPTENGDSFSEIDTESFPGRHPGRYPSHQPDNQVLPLQPPRRSRDFNWKQVGS 596

  Fly   516 SSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECR 580
            :.|:.:||.|::.|:.||:.:|.....:...|..|.||...|.  .||..||||:|...:|.||.
Frog   597 TECSTTCGKGSRYPVFRCVNRNTHEETADGFCDASAKPSAEEE--PCNLFPCPAFWDIGEWSECS 659

  Fly   581 CSSSGGLRRREVSCVQELAS-GLVIHVDKAACME--------------------DQPPMQKQCEC 624
            .:...|::.|::.|....|: .|.:...:...:|                    |..|....|..
Frog   660 KTCGLGMQHRQILCRHSYANRTLTVQPHRCQSLEKPETTSTCQLKICSEWQIRTDWTPCSVPCGV 724

  Fly   625 PKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSD---ATAIWLVSDWNQYCSVTCGSGVEYRTV 686
            .:..|.......:....:....:.:::...|:..|   ....|.:::|:..||..||.||..|:|
Frog   725 GQKTRDVKCISNIGDIVDDEECNMKLRPDDIENCDMGPCAKSWFLTEWSDRCSAECGEGVRTRSV 789

  Fly   687 FCDRSK--------AGEQRCDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLC 743
            .|..:.        .|..| .|.||..:..|||...    :||.|.||.|:.:|...|:.|:|:|
Frog   790 VCMSNHISSLPLEGCGNHR-PPETTTCNNGPCEGKV----EWFMGSWSQCSVECGTGTQQRDVIC 849

  Fly   744 IRSQL----ITEHSECTPELKPQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRCLE 804
            |:...    :...:||:...:|.:.:.|   .::.|.|:|.|:|||.|:|.|.||.:.|.||||.
Frog   850 IKKTAEGFNVVNPNECSYLERPPNQQSC---HLKSCGAKWFYTDWSTCSKSCEGGFRIREVRCLA 911

  Fly   805 YDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFSNCQWASQAKLCSYDYYR 869
            .|     :..|..|....:.....:||.|.|  :|  |:...|.||:.||....||:||.|.||:
Frog   912 DD-----MSHSDKCDQELKPEDTESCNTQDC--MP--EIDENCKDKYYNCNVVVQARLCVYAYYK 967

  Fly   870 DNCCFSC 876
            ..||.||
Frog   968 TACCASC 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	28/238 (12%)
		ADAM_spacer1	348..468	CDD:283607	38/119 (32%)
		TSP1	667..716	CDD:214559	18/56 (32%)
		TSP1	779..835	CDD:214559	21/55 (38%)
		PLAC	847..877	CDD:285849	16/30 (53%)
thsd4	XP_017947904.2	TSP1	56..>80	CDD:214559	14/23 (61%)
		ADAM_spacer1	400..516	CDD:368694	38/119 (32%)
		TSP1_ADAMTS	597..646	CDD:408800	15/50 (30%)
		TSP1_ADAMTS	650..706	CDD:408800	10/55 (18%)
		TSP1_ADAMTS	709..763	CDD:408800	6/53 (11%)
		TSP1_ADAMTS	767..820	CDD:408800	16/53 (30%)
		TSP1_ADAMTS	826..882	CDD:408800	16/58 (28%)
		TSP1_ADAMTS	886..937	CDD:408800	21/55 (38%)
		PLAC	945..974	CDD:400844	14/28 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2147
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201044at33208
OrthoFinder	1	1.000	-	-		FOG0005105
OrthoInspector	1	1.000	-	-		otm48219
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.970