DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and adamts15

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_012822382.1	Gene:	adamts15 / 100489270	XenbaseID:	XB-GENE-6051208	Length:	938	Species:	Xenopus tropicalis

Alignment Length:	642	Identity:	150/642 - (23%)
Similarity:	231/642 - (35%)	Gaps:	172/642 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 KKKISINSYYELANLWHTRKDLSSPKQKPNNKEEYLENETTSKISNKSDEKVLKSSTIISLNATN 113
            |:..|:.....|.:.:.|..:|......|::..:..| |...|:.    |..:.|.|:|.::..|
Frog   343 KRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCE-EAFGKLR----ENYMMSPTLIQIDRAN 402

  Fly   114 PSTSTFKSVLETTTLPSVTTKDLFESGNVATTRQTPKVEEVFSSPNPPQEATSSTSKKAK----- 173
            |.::...:::          .|..:||:.......|  .:..|.|.....|..|.|::.:
Frog   403 PWSACSAAII----------TDFLDSGHGECLLDEP--AKPISLPEELPGARYSLSRQCELAFGL 455

  Fly   174 -KKVYPYPR-------------------------------------------------------W 182
             .|..||.:                                                       |
Frog   456 GSKPCPYMQYCTKLWCTGRARGQLVCQTRHFPWADGTSCGDGKFCLNGACVERHNVNRYKVDGAW 520

  Fly   183 DKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNA---CVGYFKRYQLCNDVPCDEQSPDF 244
            .|||.:..|||:|||||:...|:|       ||...||.   |.|...:|:.|:..||.|....|
Frog   521 GKWSPYGQCSRTCGGGVQLAKREC-------NNPEPSNGGSFCEGLRVKYRSCSLNPCPETGKSF 578

  Fly   245 RASQCSAYNDKEFHGHRYR----WEPY---VKDDAECELNCMPFGMKSFATLNESVIDGTPCGHP 302
            |..||.::|......:|..    |.|.   |....:|:|.|...|...|..|:..|:|||||...
Frog   579 REEQCESFNGFNHSTNRITQTVGWVPKYSGVSPRDKCKLICRANGTGYFYVLSPKVVDGTPCSPD 643

  Fly   303 AEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCGG--LLCRPVTGIFTRNPLPEHAYI 365
            |         .:|||.|.|......|::.....:.....|||  ..|:.::|:||:   |.|.|.
Frog   644 A---------TSVCVQGKCIKAGCDGQLGSKKKYDKCRVCGGDNKSCKKISGLFTK---PIHGYN 696

  Fly   366 HVTTLPVGASNISITE-----LKNSINLLVLRTSNELAIFN-------GENTVSESGS---YEAV 415
            .|.|:|.||||:.:.:     |.|..|.|.::.:....:.|       ||..:|..||   |...
Frog   697 FVVTIPAGASNLDVRQRGYKGLINDDNYLAVKNAQGRYLLNGNYIVAAGERDISVRGSLLKYSGT 761

  Fly   416 GAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVF-TKSANNTGVKYEYMLPIVSESEENEMS 479
            |.               ..|.:.:|..|::||.:.|. ........::|.:.:|
Frog   762 GT---------------AVETLQAINVIQESLTIEVLCVGKMTPPRLRYSFYIP----------- 800

  Fly   480 LESSDGLLRSGMEDTSSSSSSRAG-------RKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKN 537
            .|..||.:...:      |:|.||       .|...||....:..|:.|||.|.|...|.|  ::
Frog   801 REKKDGKVGQVI------SNSLAGLPPPLPRLKPQSNWIAGNWGDCSVSCGTGHQIRTIEC--RD 857

  Fly   538 PLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSSGGLRRREVSC 594
            |....:. .|..:::|.....   |. .|||. |...:|..|..|...|.:||::.|
Frog   858 PWEQLAS-DCQAALRPSERRT---CG-DPCPV-WDAGEWSSCSKSCGRGFKRRQLRC 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	23/58 (40%)
		ADAM_spacer1	348..468	CDD:283607	32/135 (24%)
		TSP1	667..716	CDD:214559
		TSP1	779..835	CDD:214559
		PLAC	847..877	CDD:285849
adamts15	XP_012822382.1	Pep_M12B_propep	30..158	CDD:366707
		ZnMc_ADAMTS_like	219..425	CDD:239801	18/96 (19%)
		ADAM_CR_2	439..506	CDD:375321	6/66 (9%)
		TSP1	520..572	CDD:214559	23/58 (40%)
		ADAM_spacer1	682..800	CDD:368694	32/135 (24%)
		TSP1	835..883	CDD:214559	13/54 (24%)
		TSP1	884..938	CDD:214559	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910