DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and adamtsl4

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_002935503.2	Gene:	adamtsl4 / 100488255	XenbaseID:	XB-GENE-986796	Length:	1427	Species:	Xenopus tropicalis

Alignment Length:	984	Identity:	256/984 - (26%)
Similarity:	407/984 - (41%)	Gaps:	210/984 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DSSFVQADLTTKER----IKKHQDWLREHR-------KP-----KTKKKISINSYYELANLWHTR 67
            |:|..|:|:..:..    ::..:|..|..|       ||     .|||..:..|..|.:.|.:.|
Frog   523 DNSKTQSDVYNRNGDQPFMENRKDIRRISRAKMFGTVKPMQRLDATKKGQNERSPLEGSVLLNER 587

  Fly    68 -KDLSSPKQKPNNKEEYLENETTSKISNKSDEKVLKSSTIISLNATNPSTSTFKSVLETTTLPSV 131
             ..|:|..:|.....:..::|.|:..:::...:|...|.::..:         :|..::.....|
Frog   588 ASHLNSHVKKITKHSDGSDSEITADEADQHHHQVASDSVLLPRS---------RSQRQSQNRHGV 643

  Fly   132 TTKDLFESGNVATTRQTPKVEE-VFSSPNP------------PQEATSSTSKKAKKKVYPYPRWD 183
            ....:|::    ..|:.|.|.. ..|.|.|            .|:..||..:.::     .|:|:
Frog   644 DNSRVFQN----LFREHPSVHRPAQSDPWPAFGRSPTVAHEREQDVGSSLHQNSE-----LPQWN 699

  Fly   184 KWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQ 248
                                        |.|.......|.|..|:|:.||...|....||.||..
Frog   700 ----------------------------LYNPASEEFHCEGEQKQYKSCNQEACPSGQPDARAKH 736

  Fly   249 CSAYNDKEFHGHRYRWEPY--VKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFW 311
            |:.:|.:||.|..|:||.:  |..:..|.|||.|.|.:.:....|.|.|||||         :..
Frog   737 CATFNSQEFMGRLYQWEAFTEVSGNQRCALNCRPIGYRFYVRHTEKVQDGTPC---------EAG 792

  Fly   312 ERAVCVDGACKAVQASGEIDGLYAHSGSV-SCG-----GLLCRPVTGIFTRNPLPEHAYIHVTTL 370
            ...|||||.|    .|...||:...:.:: :||     |..|:.:||.|....:| ..|..:..:
Frog   793 SLDVCVDGQC----LSPGCDGILGSNSTLDTCGVCGGDGSTCKFITGTFKETNVP-IGYHKILEI 852

  Fly   371 PVGASNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTE 435
            |.||:.|.:.||..|.|.|.||:....:..||...|..:|.|||.|.||.|.: .|.|:..|  |
Frog   853 PKGATQIKVRELTWSPNYLALRSRTGKSFINGNWAVDPAGRYEAGGTVFIYTQ-PGREEQEG--E 914

  Fly   436 WITSIGPIRDSLQL-MVFTKSANNTGVKYEYML--PIVSESEENEMSLESSD-GLLRS-GMEDTS 495
            ..|:.||..::|.: |:|.:  :|.|:.:::.:  |..:::..::.:....: |.||| ...:|.
Frog   915 TFTAAGPTSEALDVYMIFQQ--DNPGISFQFFISSPTAADASGHQSNPSQQEYGALRSMSASETL 977

  Fly   496 SSSSSRA-------------GRKR--------------------------IFNWKVIGFSSCTKS 521
            :::.||.             .|:|                          .|.||.:|.::|:.|
Frog   978 ANTGSRTQPPDDRPLVPPPQSRQRPVSTLQRNIRVPPLQSPPVHYWPEQPQFFWKRVGSTACSVS 1042

  Fly   522 CGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSSGG 586
            ||.|...|:.:|:.:|.|...|:..|..|.||...|..  ||||||||:|...:|..|..:...|
Frog  1043 CGKGFWYPVYQCVSRNSLEEVSEEECDLSNKPFPQEEA--CNTQPCPAFWDVGNWSVCSRTCGNG 1105

  Fly   587 LRRREVSCVQELAS-GLVIHVDKAACMEDQPPMQKQCE--------------------------- 623
            ::.|:|.|.|..|: ..::|..:.:.:. :|.:.:.|:
Frog  1106 IQHRQVLCRQMYANRTTMVHPQRCSHLV-KPNVTQTCQLRICSHWEIQSNWSTCSVMCGLGQRTR 1169

  Fly   624 ---CPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYRT 685
               |..|:...:      |..|.|:..........|.......|..::|:..||..||:|::.|:
Frog  1170 HVRCVSNQGDEV------GDGECSNRLRPRTNEACDMGPCVRSWFHNEWSPICSTECGTGIQRRS 1228

  Fly   686 VFCDRSK---AGEQRCDPSTTPESRRPCEKPACE-LGDWFTGPWSSCNGDCFDLTRTREVLCIRS 746
            |||..|.   ..::.|..| .|...|.|....|| ...|:||||:.|:.||.|.::.|:|:|: |
Frog  1229 VFCLSSSPTDESQESCGGS-KPSDMRVCNSGPCERTVKWYTGPWTQCSADCGDGSQKRDVICV-S 1291

  Fly   747 QL-----ITEHSECTPELKPQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRCLEYD 806
            :|     :|:.|||:...||..::.|:   ...|...|..:.||.|::.|.||.|.|.||||..|
Frog  1292 KLGAEFNVTDPSECSHLEKPLPLQSCN---AGPCGPSWFTTPWSACSQSCLGGLQMREVRCLASD 1353

  Fly   807 IKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFSNCQWASQAKLCSYDYYRDN 871
            ...     |..|....:....|.||.|.|:    ..:...|.|::.||....||:||.|.||:..
Frog  1354 KSF-----SQQCDQDTKPEDKRVCNTQPCS----AALDENCRDRYHNCAVVVQARLCVYGYYKQA 1409

  Fly   872 CCFSCTGGI 880
            ||.||...:
Frog  1410 CCSSCAHAV 1418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	9/55 (16%)
		ADAM_spacer1	348..468	CDD:283607	39/122 (32%)
		TSP1	667..716	CDD:214559	16/51 (31%)
		TSP1	779..835	CDD:214559	20/55 (36%)
		PLAC	847..877	CDD:285849	14/29 (48%)
adamtsl4	XP_002935503.2	TSP1	45..>77	CDD:214559
		ADAM_spacer1	831..945	CDD:368694	39/119 (33%)
		TSP1_ADAMTS	1037..1086	CDD:408800	19/50 (38%)
		TSP1_ADAMTS	1090..1146	CDD:408800	12/56 (21%)
		TSP1_ADAMTS	1149..1203	CDD:408800	6/59 (10%)
		TSP1_ADAMTS	1207..1260	CDD:408800	17/53 (32%)
		TSP1_ADAMTS	1266..1322	CDD:408800	21/59 (36%)
		TSP1_ADAMTS	1326..1377	CDD:408800	20/55 (36%)
		PLAC	1385..1414	CDD:400844	13/28 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2147
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201044at33208
OrthoFinder	1	1.000	-	-		FOG0005105
OrthoInspector	1	1.000	-	-		otm48219
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.970