DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and adamtsl4

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_021322467.1	Gene:	adamtsl4 / 100333903	ZFINID:	ZDB-GENE-070815-2	Length:	1089	Species:	Danio rerio

Alignment Length:	971	Identity:	255/971 - (26%)
Similarity:	382/971 - (39%)	Gaps:	219/971 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 HRKPKTKKKISINSYYELANLWHTRKDLSSPKQKPNNKEEYLENETTSKISNKSDEKVLKSSTII 107
            :|.|.:.::.|  |........:.|...|.|..:.|....:..:.|::.
Zfish   193 NRDPASVRRSS--SSIRPGQFGYGRVPFSLPLHRQNRHARHTHHNTSTD---------------- 239

  Fly   108 SLNATNPSTSTF-KSVLETTTLPSVT-------------------------TKDLFESGNVATTR 146
            ||:|.|.::|:. :...|.|....|:                         .:|....|.  |:|
Zfish   240 SLDALNVNSSSHGEKTHEKTPADKVSEDNDDGEQRRRVRIPHIRPPAQRNGARDRRIEGR--TSR 302

  Fly   147 QTP-----KVEEVFSSPNPPQEATSSTSKKAKKKVYPYPRWDKWS---------DWSSCSRSCGG 197
            |.|     .:....:|.:||.....:.|.         |..:.|:         ||
Zfish   303 QAPPSYTRTISRTHTSRDPPPYGPQTPSN---------PNPEPWAPVQTPGNEQDW--------- 349

  Fly   198 GVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRY 262
                       |..:..|.    .|.|..:.|:.|:...|...:.:.||.||||:|.:||.|..|
Zfish   350 -----------RPPVAGNY----RCSGRDREYRRCSLQACPGAAVNSRADQCSAFNAQEFMGRVY 399

  Fly   263 RWEPY--VKDDAECELNCMPFGMKSFATLNESVIDGTPCGH--PAEYFRSQFWERAVCVDGACKA 323
            .|||:  |..:.:|||.|.|.|.:.:....|.|.|||||.:  |.:          |||.|.|.:
Zfish   400 DWEPFTEVGLEQQCELTCRPVGYRFYVRQAERVRDGTPCANNTPTD----------VCVGGRCLS 454

  Fly   324 VQASGEI-DGLYAHSGSVSCGGL--LCRPVTGIFTRNPLPEHAYIHVTTLPVGASNISITELKNS 385
            ....|.: .||......| |||.  .|..|:|.|....:| ..|..:..:|.||:.|:|||.:.|
Zfish   455 EGCDGVLGSGLVRDRCGV-CGGEDGTCERVSGSFMNTSVP-LGYHKILDIPPGATAINITERRAS 517

  Fly   386 INLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHR--IDGAEDSNGVTEWITSIGPIRDSLQ 448
            .|.|.||:....::.||...|...|.|:|.||.|.|.|  .:..|......|.:|:.||....||
Zfish   518 PNYLALRSGTGQSVVNGRWAVDPPGEYQAGGAAFLYTRPKAEPQEPGEDRGETLTAAGPTTALLQ 582

  Fly   449 L-MVFTKSANNTGVKYEYMLP----------IVSESEENEMSLESSDGL------------LRSG 490
            | ::|.:  .|.|:.|||.:|          ::.|.|....:|..:.|:            :.|.
Zfish   583 LYIIFHR--QNPGIDYEYYIPVDKRRDGEREVLRERERGRSALRETTGVSMAVENPVAPPPVSSS 645

  Fly   491 MEDTSSSSSSRAGR---KR--------------------------IFNWKVIGFSSCTKSCGGGT 526
            ...:||||||.:.|   :|                          :|.|:....:.||.:||.|:
Zfish   646 FPSSSSSSSSSSDRWPPERPRPQGLGPNRNARIPPRTDLPLDNLPVFVWRRGALTECTATCGKGS 710

  Fly   527 QTPIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSSGGLRRRE 591
            |...|.|:.::..:...:|||..:.||...|.  .||..|||.:|....|.||..|...|:::|:
Zfish   711 QYREIVCVNRHTEQEVHERRCDSATKPTPEEE--PCNVHPCPPFWDMGAWSECSVSCGWGVQQRQ 773

  Fly   592 VSCVQELAS-GLVIHVDKAACME----DQPPMQKQC--------------ECPKNRR-RNLSRYR 636
            :.|.|...: ..::|..:.|.:.    .||...:.|              :|...:| ||:....
Zfish   774 IQCRQSFGNRSTMVHPQRCAGLSRPNATQPCHPRVCSHWEISTNWSTCSVDCGMGKRTRNVRCVS 838

  Fly   637 LSGPSESSSNSSQVKRSKIDGSD-----ATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRSKAGEQ 696
            ..|.:.:....:...|.: ...|     ....|..:||...||..||.||:.|.|.| .|..|.:
Zfish   839 NHGNTVNDRECNDRLRPQ-HSEDCHMGPCVTNWYFTDWTHTCSAECGPGVQRREVVC-VSAGGRR 901

  Fly   697 RCDPSTTPESRRPCEKPACELGD------WFTGPWSSCNGDCFDLTRTREVLCIRSQ----LITE 751
            ..|........:|.:..||..|.      |:||||..||..|.:.|:.|:|:|:|..    .::.
Zfish   902 EGDGGLECVGDKPADMKACNGGPCTATYLWYTGPWGYCNAVCGNGTQRRDVICVRKSGSEFTVSS 966

  Fly   752 HSECTPELKPQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNALREST 816
            .|:|:...||..|:.|   |::.|..:|..:|||.|::.||.|.|.|.||||..|     .:.|.
Zfish   967 SSDCSHLEKPSPVQPC---ELQPCTPQWFTTDWSTCSRSCGEGLQTREVRCLTPD-----KQHSA 1023

  Fly   817 HCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFSNCQWASQAKLCSYDYYRDNCCFSCT 877
            .|....|....:.||...|:......    |.|:..||....||:||.|.||:..||.|||
Zfish  1024 TCHPDARPAHQQPCNTIPCSPFEDEN----CKDRRHNCVMVVQARLCVYSYYKTACCASCT 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	9/64 (14%)
		ADAM_spacer1	348..468	CDD:283607	42/122 (34%)
		TSP1	667..716	CDD:214559	16/48 (33%)
		TSP1	779..835	CDD:214559	20/55 (36%)
		PLAC	847..877	CDD:285849	14/29 (48%)
adamtsl4	XP_021322467.1	TSP1	49..>81	CDD:214559
		ADAM_spacer1	481..601	CDD:310520	42/122 (34%)
		TSP1	700..750	CDD:214559	17/51 (33%)
		TSP1	753..810	CDD:214559	13/56 (23%)
		TSP1	809..866	CDD:214559	8/57 (14%)
		TSP1	872..925	CDD:214559	18/53 (34%)
		TSP1	991..1043	CDD:214559	20/56 (36%)
		PLAC	1050..1080	CDD:312271	14/29 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2324
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201044at33208
OrthoFinder	1	1.000	-	-		FOG0005105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106612
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.870