DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loh and adamts12

DIOPT Version :9

Sequence 1:NP_609406.2 Gene:loh / 34435 FlyBaseID:FBgn0032252 Length:880 Species:Drosophila melanogaster
Sequence 2:XP_021332071.1 Gene:adamts12 / 100003937 ZFINID:ZDB-GENE-070705-471 Length:1500 Species:Danio rerio


Alignment Length:987 Identity:231/987 - (23%)
Similarity:335/987 - (33%) Gaps:338/987 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQ----LTSNACVGYFKRYQLCNDVPCDEQSP 242
            |..||.||.|||:||.||:...|:|        ||    .....|.|..|||::||...|..:.|
Zfish   558 WGPWSSWSHCSRTCGAGVQTADREC--------NQPKPEFGGKYCTGERKRYRVCNTKLCVRKHP 614

  Fly   243 DFRASQCSAYNDKEFHGHRYRWEPYVKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFR 307
            .||..|||.:|...:|...|:|.|.......|||:|.|........:.::|.|||||     :..
Zfish   615 SFREMQCSEFNTVPYHNELYQWIPVSSPSRPCELHCKPVDENFSEKMLDAVTDGTPC-----FMN 674

  Fly   308 SQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTRNPLPEHAYIHV 367
            :.  .|.:||:|.||.|   |...|:.:::...|||     |..|..|...|...  ....|:.:
Zfish   675 NN--SRNICVNGVCKEV---GCDFGINSNAKEDSCGVCLGDGSTCETVKENFVEQ--DGFGYMDL 732

  Fly   368 TTLPVGASNISITELKNSINLLVLRTSNELAIF-NGENTVSESGSYEAVGAVFDYHRIDGAEDSN 431
            ..:|.||.:|.|.|::.:.|.|.:|.|:....: ||...:..:|.|||.|..|:|.|       :
Zfish   733 VLIPAGARDIYIQEVEEAGNFLAMRASDSDEYYLNGNYIIQWNGEYEAGGTKFNYER-------S 790

  Fly   432 GVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYML----PIVSESEENE--------------- 477
            |..|.:||.||..:.:.:.:..:.. |.||||||.:    |:.:|..|.|               
Zfish   791 GNIENLTSAGPTTEPVMIQLLFQEL-NPGVKYEYTIKRRRPLGNEILEPEYIWKHGAWTDCSTTC 854

  Fly   478 ---------MSLESSDGLLRSGMEDTSSSSSSR----AGRKRIFNWKVIGFSSCTKSCGG-GTQT 528
                     ...|...|::...:.|.|:....:    ..|.....|.|.|:.:|:.:||. |.:.
Zfish   855 GLGEQHQPVRCFEPEVGVVEENLCDPSTRPDDKHRKCKSRDCPARWWVGGWQTCSSTCGSTGVKK 919

  Fly   529 PIIRCIR--KNPLRYYSQRRCTHSVKPVLNENLLHCNTQ-PCPAYWRFDDWGECRCSSSGGLRRR 590
            ..|.|:|  ....|......|...:||   :..:.||.. ||.:.|...:|.||..|..||::.|
Zfish   920 RTILCVRTVAGEERVLHPGDCKQLLKP---KPAVPCNRDVPCGSEWTVGNWSECSQSCDGGIKSR 981

  Fly   591 EVSCVQELASGL----------------------------------------------------- 602
            .|.||.:..|..                                                     
Zfish   982 MVKCVAKQPSRCNPATRPRSTILCNLQSCSSTNRWTGPRFRPRKIPTQPPGTQTTQYSPTITPPN 1046

  Fly   603 ----------------VIHVDK-------------AACMED-------QPPMQK------QCECP 625
                            :||.|.             ....||       |||.:.      ..|.|
Zfish  1047 TSTPITTQSNTSPTSDIIHEDDKDFILVKKNNVAVPTITEDEEGSTDLQPPDKSYTPGYDYIEDP 1111

  Fly   626 KNRRRN--------------------------------------------------LSRYRLSG- 639
            :..|.:                                                  .|.|..:. 
Zfish  1112 ERIREDDLFTSKPEEVLISSVQPITMSAPVSTTKPAITTTIRTQYDGHLATHACAKTSLYEFNST 1176

  Fly   640 --PSESSSN--SSQV--------------------------KRSKI---------DGS------D 659
              |:.|..|  ||||                          .|.|:         ||:      .
Zfish  1177 PKPTLSHLNTLSSQVTVPTVKILRKALQTLKVPNKSNVLKAARLKLQMTTITDDDDGNLNAQIVS 1241

  Fly   660 ATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRSKAGEQRCDPSTTPESRRPCEKPACELGDWFTGP 724
            ..|.|.|.:|:. ||.:||.|..:|:|.|  |...|:.|.....||..|.|....|.:  |.||.
Zfish  1242 KNAFWKVGNWSD-CSTSCGLGAVWRSVSC--SSKQEEDCASVKKPEPARRCNLRPCAV--WKTGN 1301

  Fly   725 WSSCNGDCFDLTRTREVLCIRSQ------------------------------------------ 747
            ||.|...|....:.|||.||.:|                                          
Zfish  1302 WSKCPEGCVTDMKYREVQCIDTQNRRPLRPFHCQALSHKPPSSLPCNTLPCLQWMHSPWGECSKS 1366

  Fly   748 ----------LITEHSECTPELKPQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRC 802
                      ...|:..|...|||.|.|.|   .::.||. |....||:|::.||||.|:|:|||
Zfish  1367 CGHGVKERLVYCPENQHCNVTLKPNSTESC---HLQPCAG-WATEAWSQCSRSCGGGVQKRAVRC 1427

  Fly   803 LEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFSNCQWASQAKL---CS 864
            :..:  .....:::.|...|:....:||:.:.|    ||::..:|.....:..:..:.||   ||
Zfish  1428 INEE--SGEEEKASMCAIINKPDSVQNCSTEDC----KTDLGLLCKKNSMSSLFCEKLKLLGRCS 1486

  Fly   865 YDYYRDNCCFSC 876
            ....|..||.:|
Zfish  1487 LRSIRKQCCVTC 1498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lohNP_609406.2 TSP1 182..238 CDD:214559 23/59 (39%)
ADAM_spacer1 348..468 CDD:283607 36/124 (29%)
TSP1 667..716 CDD:214559 16/48 (33%)
TSP1 779..835 CDD:214559 17/55 (31%)
PLAC 847..877 CDD:285849 9/33 (27%)
adamts12XP_021332071.1 Pep_M12B_propep 51..190 CDD:307618
ZnMc_ADAMTS_like 259..466 CDD:239801
ADAM_CR 529..689 CDD:326582 52/145 (36%)
TSP1 558..609 CDD:214559 23/58 (40%)
ADAM_spacer1 715..825 CDD:310520 36/119 (30%)
TSP1 960..1011 CDD:214559 12/50 (24%)
TSP_1 1358..1401 CDD:326556 8/45 (18%)
TSP1 1404..1458 CDD:214559 17/55 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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