DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nse4 and Eid3

DIOPT Version :9

Sequence 1:	NP_001162938.1	Gene:	Nse4 / 34434	FlyBaseID:	FBgn0032251	Length:	290	Species:	Drosophila melanogaster
Sequence 2:	NP_079775.2	Gene:	Eid3 / 66341	MGIID:	1913591	Length:	375	Species:	Mus musculus

Alignment Length:	325	Identity:	65/325 - (20%)
Similarity:	124/325 - (38%)	Gaps:	78/325 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MDDQDARILRLQNLIEKNIEIEQQIENNTIGESITAIEEIIQTANDISKGHEDRRTNSTE---LV 71
            :|.:..|.:|.|  ..:.|...||...:.:..:...:.|.::.||.:..|....|..:.:   ||
Mouse    75 VDREKCRKIRRQ--YRQLIYTVQQNREDIVNTASDTLSEALEEANVLFDGVSRTREAALDAQFLV 137

  Fly    72 LDTELLRRNFEVVGKAIQHNTNVTDRMVATAINDLVFKESEEDWDALCSLAIQFGRPLFTNDSML 136
            |.::|.:.      ||.|.||::      ...|.:.|          |.|.:.|....:..:...
Mouse   138 LASDLGKE------KAKQLNTDM------NFFNPIAF----------CDLLLLFVGFNWVEEECK 180

  Fly   137 PFIDVTPKVVV---------------------------QKQRAPRK---------TKSQVDEKRP 165
            .|.|....:|:                           :.:|:.||         .|.:.....|
Mouse   181 EFSDCDDSIVLSFWGMLHEEATSWMLQAETFHFIFGSFKAERSARKPRLGCHKRACKMEGSGDMP 245

  Fly   166 EKSDQL------ERKDEGAASVTHMLKQIRQIYRDGNQEPIPYFKLICNPNNFMDTVQNALQLSF 224
            .|..:|      |..::....:..:|:...|.|.|   .|:.||:.:.:||:|..||:|...:||
Mouse   246 TKLRRLDVHANQETTEKEVERILGLLQTYFQKYPD---TPVSYFEFVIDPNSFSRTVENIFYVSF 307

  Fly   225 LVKENYISIENGEDGLPLVRVVNSKSVEGNAPSQAIC------SIDVTFCEKMVKHYNLHEPMLK 283
            ::::.:..|...:|.||::...|...|:..:.|.:.|      |:.:...:.:|..:.:.|.|:|
Mouse   308 IIRDGFARIRLDQDRLPILEPTNVSQVDDESDSYSYCRKQGVISLSLQDWKNIVSTFEISEAMIK 372

Fly 284 283
Mouse 373 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nse4	NP_001162938.1	Nse4_C	200..282	CDD:285900	21/87 (24%)
Eid3	NP_079775.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..68
		Nse4-Nse3_bdg	132..178	CDD:292054	14/67 (21%)
		Nse4_C	283..371	CDD:285900	21/87 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831621
Domainoid	1	1.000	53	1.000	Domainoid score	I11304
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002403
OrthoInspector	1	1.000	-	-		otm43445
orthoMCL	1	0.900	-	-		OOG6_102377
Panther	1	1.100	-	-	O	PTHR16140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.870