Protein Alignment Nse4 and EID3

DIOPT Version :10

• Sequence 1: NP_609405.2
• Gene: Nse4 / 34434
• FlyBaseID: FBgn0032251
• Length: 290
• Species: Drosophila melanogaster
• Sequence 2: NP_001008395.1
• Gene: EID3 / 493861
• HGNCID: 32961
• Length: 333
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 73/330 - (22%)
• Similarity: 135/330 - (40%)
• Gaps: 64/330 - (19%)

  Fly     3 SSESQSQMDDQDARILRLQNLIEKNIEIEQQI----------ENNTIGESITAIEEIIQTANDIS 57
            |.:..|...|.|.::|.|....||...|.:|.          ..:.:..:..::.|.::.||.:.
Human    13 SDDLSSGEADVDPKLLELTADEEKCRSIRRQYRQLMYCVRQNREDIVSSANNSLTEALEEANVLF 77

  Fly    58 KGHEDRRTNSTE---LVLDTELLRRNFEVVGKAIQHNTNVTDRMVATAINDLVFKE--------- 110
            .|....|..:.:   ||:.::|.:.      ||.|.|:::      ...|.|.|.:
Human    78 DGVSRTREAALDARFLVMASDLGKE------KAKQLNSDM------NFFNQLAFCDFLFLFVGLN 130

  Fly   111 -SEEDWDAL--C--SLAIQFGRPL-------FTNDSMLPFI-------DVTPKVVVQKQRAPRKT 156
             .|.|.|.|  |  |:|:.|.:.:       ........|:       ...||..::.|:..||.
Human   131 WMEGDPDKLSDCDDSIALSFWKAIEKEATSWMVKAETFHFVFGSFKLERSAPKPRLEHQKKVRKM 195

  Fly   157 KSQVDEKRPEKSDQLERKDEGAA---SVTHMLKQIRQIYRDGNQEPIPYFKLICNPNNFMDTVQN 218
            :.  :...|.|..:|:......|   :|..:|..::..:|.....|:.||:.:.:||:|..||:|
Human   196 EE--NGNMPTKLQKLDLSSYPEATEKNVERILGLLQTYFRKYPDTPVSYFEFVIDPNSFSRTVEN 258

  Fly   219 ALQLSFLVKENYISIENGEDGLPLVRVVNSKSV-EGNAPS-----QAICSIDVTFCEKMVKHYNL 277
            ...:||:|::.:..|...||.||::..:|...: |||..|     |.:.|:.:...:.:|..:.:
Human   259 IFYVSFIVRDGFARIRLDEDRLPILEPMNVNQMGEGNDSSCHGRKQGVISLTLQEWKNIVAAFEI 323

  Fly   278 HEPML 282
            .|.|:
Human   324 SEAMI 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nse4	NP_609405.2	Nse4_C	199..282	CDD:462585	26/88 (30%)
EID3	NP_001008395.1	Nse4-Nse3_bdg	89..145	CDD:464708	15/67 (22%)
		Nse4_C	239..328	CDD:462585	26/88 (30%)