DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STUB1 and TOM70

DIOPT Version :9

Sequence 1:	NP_477441.1	Gene:	STUB1 / 34433	FlyBaseID:	FBgn0027052	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_014278.3	Gene:	TOM70 / 855602	SGDID:	S000005065	Length:	617	Species:	Saccharomyces cerevisiae

Alignment Length:	231	Identity:	53/231 - (22%)
Similarity:	97/231 - (41%)	Gaps:	65/231 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LQLKEQGNCLFAARKYDDAINCYSKAI-IKNPTNATYFTNRALCNLKLKRWELCCQDSRRALDID 78
            |.||::||..|..:||||||..|:.|: :|.  :..:::|.:.|.:.:...:...:.|.:||::.
Yeast   100 LALKDKGNQFFRNKKYDDAIKYYNWALELKE--DPVFYSNLSACYVSVGDLKKVVEMSTKALELK 162

  Fly    79 ---GNLLKGHFFLGQGLMEIDN--FDEAIKHLQRAY-----------DLSKEQ----KQNFGD-- 121
               ..:|.......:||.:..:  ||.::..|...:           :|:|:.    |:.|||
Yeast   163 PDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLERNLNKQAMSKLKEKFGDID 227

  Fly   122 -------DITLQLRLARK-KRWNVME--------------------EKRIQQEIELQSYLNGLIK 158
                   :::.|....|| |:.|:..                    ::..:.:.||.:.|:.|.|
Yeast   228 TATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDESNEADKELMNGLSNLYK 292

  Fly   159 GDMES------------RLANLKLNGNVHDEQLKDK 182
            ...||            ||...:|:.|..||:||:|
Yeast   293 RSPESYDKADESFTKAARLFEEQLDKNNEDEKLKEK 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STUB1	NP_477441.1	TPR_11	17..78	CDD:290150	19/61 (31%)
		TPR	17..47	CDD:197478	14/30 (47%)
		TPR repeat	17..42	CDD:276809	13/25 (52%)
		TPR repeat	47..77	CDD:276809	5/29 (17%)
		TPR repeat	82..110	CDD:276809	6/40 (15%)
		U-box	213..285	CDD:252675
TOM70	NP_014278.3	3a0801s09	1..614	CDD:273380	53/231 (23%)
		TPR repeat	99..127	CDD:276809	14/26 (54%)
		TPR repeat	131..161	CDD:276809	5/29 (17%)
		TPR repeat	166..189	CDD:276809	4/22 (18%)
		TPR repeat	330..358	CDD:276809
		TPR repeat	363..391	CDD:276809
		TPR repeat	396..426	CDD:276809
		TPR repeat	431..459	CDD:276809
		TPR repeat	465..493	CDD:276809
		TPR repeat	498..537	CDD:276809
		TPR repeat	542..567	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840