DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STUB1 and stub1

DIOPT Version :9

Sequence 1:	NP_477441.1	Gene:	STUB1 / 34433	FlyBaseID:	FBgn0027052	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	XP_021325787.1	Gene:	stub1 / 324243	ZFINID:	ZDB-GENE-030131-2963	Length:	291	Species:	Danio rerio

Alignment Length:	286	Identity:	158/286 - (55%)
Similarity:	213/286 - (74%)	Gaps:	22/286 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QLKEQGNCLFAARKYDDAINCYSKAIIKNPTNATYFTNRALCNLKLKRWELCCQDSRRALDIDGN 80
            :||||||.||.:|||.:|:.||||||.:||:.|.|:||||||.:||::::....|.:.||::|..
Zfish    16 ELKEQGNRLFLSRKYQEAVTCYSKAINRNPSVAVYYTNRALCYVKLQQYDKALADCKHALELDSQ 80

  Fly    81 LLKGHFFLGQGLMEIDNFDEAIKHLQRAYDLSKEQKQNFGDDITLQLRLARKKRWNVMEEKRIQQ 145
            .:|.||||||..:|::|::|||.:|||||:|:|||:.||||||...||:|:|||||.:|||||.|
Zfish    81 SVKAHFFLGQCQLELENYEEAIGNLQRAYNLAKEQRLNFGDDIPSALRIAKKKRWNSIEEKRISQ 145

  Fly   146 EIELQSYLNGLIKGDMESRLANLKLNGNVHDEQLK---DKQ-----QEIEQECDDHIKELNNIFS 202
            |.||.:||:.||..:.|..|          |:::|   |.|     .:::.:.|.::.:::.:||
Zfish   146 ENELHAYLSKLILAEKEREL----------DDRVKQSDDSQNGGDISKMKSKHDKYLMDMDELFS 200

  Fly   203 KVDERRK----KREVPDFLCGKISFEILTDPVITPSGITYERKDIEEHLQRVGHFDPVTRVKLTQ 263
            :|||:||    |||:||:||||||||::.:|.||||||||:|||||||||||||||||||..|||
Zfish   201 QVDEKRKVVVQKREIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQ 265

  Fly   264 DQLIPNFSMKEVVDSFIAENEWSLDY 289
            ||||||.:||||:|:||.||.|..||
Zfish   266 DQLIPNLAMKEVIDAFIQENGWVEDY 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STUB1	NP_477441.1	TPR_11	17..78	CDD:290150	33/60 (55%)
		TPR	17..47	CDD:197478	20/29 (69%)
		TPR repeat	17..42	CDD:276809	17/24 (71%)
		TPR repeat	47..77	CDD:276809	13/29 (45%)
		TPR repeat	82..110	CDD:276809	16/27 (59%)
		U-box	213..285	CDD:252675	56/71 (79%)
stub1	XP_021325787.1	PLN03088	14..>191	CDD:330826	89/184 (48%)
		TPR repeat	14..42	CDD:276809	17/25 (68%)
		TPR repeat	47..77	CDD:276809	13/29 (45%)
		TPR repeat	82..109	CDD:276809	15/26 (58%)
		RING-Ubox_CHIP	215..281	CDD:319568	52/65 (80%)
		U-box domain, a modified RING finger	221..259	CDD:319568	31/37 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596384
Domainoid	1	1.000	129	1.000	Domainoid score	I5242
eggNOG	1	0.900	-	-		E1_KOG4642
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4281
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2480
OMA	1	1.010	-	-		QHG57751
OrthoDB	1	1.010	-	-		D1422450at2759
OrthoFinder	1	1.000	-	-		FOG0005678
OrthoInspector	1	1.000	-	-		oto40580
orthoMCL	1	0.900	-	-		OOG6_103776
Panther	1	1.100	-	-	LDO	PTHR46803
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3168
SonicParanoid	1	1.000	-	-		X4660
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800