Protein Alignment STUB1 and STUB1

DIOPT Version :10

• Sequence 1: NP_477441.1
• Gene: STUB1 / 34433
• FlyBaseID: FBgn0027052
• Length: 289
• Species: Drosophila melanogaster
• Sequence 2: NP_005852.2
• Gene: STUB1 / 10273
• HGNCID: 11427
• Length: 303
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 160/276 - (57%)
• Similarity: 211/276 - (76%)
• Gaps: 2/276 - (0%)

  Fly    16 QLKEQGNCLFAARKYDDAINCYSKAIIKNPTNATYFTNRALCNLKLKRWELCCQDSRRALDIDGN 80
            :||||||.||..|||.:|..||.:||.:||..|.|:||||||.||:::.|....|.||||::||.
Human    28 ELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALADCRRALELDGQ 92

  Fly    81 LLKGHFFLGQGLMEIDNFDEAIKHLQRAYDLSKEQKQNFGDDITLQLRLARKKRWNVMEEKRIQQ 145
            .:|.||||||..:|::::||||.:|||||.|:|||:.||||||...||:|:|||||.:||:||.|
Human    93 SVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQ 157

  Fly   146 EIELQSYLNGLIKGDMESRLANLKLN--GNVHDEQLKDKQQEIEQECDDHIKELNNIFSKVDERR 208
            |.||.|||:.||..:.|..|...:.|  |:..|..::.:|..||.:.|.::.:::.:||:|||:|
Human   158 ESELHSYLSRLIAAERERELEECQRNHEGDEDDSHVRAQQACIEAKHDKYMADMDELFSQVDEKR 222

  Fly   209 KKREVPDFLCGKISFEILTDPVITPSGITYERKDIEEHLQRVGHFDPVTRVKLTQDQLIPNFSMK 273
            |||::||:||||||||::.:|.||||||||:|||||||||||||||||||..|||:|||||.:||
Human   223 KKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMK 287

  Fly   274 EVVDSFIAENEWSLDY 289
            ||:|:||:||.|..||
Human   288 EVIDAFISENGWVEDY 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STUB1	NP_477441.1	TPR repeat	17..42	CDD:276809	15/24 (63%)
		TPR	21..>111	CDD:440225	49/89 (55%)
		TPR repeat	47..77	CDD:276809	16/29 (55%)
		TPR repeat	82..110	CDD:276809	16/27 (59%)
		CHIP_TPR_N	130..211	CDD:436460	35/82 (43%)
		RING-Ubox_CHIP	213..283	CDD:438316	53/69 (77%)
STUB1	NP_005852.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		0/1 (0%)
		Spy	25..>124	CDD:443119	53/95 (56%)
		TPR 1	26..59		18/30 (60%)
		TPR repeat	26..54	CDD:276809	15/25 (60%)
		TPR repeat	59..89	CDD:276809	16/29 (55%)
		TPR 2	60..93		18/32 (56%)
		TPR repeat	94..122	CDD:276809	16/27 (59%)
		TPR 3	95..127		19/31 (61%)
		Required for interaction with MAPK7. /evidence=ECO:0000269|PubMed:20724525	101..200		50/100 (50%)
		CHIP_TPR_N	142..225	CDD:436460	37/84 (44%)
		Required for interaction with and ubiquitination of MYOCD. /evidence=ECO:0000250|UniProtKB:A6HD62	142..196		24/55 (44%)
		Required for ubiquitination of FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..303		94/161 (58%)
		Required for interaction with FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..197		24/55 (44%)
		RING-Ubox_CHIP	227..297	CDD:438316	54/69 (78%)