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Protein Alignment TBC1D16 and RABGAP1L

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001353375.1	Gene:	RABGAP1L / 9910	HGNCID:	24663	Length:	1051	Species:	Homo sapiens

Alignment Length:	853	Identity:	164/853 - (19%)
Similarity:	266/853 - (31%)	Gaps:	326/853 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GDERLDRKIDIAYEDNEILFCKNNVCIHPPTIARDESDILHNPGYLTCTTKTFVDQY-------N 73
            |||:|::.::....|:|                :..|.:|     :.|.:.:.:..:       :
Human    51 GDEQLEKAMEEILRDSE----------------KRPSSLL-----VDCQSSSEISDHSFGDIPAS 94

  Fly    74 SAKRPTLLLTWIPNSSLCKYTNLNADDCRGQCNPRSKSP------DS-------RNGYCHVTIPQ 125
            ...:|:|.|...|::     |.::        .||..||      ||       ..|...|:.|
Human    95 QTNKPSLQLILDPSN-----TEIS--------TPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSP- 145

  Fly   126 TIQERDIREEDENAADMQELKNELQ-PLLGGQAASIDDLTALLKNNPITSVNI--TISNPQI--- 184
                   |.|.|....|..:|:..| |.         .:|..:.|.|..||.|  ..||.:|
Human   146 -------RNEVEALRAMATMKSSSQYPF---------PVTLYVPNVPEGSVRIIDQSSNVEIASF 194

  Fly   185 ------------------------ENSNISQSFN-------------------CITIRPDSNNCS 206
                                    |:|:.|:.|.                   |...:..|...|
Human   195 PIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVS 259

  Fly   207 DCTNGSGVGDG--PATDNPKWTTPELLAFKHNLEFPD---SGNSTPA--DRQKSAMKCRH----- 259
            |      |.|.  |..|:      ::..|..:||..:   .||.:|.  ||.|...|.:.
Human   260 D------VKDSVIPTPDS------DVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKLKQGIEKK 312

  Fly   260 FSVDLSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHF--------HYGGLDHLAQVLHQWH-- 314
            ..:.:.|:.:..|..  :.| .|.|:...|..:...:|.        .|.|..::  :...|:
Human   313 VVITVQQLSNKELAI--ERC-FGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYV--ITGMWNPN 372

  Fly   315 --CFLHNITSETGQDK-------FDL-------PYRHFM--VCR--------------------- 340
              .|| .:..||.:||       .|:       |.|..:  |.|
Human   373 APVFL-ALNEETPKDKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFF 436

  Fly   341 PEVKKSE-----------------------------------MHPDE---------------GDV 355
            ..:|:||                                   |.|.:               |||
Human   437 MRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDV 501

  Fly   356 KKITTN---FFYGTLLNEKGQIEDDLLLR----KCVFFGGLEKSLRKTVWPFLLKCYSFSSTFED 413
            .|....   :.:|.||   |:...:|..|    ..:...|:.::||..||..|..|:       |
Human   502 SKDCPEKILYSWGELL---GKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCH-------D 556

  Fly   414 RAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMK 478
            ...::|          |.|:.......|       :.|:.:|:.||...:.:|........|.:.
Human   557 NQAMLD----------RYRILITKDSAQ-------ESVITRDIHRTFPAHDYFKDTGGDGQESLY 604

  Fly   479 NILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLM--------QRAFFVCTPTDRD 535
            .|...::||:..:.|.||.| .||.||.....|.:.|...|.:|        .|..|      .|
Human   605 KICKAYSVYDEDIGYCQGQS-FLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNF------ED 662

  Fly   536 VDHNLSYLRELIRIMLPHFYKH-----LEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACW 595
            :......|..|::..||..:.|     ||.|      ::..:|.|..|..:|...:|..:.:...
Human   663 LHCKFYQLERLMQEQLPDLHSHFSDLNLEAH------MYASQWFLTLFTAKFPLCMVFHIIDLLL 721

  Fly   596 SNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILR-----KARGLLHQ 655
            ...|...||  :.||::....:|:    |:.|     |.....:...||..|     .||.|:.|
Human   722 CEGLNIIFH--VALALLKTSKEDL----LQAD-----FEGALKFFRVQLPKRYRAEENARRLMEQ 775

  Fly   656 YRQLPKIP 663
            ...: |:|
Human   776 ACNI-KVP 782

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.