Protein Alignment TBC1D16 and SGSM2

DIOPT Version :10

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_011522403.1
• Gene: SGSM2 / 9905
• HGNCID: 29026
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 956
• Identity: 179/956 - (18%)
• Similarity: 303/956 - (31%)
• Gaps: 420/956 - (43%)

  Fly     2 PIGSIIKKASSFILGDERL----DRKIDIAYEDN--EILFCKNNVCIHPPTIARDESDILHNPGY 60
            |...|.|:.||....::||    ...::..::::  .:|:.||:|.:.|      :.|:...|||
Human   267 PALGIRKRHSSGSASEDRLAACARECVESLHQNSRTRLLYGKNHVLVQP------KEDMEAVPGY 325

  Fly    61 LTCTTKTFVDQYNSAKRPTLLLTWIPNSSL---------------------------CKYTN--- 95
            |:.        :.||:  :|.|.|.||..:                           |.:.:
Human   326 LSL--------HQSAE--SLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQK 380

  Fly    96 --------------------------LNADDC-------RGQCNPRSKSPDSRNGYCHVTIPQTI 127
                                      |:...|       |||..|...:...:.    ...|:..
Human   381 SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKG----KVFPKLR 441

  Fly   128 QERDIREEDENAADMQEL-----------------KNE-----LQPLLGGQAASIDD-------L 163
            :...||     :.||:|:                 ::|     ...|...:|||:||       |
Human   442 KRSSIR-----SVDMEEMGTGRATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDEEEEDKL 501

  Fly   164 TALLKNNPITSVNITISNP------QIENSNISQSFNCITIRP---DSNNCSDCTNGSGVGDGPA 219
            .|:|  :.|.|.|:|..||      .||......|.....:.|   ..::|..|::.|
Human   502 HAML--SMICSRNLTAPNPMKDAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCSSSS------- 557

  Fly   220 TDNPKWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQL 284
                                  |.::||:          |.|. :.....|||.     |.|.:.
Human   558 ----------------------SPHATPS----------HCSC-IPDRLPLRLL-----CESMKR 584

  Fly   285 VIASRESQYKILHFHYGGLDHLAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPE----VKK 345
            .|.||.        .||.|.         ||                  ||....|..    |..
Human   585 QIVSRA--------FYGWLA---------HC------------------RHLSTVRTHLSALVHH 614

  Fly   346 SEMHPDE------GDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKC 404
            |.:.||.      |..|.:.:.:     ..:|...::..|||: |::||:|..:||.||||||..
Human   615 SVIPPDRPPGASAGLTKDVWSKY-----QKDKKNYKELELLRQ-VYYGGIEHEIRKDVWPFLLGH 673

  Fly   405 YSFSSTFEDRAVLMDIKRQEYEEI---------------------TRKRLYSMS----------- 437
            |.|..:.::...:..:....|:::                     ||.:..|.|
Human   674 YKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIH 738

  Fly   438 ------------------------------PEQQ------------------------------- 441
                                          |||:
Human   739 RDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRN 803

  Fly   442 ------------------------------------IHFWK------------------------ 446
                                                .|..:
Human   804 YSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAV 868

  Fly   447 -----TVQIV---------VEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGM 497
                 |::::         ::|||.|.||...:|   ..||.|.:::::.::...:..:.|.|||
Human   869 CAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYF---TPPNLERLRDVMCSYVWEHLDVGYVQGM 930

  Fly   498 SDLLAPVLCEVQNESETFWCFVGLMQRA---FFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLE 559
            .|||||:|..:.|:...:.||..||:|.   |    |....:|.:.:.:|.||:|:....::.:.
Human   931 CDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNF----PNGGAMDTHFANMRSLIQILDSELFELMH 991

  Fly   560 QHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWS--NYLTDYFHLFLCLAIIAVYADDVVAQ 622
            |:.|.....||:||.||.||||.....|..:||..|:  :..:::|.||:.||::..|.:.:...
Human   992 QNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDN 1056

  Fly   623 NLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQLPKIPCTLSG 668
            |:...:::..|:  |:::..|.:|...         :|:..|.|.|
Human  1057 NMDFTDIIKFFN--ALHVSPQNVLSIT---------MPRRSCGLPG 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	78/402 (19%)
SGSM2	XP_011522403.1	RUN	18..243	CDD:459241
		PH_RUTBC	302..470	CDD:275431	30/192 (16%)
		TBC	<885..1053	CDD:214540	55/174 (32%)