DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and Sgsm2

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001361617.1	Gene:	Sgsm2 / 97761	MGIID:	2144695	Length:	1050	Species:	Mus musculus

Alignment Length:	948	Identity:	190/948 - (20%)
Similarity:	302/948 - (31%)	Gaps:	412/948 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PIGSIIKKASSFILGDERL----DRKIDIAYEDN--EILFCKNNVCIHPPTIARDESDILHNPGY 60
            |...|.|:.||....::||    ...::..::::  .:|:.||||.:.|      :.|:...|||
Mouse   221 PALGIRKRHSSGSASEDRLAACAREYVESLHQNSRTRLLYGKNNVLVQP------KEDMEAVPGY 279

  Fly    61 LTCTTKTFVDQYNSAKRPTLLLTWIPN---------SSLCK-----------YTNLNADDC---- 101
            |:.        :.||:  .|.|.|.||         |.|.|           ::.:....|
Mouse   280 LSL--------HQSAE--NLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQIVCIHCHQQK 334

  Fly   102 ---------------------------------------RGQCNPRSKSPDSRNGYCHVTIPQTI 127
                                                   |||..|...:...:.    ...|:..
Mouse   335 SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKG----KVFPKLR 395

  Fly   128 QERDIREEDENAADMQEL-----------------KNE-----LQPLLGGQAASIDD-------L 163
            :...||     :.|::||                 ::|     ...|...:|||:||       |
Mouse   396 KRSSIR-----SIDVEELGVGRATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDEEEEDKL 455

  Fly   164 TALLKNNPITSVNITISNP------QIENSNISQSFNCITIRP---DSNNCSDCTNGSGVGDGPA 219
            .|:|  :.|.|.|:|..||      .||......|.....:.|   ..::|..|::.|.
Mouse   456 HAML--SMICSRNLTAPNPMKDAGDMIEMQGFGPSLTAWHLEPLCSQGSSCLSCSSSSS------ 512

  Fly   220 TDNPKWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQL 284
                .:.||     .|....||                         ...|||.     |.|.:.
Mouse   513 ----PYATP-----SHCSCIPD-------------------------RLPLRLL-----CESMKR 538

  Fly   285 VIASRESQYKILHFHYGGL----------DHLAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVC 339
            .|.||.        .||.|          .||:.::|      |||          :|
Mouse   539 QIVSRA--------FYGWLAYCRHLSTVRTHLSALVH------HNI----------IP------- 572

  Fly   340 RPEVKKSEMHPDE--GDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLL 402
                      ||.  |....:|.:.:.....:||...|.:||  :.|::||:|..:||.||||||
Mouse   573 ----------PDRPPGASGGLTKDVWSKYQKDEKNYKELELL--RQVYYGGVEHEIRKDVWPFLL 625

  Fly   403 KCYSFSSTFE-----DRAV---------------------------------------------- 416
            ..|.|..:.:     |.||
Mouse   626 GHYKFGMSKKEMEQVDTAVAARYQQVLAEWKACEVVVRQREREAHPATLTKFSSGSSIDSHVQRL 690

  Fly   417 -------------------------LMDIKRQEYEE------------------------ITRKR 432
                                     |.|.|.:..:|                        :...|
Mouse   691 VHRDSTISNDVFISVDDLEPSGPQDLEDSKPKREQEPGAGTPGIAAAEQQSVEFDSPDSGLPSSR 755

  Fly   433 LYSMS---------------------------PEQQIHFWK------------------------ 446
            .||::                           |....|.:.
Mouse   756 NYSVASGIQSSLDEAQSVGFEDDGAGEDGSEGPATAAHTFPGPHDPGQETLAPASELEAGQELAA 820

  Fly   447 ------TVQIV---------VEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQG 496
                  |::::         ::|||.|.||...:|   ...|.|.:::|:.::...:..|.|.||
Mouse   821 VCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYF---TTSNLERLRDIMCSYVWEHLDMGYVQG 882

  Fly   497 MSDLLAPVLCEVQNESETFWCFVGLMQRA---FFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHL 558
            |.|||||:|..:.|:...:.||..||:|.   |    |:...:|.:.:.:|.||:|:....::.:
Mouse   883 MCDLLAPLLVILDNDQLAYSCFSHLMKRMGQNF----PSGGAMDSHFANMRSLIQILDSELFELM 943

  Fly   559 EQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWS--NYLTDYFHLFLCLAIIAVYADDVVA 621
            .|:.|.....||:||.||.||||.....|..:||..|:  ...:::|.||:.||::..|.:.:..
Mouse   944 HQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARRISSEHFVLFIALALVEAYREIIRD 1008

  Fly   622 QNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQL 659
            .|:...:::..|:..|...|.|.|||.||.|:|:.:.|
Mouse  1009 NNMDFTDIIKFFNERAERHDAQEILRIARDLVHKVQML 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	82/401 (20%)
Sgsm2	NP_001361617.1	RUN	42..185	CDD:367169
		PH_RUTBC	256..424	CDD:275431	32/192 (17%)
		TBC	<838..1006	CDD:214540	56/174 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810