Protein Alignment TBC1D16 and MDR1

DIOPT Version :9

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_011614.1
• Gene: MDR1 / 852992
• SGDID: S000003332
• Length: 950
• Species: Saccharomyces cerevisiae
• Alignment Length: 532
• Identity: 98/532 - (18%)
• Similarity: 182/532 - (34%)
• Gaps: 140/532 - (26%)

  Fly   184 IENSNISQSFNCITIRPDSNNCSDCTNGSGVGDGPATDNPKWTTPELLAFKHNLEFPDSGNSTPA 248
            :|::|...||  .|...|....||..|..|...........:.||..|.|:...:
Yeast    44 LEDTNAEVSF--ATSIKDGKGHSDRVNNKGRKTAYVYSGRLFLTPHFLVFRDAFD---------- 96

  Fly   249 DRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHYGGLDHLAQVLHQW 313
              ..|.:...:.|......||                 .|...::.:|...|.|    |:||.|:
Yeast    97 --HSSCVLILNISTIKRVERS-----------------PSESYEFALLVTLYTG----AKVLIQF 138

  Fly   314 HCFLHNITSETGQDKFDL------------------PYRHFMVCRPEVKKSEMH-PDEGDVKKIT 359
            ....:.  ||...||..|                  .|..|::.:..:.|.::. |..|    :.
Yeast   139 IGIRYR--SEQFCDKLKLNLKENIPNAKTLPAFLETSYSEFLIAKNILGKKDITVPRAG----LG 197

  Fly   360 TNFFY---GTLLNEKGQIE----------------DDLLLRKCVFFGGLEKSLRKTVWPF----L 401
            .:|.|   .|::.||.::.                ...:.||.:.. |:...:|..:|..    :
Yeast   198 QHFKYPGNPTMVKEKAKLRLWFDYFRENGRNLAVVQTPMFRKLIRI-GVPNRMRGEIWELCSGAM 261

  Fly   402 LKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIV--VEKDVVRTDRTNP 464
            ...|:.|.              |||.|..:           :..||.|.:  :|||:.|:  ...
Yeast   262 YMRYANSG--------------EYERILNE-----------NAGKTSQAIDEIEKDLKRS--LPE 299

  Fly   465 FFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLMQ---RAF 526
            :.........:.::|:|..::..|..:.|.|.|:.::|..|. ..:|.:.|||...|..   ..:
Yeast   300 YSAYQTEEGIQRLRNVLTAYSWKNPDVGYCQAMNIVVAGFLI-FMSEEQAFWCLCNLCDIYVPGY 363

  Fly   527 FVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMW 591
            :..|.....:|..:  ....:...:|..::::.||:..:.::.. .|.|..|.........:|:.
Yeast   364 YSKTMYGTLLDQRV--FESFVEDRMPVLWEYILQHDIQLSVVSL-PWFLSLFFTSMPLEYAVRIM 425

  Fly   592 EACWSNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLL-----HFSSL--AMYMDGQLILRKA 649
            :..:.|.....|.  :.||::.:.|||::..:  .|.|.:     :|.:|  :.:.|...|
Yeast   426 DIFFMNGSITLFQ--VALAVLKINADDILQAD--DDGMFIAIIKHYFQTLGQSAHPDSSDI---- 482

  Fly   650 RGLLHQYRQLPK 661
                 :|||:.|
Yeast   483 -----KYRQITK 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	43/239 (18%)
MDR1	NP_011614.1	COG5210	23..531	CDD:227535	98/532 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810