Protein Alignment TBC1D16 and GYP7

DIOPT Version :10

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_010047.1
• Gene: GYP7 / 851364
• SGDID: S000002393
• Length: 746
• Species: Saccharomyces cerevisiae
• Alignment Length: 778
• Identity: 179/778 - (23%)
• Similarity: 288/778 - (37%)
• Gaps: 237/778 - (30%)

  Fly    31 NEILFCKNNVCIHPPTIARDESDILHNPGYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYTN 95
            ::|||||:.|.:||.:.|||     :..|:|..|.:.     |...... :|.:||.|.|   :.
Yeast     2 SKILFCKSKVFLHPTSDARD-----NIAGFLLLTLEA-----NKLSHQA-ILQYIPESGL---ST 52

  Fly    96 LNADDCRGQCNPRSKSPDSRNGYCHVTIPQTIQERDIREEDENAADMQELKNELQPLLGGQAASI 160
            |...        :....:::.|.|..:.|..|         ||:.:...|.|...    |||..|
Yeast    53 LEIS--------KLLKHEAKVGTCPTSTPFVI---------ENSINFSNLVNTSL----GQAFEI 96

  Fly   161 DDLTALLKNNPITSVNITISNPQIENSNISQSFNCITIRPDSNNCSDCTNGSGVGD---GPATDN 222
                                       ::||.: ||..||.|      .||..||.   .|.|:.
Yeast    97 ---------------------------SLSQIY-CIQFRPPS------PNGWYVGSLVIYPLTEQ 127

  Fly   223 PKWTTPELLAFKHNL----------------EFPDSGN------------STPADRQKSAMKCRH 259
            .....|.:|.|...|                .|.||..            :...:.:||.::...
Yeast   128 FTGFQPPVLFFHDQLCPSTTDKLKRLRKSMNPFDDSDELYWGGVDLRNKINELMELKKSNLEPEF 192

  Fly   260 FSVDLSQMRSLRLF--------FNDDNCTSGQLVIASRESQYKILHFHYGGLDHLAQV------- 309
            :.|:.| :..||.|        :|:....:.:|..|..:...|...:.:..:..:|.|
Yeast   193 WLVNPS-LNDLRNFVSKDLLESYNNSKKDTTELATAGVKLNEKFQEWKWNVMSKIADVTTKSTNF 256

  Fly   310 LHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDV------------------- 355
            :..|   |.| .|...:.:.|..|...::...:||:.|...|...|
Yeast   257 IDSW---LTN-NSPIQKSQIDNEYLQKLLNNEKVKQIEQDYDSARVYLANWSLGVKQEAERYQKQ 317

  Fly   356 ----KKITTNFFYGTLLNEKGQIEDDLL--------------------------------LRKCV 384
                .....|.|..  ||...::.|..:                                ::..:
Yeast   318 NKLFDSYRNNIFND--LNLTDELSDTEINNALQRQFPLTEAKWNSLWDENDGRLRVTVNEVKDFI 380

  Fly   385 FFGGLEK-SLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEIT---RKRLYSMSPEQQIHFW 445
            |.||||. |||..||.|||:.|.:.|:.::|..:......||:::.   .|.......|.:..:|
Yeast   381 FHGGLENDSLRGKVWGFLLEIYPWDSSQDERVQIDQTLAAEYDQLKLTWSKDFLQFDDEDEEEYW 445

  Fly   446 KTVQIVVEKDVVRTDR---------------------------TNPFFCGDD---------NPNT 474
            ......:.|||.|.||                           |:|....|:         ||:.
Yeast   446 NDQLFRISKDVRRCDRNLEIFQYNTIDGLPPPPQQLPANENNSTSPESANDESDDADDGVRNPHL 510

  Fly   475 EVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWC---FVGLMQRAFFVCTPTDRD- 535
            ..::|||:.:.||||.:.|.|||:|||:|:...::.|.:||||   |:.:|:|.|.      ||
Yeast   511 IHLQNILITYNVYNTNLGYVQGMTDLLSPIYVIMKEEWKTFWCFTHFMDIMERNFL------RDQ 569

  Fly   536 --VDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNY 598
              :...:..|.||:::|||...:||.: .||..|.||.|.||:.|||||....::.:||..|:.|
Yeast   570 SGIHEQMLTLVELVQLMLPELSEHLNK-CDSGNLFFCFRMLLVWFKREFEMEDIMHIWENFWTFY 633

  Fly   599 LTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMD-------GQLILRKARGLLH 654
            .:..|.||..|||:...:..::....:.|::|..|:.|...:|       .:|:.:|...::|
Yeast   634 YSSQFQLFFMLAILQKNSQAILQHLNQFDQILKFFNELNGKLDWNDLMVRAELLFKKFEKMMH 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	88/276 (32%)
GYP7	NP_010047.1	COG5210	134..738	CDD:227535	132/577 (23%)