DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1D16 and TBC1D10A

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001191169.1	Gene:	TBC1D10A / 83874	HGNCID:	23609	Length:	515	Species:	Homo sapiens

Alignment Length:	235	Identity:	45/235 - (19%)
Similarity:	86/235 - (36%)	Gaps:	48/235 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 GLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVV 452
            |:..|||...|.:|          ....|.:.....:::|:      .|||...  .|..   |:
Human   118 GIPPSLRGRAWQYL----------SGGKVKLQQNPGKFDEL------DMSPGDP--KWLD---VI 161

  Fly   453 EKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWC 517
            |:|:.|....:..|........:.:..:|..:.:|.....|.|..:.:.|.:|..:..| :.|||
Human   162 ERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAE-QAFWC 225

  Fly   518 FVGLMQRAF-------FVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLL 575
            .|.:.::..       ......|.::      |..|::.:.|..:|||.:.... .||:...|.:
Human   226 LVQICEKYLPGYYSEKLEAIQLDGEI------LFSLLQKVSPVAHKHLSRQKID-PLLYMTEWFM 283

  Fly   576 LCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAVY 615
            ..|.|....:.|:|:|:            :|.|..:..::
Human   284 CAFSRTLPWSSVLRVWD------------MFFCEGVKIIF 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	45/235 (19%)
TBC1D10A	NP_001191169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		TBC	117..320	CDD:214540	45/235 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..515
		ZipA	<403..>502	CDD:331990
		Binding to the PDZ domain of EBP50	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810