Protein Alignment TBC1D16 and sgsm2

DIOPT Version :10

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_068069810.1
• Gene: sgsm2 / 799094
• ZFINID: ZDB-GENE-131119-52
• Length: 1057
• Species: Danio rerio
• Alignment Length: 932
• Identity: 180/932 - (19%)
• Similarity: 297/932 - (31%)
• Gaps: 378/932 - (40%)

  Fly     2 PIGSIIKKASSFILGDERLDRK----IDIAYEDNEI--LFCKNNVCIHPPTIARDESDILHNPGY 60
            |...|.|:.||..:.:::....    ::..::::.:  |:.||||.:.|    :.:.::|.  ||
Zfish   226 PALGIRKRQSSGSMSEDKFAASAREYVESLHQNSRVHLLYGKNNVLVQP----KKDMEVLR--GY 284

  Fly    61 LTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYTNLNADDC------------------------ 101
            |:.        :.:|:  ||.|.|.||..:    |....||
Zfish   285 LSL--------HQTAE--TLTLKWTPNQLI----NGTLGDCDLEKSIYWDYALTVPLRQIVCIHC 335

  Fly   102 --------------------------------------------RGQCNP-----RSKSP----- 112
                                                        |||..|     |.|..
Zfish   336 HQRPDCGGTLVLVSQDGIQRPPLHFPPGGHLLAFLSCLETGLLPRGQLEPPLWSQRGKGKVFPKL 400

  Fly   113 DSRNGYCHVTIPQTIQERDIREEDENAADM------------QELKNELQPLLGGQAASIDD--- 162
            ..||....:.      ::|...||:.|||.            ..:........|.:|.|:||
Zfish   401 RKRNSTARLV------DQDGDGEDQIAADYVFRIVYPGHRHDSTVTINYHHSTGSRAPSLDDDEE 459

  Fly   163 ----LTALLKNNPITSVNITISNPQIENSNISQSFNCITIRPDSNNCSDCTNGSGVGDGPATDNP 223
                |.|::  :.|.|.|:|..|...::.::.:.                   .|.|..|.:
Zfish   460 EEDRLHAMI--SMICSRNLTDPNVMKDHGDLMEM-------------------QGFGGSPLS--- 500

  Fly   224 KWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIAS 288
             |...|..:...:.....:|.|..:....::..|.|..:.|..:           |.:.:..|.|
Zfish   501 -WQQGECTSHMSSCLSCSTGGSNASVELPASCTCMHDRIPLKML-----------CQNMKRQIVS 553

  Fly   289 RESQYKILHFHYGGL---DHLAQV-LHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMH 349
            |.        .||.|   .||:.| .|......|||.                   |..|..|.
Zfish   554 RA--------FYGWLAYCRHLSTVRTHLSALVNHNIV-------------------PPDKPCEA- 590

  Fly   350 PDEGDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDR 414
              .|.:.|...:.:.....|.|     :|.|.:.|::||:|..:||.||||||..|.|....::.
Zfish   591 --SGGLSKDVWSKYQKDCKNYK-----ELELLRLVYYGGVEHEIRKEVWPFLLGHYKFGMDKKNM 648

  Fly   415 AVLMDIKRQEYEEITRK------------------------------------------------ 431
            |.:.:.....|:::.|:
Zfish   649 AQIDEKITARYQQVMREWKACEVIVKQREKEMQSAIFAKLSSGSSIDSHVLRLIHRDSTISNEVF 713

  Fly   432 ---------------------------------------------------RLYSMSP------- 438
                                                               |.||::.
Zfish   714 MSVDEPDAGGQDTSCEDSTPTLTTVVTPAMLAPDERPLVEFDSPDSGLPSSRNYSVASGHSQIMS 778

  Fly   439 ------------------EQQ-----------------------------------IHFWKTVQI 450
                              |:|                                   |....||.:
Zfish   779 SIDDGQSMEEDTTPTGGLEEQGGRGSLSEDKLCSQLDKLTTTSSSEGTAPSFSSYTIELLDTVAL 843

  Fly   451 ---VVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNES 512
               .::|||.|.||...:|   .:.|.|.::||:.::...:..:.|.|||.|||||::..:.:|.
Zfish   844 NLHRIDKDVQRCDRNYYYF---TSSNLEKLRNIMCSYVWEHLEIGYVQGMCDLLAPLMVILDDEC 905

  Fly   513 ETFWCFVGLMQRA---FFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWL 574
            ..:.||..||:|.   |    ||...:|.:.:.:|.||:|:....::.:.|:.|.....||:||.
Zfish   906 LAYSCFTQLMRRMSQNF----PTGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 966

  Fly   575 LLCFKREFTEAVVIRMWEACW--SNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLA 637
            ||.||||.....|..:||..|  ....:.:|.||:.||::.||.|.::..|:...:::..|:.:|
Zfish   967 LLDFKRELLYEDVFAVWEVIWVAPRISSKHFVLFIALALVEVYRDIILDNNMDFTDIIKFFNEMA 1031

  Fly   638 MYMDGQLILRKARGLLHQYRQL 659
            ...|.|.|||.||.|:|:.:.|
Zfish  1032 ERHDVQHILRMARELVHKVQTL 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	81/397 (20%)
sgsm2	XP_068069810.1	RUN	19..201	CDD:459241
		PH_RUTBC	262..432	CDD:275431	34/195 (17%)
		TBC	<845..1014	CDD:214540	58/175 (33%)