Protein Alignment TBC1D16 and TBC1D17

DIOPT Version :10

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_078958.2
• Gene: TBC1D17 / 79735
• HGNCID: 25699
• Length: 648
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 152/570 - (26%)
• Similarity: 246/570 - (43%)
• Gaps: 112/570 - (19%)

  Fly   199 RPDSNNCSDCTNGSGVGDGPATD---NPKWTT-----PELLAFKHNLEFPDSGNSTPADRQKSAM 255
            :.||:....|.:    .:.|..|   .|.|..     |:|...:     |..| :.|:..|.|..
Human    64 KKDSSGGDSCAS----EEEPTFDPGYEPDWAVISTVRPQLCHSE-----PTRG-AEPSCPQGSWA 118

  Fly   256 KCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRE-SQYKILHFHYGGLDHLAQVLHQW------ 313
                |||.|.:::|:|.  :....:...||:.::. .....||||.||...|.:||.::
Human   119 ----FSVSLGELKSIRR--SKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASS 177

  Fly   314 ------------------HCFLH---------NITSETGQDKFDLPYRHF----------MVCRP 341
                              :.|.|         |:.|...||.:...:..|          :..:|
Human   178 PQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQP 242

  Fly   342 EVKKSEMHPDEGDVKK---------------------ITTNFFYGTLLNEKGQIEDDLLLRKCVF 385
            |...|::.|...|..:                     ..|...:...:..:|:::....|:..:|
Human   243 EGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIF 307

  Fly   386 FGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLY--SMSPEQQ-----IH 443
            .|||..|||:..|.|||...|:..|.|:....:   |::.:|..|.:|.  |:||||:     :|
Human   308 SGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHI---RKKTDEYFRMKLQWKSVSPEQERRNSLLH 369

  Fly   444 FWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEV 508
            .:::   ::|:||.||||||.|:.|.:||...::.:|||.:.:|:..:.|.|||||||:|:|..:
Human   370 GYRS---LIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVI 431

  Fly   509 QNESETFWCFVGLMQRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRW 573
            |||.:.||||.|.|:........:...:...|..|..|:|::.|.....|:. .||..|.||.||
Human   432 QNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDS-QDSGSLCFCFRW 495

  Fly   574 LLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAM 638
            ||:.|||||....|:|:||..|:.......||.:..||:.:..|.::......:|:|.|.:.|.|
Human   496 LLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTM 560

  Fly   639 YMDGQLILRKARGLLHQYRQLPKIPCTLS---GLCKRCGPGMWDSEHRPA 685
            .:..:.:|.:|..|..|....|::|..:.   ||.....|      |.|:
Human   561 KLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEP------HSPS 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	88/237 (37%)
TBC1D17	NP_078958.2	PH_RBD	7..205	CDD:432305	33/156 (21%)
		Required for interaction with OPTN. /evidence=ECO:0000269|PubMed:22854040	218..309		11/90 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..259		5/18 (28%)
		TBC	307..542	CDD:214540	90/241 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..648		4/17 (24%)