DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1D16 and Tbc1d9b

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001277689.1	Gene:	Tbc1d9b / 76795	MGIID:	1924045	Length:	1263	Species:	Mus musculus

Alignment Length:	626	Identity:	117/626 - (18%)
Similarity:	202/626 - (32%)	Gaps:	239/626 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYTNLNADDCRGQCNPRSKSPDSRNGYCHVTI 123
            |:..||..|   .:|....|..:  :|.|:.:|.               .||..|:    |.:.|
Mouse   304 GHTGCTLWT---PFNKLHIPGQM--FISNNYICF---------------ASKEEDA----CRLII 344

  Fly   124 PQTIQERDIREEDENAADMQ-----ELKNELQPLLGGQAASIDD-------LTALLKNNP----- 171
            |  ::|..|.|:.::::.:.     ..|:::..|.    |::.|       ::..|:..|
Mouse   345 P--LREVTIVEKADSSSVLPSPLSISTKSKMTFLF----ANLKDRDFLVQRISDFLQKTPSKQTG 403

  Fly   172 --ITSVNITISNPQIENSNISQSFNCITIRPDSNNCSDCTNGSGVGDGPATDNPKWTTPE----- 229
              |.....::|:|..|:....|..:.....|.|               |.:..|.::|.|
Mouse   404 SSIGGTKASVSDPAPESLPTPQEASEPPASPSS---------------PLSSPPSFSTQEIPTTS 453

  Fly   230 ---LLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRES 291
               |..|:.|....|.|    |...|..||                                 |.
Mouse   454 QGLLKVFQKNSPMEDLG----AKGAKEKMK---------------------------------EE 481

  Fly   292 QYKILHFHYG-GLDHLAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDV 355
            .:.|..|.|| |:                                   |.....|:.
Mouse   482 SWNIHFFEYGRGM-----------------------------------CMYRTAKTR-------- 503

  Fly   356 KKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDI 420
                                 :|:|:      |:.:|||..:|  ||    ||..:.:    |..
Mouse   504 ---------------------ELVLK------GIPESLRGELW--LL----FSGAWNE----MVT 531

  Fly   421 KRQEYEEITRKRL--YSMSPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLN 483
            ....|.|:..|.|  ||::.|:           :|:|:.|:...:|.|  .:......::.:|..
Mouse   532 HPGYYAELVEKSLGKYSLATEE-----------IERDLHRSMPEHPAF--QNELGIAALRRVLTA 583

  Fly   484 FAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLMQRA---FFVCTPTDRDVDHNLSYLRE 545
            :|..|..:.|.|.| :::..||....:|.|.||..|.|.:|.   ::........||..:  ..|
Mouse   584 YAFRNPTIGYCQAM-NIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGI--FEE 645

  Fly   546 LIRIMLPHFYKHLEQHN--DSMELLFCHRWLLLCF--KREFTEAVVIRMWEACWSNYLTDYFH-- 604
            |.|.:||...:.:::..  .|:.|    .|.|..|  ...|..||||          :..:|:
Mouse   646 LTRDVLPRLSEKMQELGVISSISL----SWFLTLFLSVMPFESAVVI----------VDCFFYEG 696

  Fly   605 ----LFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMD 641
                |.:.||::....:.::..|...:.|.:    |..|:|
Mouse   697 IKVILQVALAVLDANVEQLLDCNDEGEAMTV----LGRYLD 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	58/245 (24%)
Tbc1d9b	NP_001277689.1	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	299..394	CDD:270161	22/119 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..449		11/66 (17%)
		TBC	506..716	CDD:214540	59/255 (23%)
		EFh	<856..907	CDD:298682
		EFh	887..912	CDD:197492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	977..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1139..1159
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900