DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and Tbc1d9

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001104774.1	Gene:	Tbc1d9 / 71310	MGIID:	1918560	Length:	1264	Species:	Mus musculus

Alignment Length:	652	Identity:	121/652 - (18%)
Similarity:	211/652 - (32%)	Gaps:	231/652 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLC---KYTNL--------------NADDCRGQCN 106
            |:..||..|   .:|  |...|...::..:.:|   |..||              .||.|....:
Mouse   309 GHTDCTLWT---PFN--KMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKADSCSVLPS 368

  Fly   107 PRSKSPDSRNGYCHVTIPQTIQERDIREEDENAADMQELKNELQPLLGGQAASIDDLTALLKNNP 171
            |.|.|..:|..:...    .:::||..        :|.:.:.||           ..|:.:.::.
Mouse   369 PLSISTRNRMTFLFA----NLKDRDFL--------VQRISDFLQ-----------QTTSRIYSDK 410

  Fly   172 ITSVNITISNPQIENSNISQSFNCITIRPDSNNCSDCTNGSGVGDGPATDNPKWTTPELLAFKHN 236
            ..|.:...|:.::    .|:..:.::..|..:..||..     |:.|
Mouse   411 EFSGSCNSSDDEV----YSRPSSLVSSSPQRSTSSDAD-----GERP------------------ 448

  Fly   237 LEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHYG 301
              |..:|||.|...|......|..|.:....:..:.|.              :|..:|| ||
Mouse   449 --FNLNGNSVPTATQTLMTMYRRRSPEEFNPKLAKEFL--------------KEQAWKI-HF--- 493

  Fly   302 GLDHLAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGT 366
                                :|.||.          :|....:|:.
Mouse   494 --------------------AEYGQG----------ICMYRTEKTR------------------- 509

  Fly   367 LLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRK 431
                      :|:|:      |:.:|:|..:|..|      |....::|.    ....||.:..|
Mouse   510 ----------ELVLK------GIPESMRGELWLLL------SGAINEKAT----HPGYYEGLVEK 548

  Fly   432 RL--YSMSPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYS 494
            .:  |:::.|:           :|:|:.|:...:|.|  .:......::.:|..:|..|..:.|.
Mouse   549 SMGKYNLATEE-----------IERDLHRSLPEHPAF--QNEMGIAALRRVLTAYAFRNPNIGYC 600

  Fly   495 QGMSDLLAPVLCEVQNESETFWCFVGLMQRA---FFVCTPTDRDVDHNLSYLRELIRIMLPHFYK 556
            |.| :::..||.....|.|.||..|.|.:|.   ::........||..:  ..||.|..:|..|
Mouse   601 QAM-NIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGV--FEELARDYVPQLY- 661

  Fly   557 HLEQHNDSMELL-----FCHRWLLLCF--KREFTEAVVIRMWEACWSNYLTDYFH-----LF-LC 608
                  |.|:.|     ....|.|..|  ...|..|||:          :..:|:     :| |.
Mouse   662 ------DCMQDLGVISTISLSWFLTLFLSVMPFESAVVV----------VDCFFYEGIKVIFQLA 710

  Fly   609 LAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQLPKIPCTLSGLCKRC 673
            ||::....|.::  |.:.|...:  :.|..|:|         .:.::...||.||...|.|....
Mouse   711 LAVLDANVDKLL--NCKDDGEAM--TVLGRYLD---------SVTNKDSTLPPIPHLHSLLSDDV 762

  Fly   674 GP 675
            ||
Mouse   763 GP 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	54/248 (22%)
Tbc1d9	NP_001104774.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	21/106 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..456		11/74 (15%)
		TBC	512..722	CDD:214540	56/258 (22%)
		EFh	<893..923	CDD:298682
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1119..1162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900