Protein Alignment TBC1D16 and Tbc1d2b

DIOPT Version :9

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_919315.2
• Gene: Tbc1d2b / 67016
• MGIID: 1914266
• Length: 965
• Species: Mus musculus
• Alignment Length: 520
• Identity: 99/520 - (19%)
• Similarity: 186/520 - (35%)
• Gaps: 146/520 - (28%)

  Fly   129 ERDIREEDENAADMQE----------LKNELQPLLGGQAASIDDLTALLKNNPITSVNITISNPQ 183
            ::::|.......::.|          .|:|:...|.....|:...|.    .|.:.:.|..|..|
Mouse   425 QQEVRTLKSKVGELNERLGMLMETIQAKDEVIIKLSACEGSVSSPTL----GPSSPLAIPASKDQ 485

  Fly   184 IENSNISQSFNCITIRPDSNNCSDCTNGSGVGDGPATDNPKWTTPELL---AFKHNLEFPDSGNS 245
            :|...:..|.                      .|..:.| |:...|:|   |.:.|
Mouse   486 LELDRLKDSL----------------------QGYKSQN-KFLNKEILELSALRRN--------- 518

  Fly   246 TPADRQKSAMKCRHFSVD--LSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHYG-GLDHLA 307
              |:|::..:..::.|::  |.|:.|             :.:|..:|.:..:.....| ..|.:|
Mouse   519 --AERRERDLMAKYSSLEAKLCQVES-------------KYLILLQEMKTPVCSEEQGPARDVIA 568

  Fly   308 QVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITT------------ 360
            |:|..   .|...:.|..:..|..|:   :|...::......||:.:.:|:..
Mouse   569 QLLED---ALQVESQEQPEQAFVKPH---LVSEFDIYGFRTVPDDDEEEKLVAKVRALDLKTLYL 627

  Fly   361 -------------NFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFE 412
                         |:|..| :|.:.....:|   |.:...|:....|..||.:.:
Mouse   628 TDNQEVSTGVKWENYFAST-MNREMACSPEL---KNLIRAGIPHEHRSKVWKWCV---------- 678

  Fly   413 DRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVVEK----------DVVRTDRTNPFFC 467
            ||.             |||...||.|:   :|...:|..:||          |::||...|..:.
Mouse   679 DRH-------------TRKFKDSMEPD---YFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYS 727

  Fly   468 GDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGL----MQRAFFV 528
            ...:...:.::::||.|:..|..:.|.||::.|:|..|..:..| :.|||.|.:    |.|.::.
Mouse   728 SPTSEGIQKLRSVLLAFSWRNPDIGYCQGLNRLVAVALLYLDQE-DAFWCLVTIVEVFMPRDYYT 791

  Fly   529 CTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEA 593
            .|.....||..:  .|:|:...||..:.|.||:.....|: ...|.|:.|.......::.::|::
Mouse   792 KTLLGSQVDQRV--FRDLLSEKLPRLHTHFEQYKVDYTLI-TFNWFLVVFVDSVVSDILFKIWDS 853

  Fly   594  593
            Mouse   854  853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	52/221 (24%)
Tbc1d2b	NP_919315.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		PH_TBC1D2A	36..144	CDD:269966
		PH	38..136	CDD:278594
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..288
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..340
		HIP1_clath_bdg	<341..>378	CDD:293123
		RabGAP-TBC	710..878	CDD:278964	36/148 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810