Protein Alignment TBC1D16 and TBC1D2

DIOPT Version :9

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001254500.1
• Gene: TBC1D2 / 55357
• HGNCID: 18026
• Length: 928
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 119/604 - (19%)
• Similarity: 194/604 - (32%)
• Gaps: 211/604 - (34%)

  Fly   128 QERD-------IREEDENAADMQELKNELQPLLGGQAASIDDLTALLKNNPITSVNITISNPQIE 185
            |||:       :||:     .:|||:..:|.|:.             ||:....|...:|
Human   381 QERESLAHTASLREQ-----QVQELQQHVQLLMD-------------KNHAKQQVICKLS----- 422

  Fly   186 NSNISQSF----NCITIRPDSNNCSDCTNGSGVGDGPATDNPKWTTPELLAFKHNLEFPDSGN-- 244
             ..::|.|    :...:|||:.| .|..:..|..:....|...:.|.....   |.|......
Human   423 -EKVTQDFTHPPDQSPLRPDAAN-RDFLSQQGKIEHLKDDMEAYRTQNCFL---NSEIHQVTKIW 482

  Fly   245 STPADRQKS---------AMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHY 300
            ...|:::|:         |..|:..|..|:.:|.|:....|:.....:|
Human   483 RKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSEL---------------- 531

  Fly   301 GGLDHLAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYG 365
              |..|.|...||.      ..|...|..:|        .|..|..|                ||
Human   532 --LRQLVQEALQWE------AGEASSDSIEL--------SPISKYDE----------------YG 564

  Fly   366 TLLNEKGQIEDDLLLRKC--------------------------------------VFFGGLEKS 392
            .|.....::||..||.|.                                      :...|:.:.
Human   565 FLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPRE 629

  Fly   393 LRKTVWPFLLK----------CYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKT 447
            .|..||.:|:.          ||.                   |.::|.:.......:||
Human   630 HRPRVWRWLVHLRVQHLHTPGCYQ-------------------ELLSRGQAREHPAARQI----- 670

  Fly   448 VQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNES 512
                 |.|:.||...|..|....:...:.::.:||.|:..|..:.|.||::.|.|..|..::.|.
Human   671 -----ELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEE 730

  Fly   513 ETFWCFVGLMQR---AFFVC-TPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRW 573
            ..|||.|.:::.   |.:.| |.|...||..:  |::|:...||....||.||:..:.|: ...|
Human   731 SAFWCLVAIVETIMPADYYCNTLTASQVDQRV--LQDLLSEKLPRLMAHLGQHHVDLSLV-TFNW 792

  Fly   574 LLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAM 638
            .|:.|.......:::|:|:|          .|:....::..||..:...|.:.
Human   793 FLVVFADSLISNILLRVWDA----------FLYEGTKVVFRYALAIFKYNEKE------------ 835

  Fly   639 YMDGQLILRKARGL-LHQY 656
                  |||...|| ::||
Human   836 ------ILRLQNGLEIYQY 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	56/244 (23%)
TBC1D2	NP_001254500.1	Interaction with CADH1	1..169
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39
		PH_TBC1D2A	47..147	CDD:269966
		PH	47..139	CDD:278594
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..275
		Interaction with RAC1. /evidence=ECO:0000269|PubMed:20116244	295..433		16/75 (21%)
		TBC	625..837	CDD:214540	57/271 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810