Protein Alignment TBC1D16 and TBC1D8B

DIOPT Version :9

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_060222.2
• Gene: TBC1D8B / 54885
• HGNCID: 24715
• Length: 1120
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 122/647 - (18%)
• Similarity: 191/647 - (29%)
• Gaps: 261/647 - (40%)

  Fly    12 SFILGDERLDRKIDIAYED--------NEILFCKNNVC-----------IH------------PP 45
            ||:||.|   .|:.|::::        |.||....:||           :|            ..
Human   189 SFLLGSE---IKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQTYLLMEQLANY 250

  Fly    46 TIAR-------DESDILHNPGYLT---CTTKTFVDQYN---------SAKRPTLLLTWIPNSSLC 91
            .|.|       |...:|:||..:|   ...:...:|:|         |.|.......|:|.|
Human   251 AIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLKEVHECFLWVPFS--- 312

  Fly    92 KYTNLNADDCRGQCNPRSKSPDSRNGYCHVTIPQTIQERDIREEDE------------------- 137
             :.|.:...|..:......|.|...  |.|.||.    |::...|:
Human   313 -HFNTHGKMCISENYICFASQDGNQ--CSVIIPL----REVLAIDKTNDSSKSVIISIKGKTAFR 370

  Fly   138 --NAADMQELKNELQPLLGGQAASIDDLTALLKNNPITSVNITISNPQIENSNISQSFNCITIRP 200
              ...|.::|..:|:...|..:....|:          |..:.||:   |::..|.:|...:: .
Human   371 FHEVKDFEQLVAKLRLRCGAASTQYHDI----------STELAISS---ESTEPSDNFEVQSL-T 421

  Fly   201 DSNNCSDCTNGSGVGDGPATDNPKWTTPELLAFKH--NLEFPDSGNSTPADRQKSAMKCRHFSVD 263
            ....||...|                |..|:...|  |||..:|      ...|..||
Human   422 SQRECSKTVN----------------TEALMTVFHPQNLETLNS------KMLKEKMK------- 457

  Fly   264 LSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHYGGLDHLAQVLHQWHCFLHNITSETGQDK 328
                                      |..:|||....|                      .|...
Human   458 --------------------------EQSWKILFAECG----------------------RGVSM 474

  Fly   329 FDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSL 393
            |            ..||:.                             ||::|      |:.::|
Human   475 F------------RTKKTR-----------------------------DLVVR------GIPETL 492

  Fly   394 RKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRL--YSMSPEQQIHFWKTVQIVVEKDV 456
            |..:|..      ||....|.|...|.    |.|:..:.|  .:::.|:           :|:|:
Human   493 RGELWML------FSGAVNDMATNPDY----YTEVVEQSLGTCNLATEE-----------IERDL 536

  Fly   457 VRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGL 521
            .|:...:|.|..|  .....::.:|..:|..|..:.|.|.| ::|..||.....|.|.||..|.:
Human   537 RRSLPEHPAFQSD--TGISALRRVLTAYAYRNPKIGYCQAM-NILTSVLLLYAKEEEAFWLLVAV 598

  Fly   522 MQRA---FFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHN--DSMELLFCHRWLLLCF 578
            .:|.   :|........||.  :...||||..||...:|:....  .|:.|    .|.|..|
Human   599 CERMLPDYFNRRIIGALVDQ--AVFEELIRDHLPQLTEHMTDMTFFSSVSL----SWFLTLF 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	49/199 (25%)
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419	14/67 (21%)
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	18/101 (18%)
		TBC	486..694	CDD:214540	50/205 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1066

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810