DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and Sgsm1

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_006535185.1	Gene:	Sgsm1 / 52850	MGIID:	107320	Length:	1148	Species:	Mus musculus

Alignment Length:	967	Identity:	188/967 - (19%)
Similarity:	304/967 - (31%)	Gaps:	418/967 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ILFCKNNVCIHPPTIARDESDILHNPGYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYTNLN 97
            :|:.||||.:.|    ||:.:.:  ||||:......|          :.|.|.||..:    |.:
Mouse   256 LLYGKNNVLVQP----RDDMEAV--PGYLSLHQTADV----------MTLKWTPNQLM----NGS 300

  Fly    98 ADD------------------------CRGQCNPRSKSPDSRNGYCHVTIPQTIQERDIREEDEN 138
            ..|                        |..|.:         :|...|.:.|...:|......:.
Mouse   301 VGDLDYEKSVYWDYAVTIRLEEIVYLHCHQQVD---------SGGTVVLVSQDGIQRPPFRFPKG 356

  Fly   139 AADMQELK---------NELQPLLGGQAASIDDLTALLKNNPITSVNITISNPQIENS------- 187
            ...:|.|.         .:|.|.|..|.........|.|.:|..|...|.|:.:.:.:
Mouse   357 GHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSSESTSSDKEDDEATDYVFRI 421

  Fly   188 -------------------------------------------NISQSFNCITI----------- 198
                                                       ..:|:..|:||
Mouse   422 IYPGTQSEFVALDLMGSPRPVSIGPAWMMLAAGQSMLVVAKGLQWAQTRGCLTIPTRSVKEQPPM 486

  Fly   199 ------------------RPDSNNCSDCTNGSGVGDGPAT--------------DNPKWTTPELL 231
                              .|..::||.|:. ||..||.:|              ||.|:   ::|
Mouse   487 PQDLMDVSMNNLPPLWQPSPRKSSCSSCSQ-SGSADGGSTNGCNHERAPLKLLCDNMKY---QIL 547

  Fly   232 --AFKHNLEFPDSGNSTPADRQKSAMKCRHFS---VDLSQMRSLRLFFNDDNCTSGQLVIASRES 291
              ||...|.:                 |||.|   ..||.:.:..:...|..|.:||.:.||...
Mouse   548 SRAFYGWLAY-----------------CRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTASIWE 595

  Fly   292 QY----------KILH-FHYGG-------------LDH--------------------LAQVLHQ 312
            :|          ::|. .:|||             |.|                    .||.:.:
Mouse   596 KYIQDSTTYPEQELLRLIYYGGVQPEIRRAVWPFLLGHYQFGMTEMERKEVDEQIHACYAQTMSE 660

  Fly   313 W--------------------------------HCFLH---NITSETGQ---------------- 326
            |                                |..||   .|::|:.|
Mouse   661 WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNLRLQSDSS 725

  Fly   327 ---------DKFDLPYRHFMVCRPEVKKSEMH--------------PDEGDVKKITTNFFYG--- 365
                     |:.:       ....|.:..|.|              ||.|...  :.||..|
Mouse   726 SSTQVFESVDEVE-------QTEAEGRSEEKHPKIPNGNPANGTCSPDSGHPS--SHNFSSGLSE 781

  Fly   366 ----------TLLN----------------EKGQ---------------------IEDDLLLRKC 383
                      ::|:                |.||                     :|.|||..:.
Mouse   782 HSEPSLSTEDSVLDAQRSLPAVFRPGDSSVEDGQSSEATTSRDEAPREELAVQDSLESDLLANES 846

  Fly   384 V--FF---GGLEKSLRK------TVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLY--- 434
            :  |.   |.|:.:|.:      ..||          ...|:....|.:....||...:.|:
Mouse   847 LEEFMSIPGSLDVALPEKDGAVMDGWP----------GEADKPSRADSEDNLSEEPEMESLFPAL 901

  Fly   435 ---------------------SMSPEQQIHFWKTVQI-VVEKDVVRTDRTNPFFCGDDNPNTEVM 477
                                 :.|||....:  ||.: .:||||.|.||:..:|..   .|.|.:
Mouse   902 ASLAVTSSANNEASPVSSSGVTYSPELLDLY--TVNLHRIEKDVQRCDRSYWYFTA---ANLEKL 961

  Fly   478 KNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLMQRA---FFVCTPTDRDVDHN 539
            :||:.::...:..:.|.|||.|||||:|..:.:|:..|.||..||:|.   |    |....:|.:
Mouse   962 RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNF----PHGGAMDTH 1022

  Fly   540 LSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWS--NYLTDY 602
            .:.:|.||:|:....::.:.|:.|.....||:||.||.||||.....|..:||..|:  :..:.:
Mouse  1023 FANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFSVWETIWAAKHVSSAH 1087

  Fly   603 FHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQL 659
            :.||:.||::.||.|.::..|:...:::..|:.:|...:.:.||:.||.|:|:.:.|
Mouse  1088 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNAKQILQLARDLVHKVQIL 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	73/266 (27%)
Sgsm1	XP_006535185.1	RUN	44..186	CDD:367169
		PH_RUTBC	254..425	CDD:275431	37/197 (19%)
		TBC	<936..1105	CDD:214540	59/175 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810