DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and tbc1d16

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001006076.2	Gene:	tbc1d16 / 450056	ZFINID:	ZDB-GENE-041010-179	Length:	717	Species:	Danio rerio

Alignment Length:	739	Identity:	314/739 - (42%)
Similarity:	437/739 - (59%)	Gaps:	102/739 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPIGSIIKKASS----FI-----LGDERLDRKIDIAYEDNEILFCKNNVCIHP--PTIARDESDI 54
            |..|.::::|||    |:     .|..|       :..|.||:|.|||||:||  |.....|
Zfish     1 MSFGRLLRRASSKASDFLTFNVGTGGSR-------SVLDGEIIFSKNNVCVHPAEPLPGLPE--- 55

  Fly    55 LHNPGYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYTNLNADDCRGQCNPRSKSPDSRNGYC 119
             |:|||| |......:...|    ||:|||:|||.:.:...........:.:|..::|..|....
Zfish    56 -HHPGYL-CVHLEKDETLGS----TLILTWVPNSRIQRQDEEALRYITPESSPVRRNPRRRAHRS 114

  Fly   120 HVTIPQTIQERDIREEDENAADMQELKNELQPLL-----GGQAASIDDLTALLKNNPITSVNITI 179
            |...|..       .|:|.|||.:..:.:.|.||     |....|.|:::   :::.|.|.:.|.
Zfish   115 HSRPPAA-------PEEEEAADEEGQEPQNQALLEEGDEGSCELSADEVS---RDSTIGSDSDTF 169

  Fly   180 SNP---QIENSNISQSFNCITIRPDSNNC-------------------SDCTNGSGVGDGPATDN 222
            |:|   ...:..:.:|.:.:.:..:|..|                   |:.::..||
Zfish   170 SSPFCLSPVSEALGESSSSVFLDNESRECDEPMAHSASSASSLDSHAPSESSHSQGV-------- 226

  Fly   223 PKWTTPE-LLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVI 286
             :|...: ::|.:|                    .|..|.|||..||||||||:|:.||.|||||
Zfish   227 -RWEEQQNVMALEH--------------------LCGVFRVDLGHMRSLRLFFSDEACTCGQLVI 270

  Fly   287 ASRESQYKILHFHYGGLDHLAQVLHQWHCFLH-NITSETGQDKFDLPYRHFMVCRPEVKKSEMHP 350
            |||||||||||||:.|||.||:|..||.|... .:..:...:|..:   .|.:.||.:..:||||
Zfish   271 ASRESQYKILHFHHAGLDKLAEVFQQWKCCRETQLKDQVSDEKSCM---QFSIRRPTLPSAEMHP 332

  Fly   351 DEGDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRA 415
            :|...:::..:.:. ..||..||:.::..|||.:||||::.|:|..||||||..||:.||.|:|.
Zfish   333 EERLYRRLDVSSWL-RHLNNSGQVLEEYKLRKAIFFGGIDPSIRGEVWPFLLHYYSYDSTSEERE 396

  Fly   416 VLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNI 480
            .....||.||::|.::|| |||||:...||:.||..|:||||||||:|.||.|::|||.|:|:.|
Zfish   397 AWRLQKRGEYQDIQQRRL-SMSPEEHSEFWRKVQFTVDKDVVRTDRSNMFFRGENNPNVEIMRRI 460

  Fly   481 LLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLMQRAFFVCTPTDRDVDHNLSYLRE 545
            |||:||:|..|.|.||||||:||:|.|:|:||:|||||||||:...|:.:|.|.|::..|.||||
Zfish   461 LLNYAVFNPDMGYCQGMSDLVAPLLTEIQDESDTFWCFVGLMENTIFISSPRDEDMERQLMYLRE 525

  Fly   546 LIRIMLPHFYKHLEQ-HNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCL 609
            |:|:|||.|::||.: ..|.::|||||||:||||||||.:|..:|||||||::|.|||||||||:
Zfish   526 LLRLMLPRFHQHLTRLGEDGLQLLFCHRWVLLCFKREFPDAEALRMWEACWAHYQTDYFHLFLCV 590

  Fly   610 AIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQLPKIPCTLSGLCKRCG 674
            |||.:|.|||..|.|..|:||||||:|:|:|:|:|:|||||.||:|:|.||:|||:|..|||.||
Zfish   591 AIIVLYGDDVTEQQLATDQMLLHFSNLSMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCG 655

  Fly   675 PGMWDSEHRPALECVG-HSDDEKC 697
            ||||||.:.||:||.| |.|.:.|
Zfish   656 PGMWDSRYIPAIECSGEHPDSQSC 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	136/231 (59%)
tbc1d16	NP_001006076.2	TBC	368..596	CDD:214540	135/228 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595418
Domainoid	1	1.000	294	1.000	Domainoid score	I1477
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10380
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1076
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	1	1.000	-	-		FOG0006347
OrthoInspector	1	1.000	-	-		oto41517
orthoMCL	1	0.900	-	-		OOG6_109412
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3820
SonicParanoid	1	1.000	-	-		X2505
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790