DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1D16 and CG42795

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001287272.1	Gene:	CG42795 / 41252	FlyBaseID:	FBgn0261928	Length:	3213	Species:	Drosophila melanogaster

Alignment Length:	345	Identity:	75/345 - (21%)
Similarity:	136/345 - (39%)	Gaps:	68/345 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 GGLEKSLRKTVWPFL----LKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKT 447
            ||.....|:.:|..|    ||..:.....:......:..|::.||:                  .
  Fly   220 GGTPPEFRRKLWLSLADKYLKSKNVDWAQQREKCFCEEWREDDEEL------------------G 266

  Fly   448 VQIVVEKDVVRTDR---TNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQ 509
            :|||  ||:.||..   |.|    ..:.|...:|.|||.:|.||..:.|.||.:.|.|.:|..:.
  Fly   267 IQIV--KDLHRTGSNLCTGP----AGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMD 325

  Fly   510 NESE-----TFWCFVGLMQRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSME--- 566
            .|.|     ..:...|::...:|..:......|  :...|||::..||...|||::....:|
  Fly   326 KEEEESMKVMIYLVEGVLPTGYFYGSMGGLQAD--MGVFRELMQTRLPRLAKHLQRLQGPVENAF 388

  Fly   567 -----LLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAII--AVYADDVVAQNL 624
                 .:|..:|.|..|......:.|:|:|:.    .|.:...:.|..|::  ::..:.|::..
  Fly   389 EPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDL----VLIEGSDVLLRTALVLWSLLEERVISVR- 448

  Fly   625 RPDEMLLHFSSLAMY----MDGQLILRKARGLLHQYRQLPKIPCTLSGLCKRCGPGMWDSEHRPA 685
            ..||.   :..:..|    ::|.|:  .:.||:.:..:|..|. .|..|..:....:....|:..
  Fly   449 SADEF---YGKMGSYSSELLNGHLV--DSNGLIERVVKLGPIE-DLRQLRDKHLYNIAPLRHKQG 507

  Fly   686 LECV-----GHSDDEKCSLS 700
            |:..     .|||:|:.:::
  Fly   508 LQLYYDEEDTHSDEERLAVA 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	57/252 (23%)
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:278964	47/186 (25%)
		DUF4682	560..684	CDD:292361
		DBP	1112..1415	CDD:289157
		SWIRM-assoc_2	<2376..2482	CDD:293105
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830