DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and plx

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster

Alignment Length:	761	Identity:	143/761 - (18%)
Similarity:	254/761 - (33%)	Gaps:	255/761 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FILG--DERL---DRKIDIAYEDNEILFCKNNVCIHPP-------TIARDESDILHNPGYL---- 61
            |::|  |.||   |||..:.|:|    |.....|:|..       .|.|:    |:|.||:
  Fly   526 FLVGRCDLRLISPDRKQVLLYKD----FKDVASCVHGQKSLDHFGIICRE----LNNDGYIGYVF 582

  Fly    62 --------------------TCTTK-----------------------TFVDQYNSAKRPTLLLT 83
                                ||..:                       |.|:..:..|...|:|.
  Fly   583 KCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILR 647

  Fly    84 WIPNSSLCKYTNLNADDCRGQCNPRSKSP-DSRNGYCHVTIPQTIQERDIREEDENAADMQELKN 147
            .|...|..:...:.|..|..:   ::.|| ..:|.:..:.:....:.|..|...:.|.:..|..|
  Fly   648 RIETLSDDEQEIVWAKFCGSE---KTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLN 709

  Fly   148 ELQPLLGGQAASIDDLTALLKNNPITSVNITISNPQIENSNISQSF-NCITIRPD-------SNN 204
            :   .|||.       |..:|                ...:::.|| |.:..:|.       |:|
  Fly   710 Q---YLGGS-------TIFMK----------------AKRSLTNSFDNLLKRKPSKDDIAVPSHN 748

  Fly   205 CSDCTNGSGVGDGPATDNPKWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRS 269
            ..|...||....|  |.:|    ||....:.|.......:...|::.||.|
  Fly   749 LRDIREGSAEPLG--TQSP----PEGFRSRSNTVGASPSSKPTAEQLKSPM-------------- 793

  Fly   270 LRLFFNDDNCTSGQLVIASRESQYKILHFHYGGLDHLAQVLHQWHCFLHN--ITSETGQD----- 327
            :.:|....|        :.:|::     .|.|          .|...:.|  :|...|.|
  Fly   794 MDIFIKVGN--------SPKEAE-----THQG----------SWRQAILNSVVTPSKGLDSEVPT 835

  Fly   328 KFDLPYRH-----------------------FMVCRPEVKKS--EMHPDEGDVKKITTNFFYGTL 367
            :|..|.|.                       .|:.|.|.:.:  :...:|.::|:|..:  |..:
  Fly   836 EFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLD--YEEI 898

  Fly   368 LN-EKGQIE--DDLLLRKCVFFG--------------GLEKSLRKTVWPFLLKCYSFSSTFEDRA 415
            :. :|..||  :.::.|.....|              |:.:|.|..||.||.:.:|.::
  Fly   899 VPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNT------ 957

  Fly   416 VLMDIKR-QEYEEITRKRLYSMSPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKN 479
            ..:|.|| ..:.......|..::..|...|         .|:.||...:.|:..........:.|
  Fly   958 APVDTKRFPNFNTPYHMLLKHLTEHQHAIF---------IDLGRTFPNHQFYKDPLGLGQLSLFN 1013

  Fly   480 ILLNFAVYNTGMSYSQGMSDLLAPVL--CEVQNESETFWCFVGLM----QRAFFVCTPTDRDVDH 538
            :|..:::.:..:.|.||:..:...:|  |:   |:.:|.....||    .|..::  |..:....
  Fly  1014 LLKAYSILDPELGYCQGLGFICGVLLLHCD---EANSFQLLKHLMFRRNMRTKYL--PDMKKFQL 1073

  Fly   539 NLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYF 603
            .|..|..|::..||..|..|:| ||....|:...|:|..|..:|....|.|:::.
  Fly  1074 QLYQLSRLVKDHLPDLYVWLDQ-NDVSPTLYAAPWILTVFSSQFPLGFVARVFDL---------- 1127

  Fly   604 HLFL---------CLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYM 640
             |||         .:|:::|:...::|::        :|..:..|:
  Fly  1128 -LFLESSDVIFKFAIALLSVHKQQLLAKD--------NFEEIMDYL 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	54/260 (21%)
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	19/82 (23%)
		DUF3350	835..880	CDD:288663	6/44 (14%)
		TBC	933..1152	CDD:214540	53/250 (21%)
		RILP-like	<1176..1267	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940