DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1D16 and Tbc1d2

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_006538109.1	Gene:	Tbc1d2 / 381605	MGIID:	2652885	Length:	923	Species:	Mus musculus

Alignment Length:	452	Identity:	90/452 - (19%)
Similarity:	155/452 - (34%)	Gaps:	104/452 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 NSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDD--NCTSGQLVIASRESQYKILHFHYGGLD-H 305
            ::|..|......:..|...|:...|:...|.|.:  ..|.....:|.:|   |.|......|. .
Mouse   438 DATNGDFLSQQERMEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKE---KALLTKCAYLQAR 499

  Fly   306 LAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGTLLNE 370
            ..||..::...|..:....|.:..|.|.....:.:..::......|...:..::....||.|...
Mouse   500 NCQVESKYLAGLRRLQEAAGAEAGDFPELLQQLIQEALQWEAGEADSVGLSPVSEYDDYGFLTVP 564

  Fly   371 KGQIEDDLLLRKC--------------------------------------VFFGGLEKSLRKTV 397
            ..::||..||.|.                                      :...|:.:..|..|
Mouse   565 DYEMEDLKLLAKIQALEVRSHHLLAHEAVERPLRDRWATLTELTPSAELKQLLRAGVPREHRPRV 629

  Fly   398 WPFLLK----------CYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVV 452
            |.:|:.          ||.                   |.:.|.|.......:||
Mouse   630 WRWLVHRRVRHLQAPGCYQ-------------------ELLARGRACEHPAARQI---------- 665

  Fly   453 EKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWC 517
            |.|:.||..||..|....:...:.::.:||.|:..|..:.|.||::.|.|..|..:::|...|||
Mouse   666 ELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWC 730

  Fly   518 FVGLMQ----RAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCF 578
            .|.:::    ..::..|.|...||..:  |::|:...||....||.||...:.|: ...|.|:.|
Mouse   731 LVAIVETILPAEYYSKTLTASQVDQRV--LQDLLSEKLPRLTAHLGQHRVDLSLI-TFNWFLVVF 792

  Fly   579 KREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHF-SSLAMY 639
            .......:::|:|:|          .|:....::..||..:...|   :|.:|.. .||.:|
Mouse   793 ADSLISDILLRVWDA----------FLYEGTKVVFRYALAIFKYN---EEAILQLQDSLEIY 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	56/244 (23%)
Tbc1d2	XP_006538109.1	PH_TBC1D2A	45..146	CDD:269966
		PRK14951	<192..404	CDD:237865
		COG4913	<300..>565	CDD:227250	23/129 (18%)
		TBC	620..832	CDD:214540	58/256 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900