DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1D16 and TBC1D10C

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001356427.1	Gene:	TBC1D10C / 374403	HGNCID:	24702	Length:	454	Species:	Homo sapiens

Alignment Length:	242	Identity:	53/242 - (21%)
Similarity:	83/242 - (34%)	Gaps:	44/242 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 GLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVV 452
            |:..:||...||.|...:          |........|:|:...   ...|:     |..   .:
Human    92 GIPSALRARCWPLLCGAH----------VCQKNSPGTYQELAEA---PGDPQ-----WME---TI 135

  Fly   453 EKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDL-------LAPVLCEVQN 510
            .:|:.|....:..|........:.:..:|..:.:|.....|.|....:       |.|..|.:..
Human   136 GRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEACALPL 200

  Fly   511 ESETFWCFVGLMQRAFFVCT--------PTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMEL 567
            ..|.|||.|.       :|.        |....|..:......|:|.:|||.:|||:|.... .|
Human   201 PQEAFWCLVQ-------ICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVG-PL 257

  Fly   568 LFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAV 614
            |:...|.|..|.|......|:|:|:|..|......|.:.|.|..:|:
Human   258 LYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLAL 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	53/242 (22%)
TBC1D10C	NP_001356427.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		TBC	89..302	CDD:214540	52/238 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..454
		Interaction with calcineurin	414..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810