DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and tbc

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	178/969 - (18%)
Similarity:	292/969 - (30%)	Gaps:	453/969 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ILFCKNNVCIHPPTIARDESDILHNPGYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYT--- 94
            :|:.||||.:.|..:|..      .||||:      :.|:..    ||.:.|.||..:..||
  Fly   294 LLYGKNNVQVLPKDVAEP------MPGYLS------LHQHIQ----TLTIKWTPNQLMNGYTEAE 342

  Fly    95 ---------------NLNADD-----CRGQCNPRSKSPDSRNGYCHVTIPQT-IQERDIREEDEN 138
                           |:|.|:     |.     :|:..||  |...:.:.|. :|...|...:
  Fly   343 EAEDIDKDAFWAYALNINVDEIVYVHCH-----QSRGEDS--GGTVILVGQDGVQRPPIHFPE-- 398

  Fly   139 AADMQEL----------KNELQPLLGGQAA---------------------SIDDLTALLKNNPI 172
            ...||:.          ..:|.|.|..|..                     |:|:       .||
  Fly   399 GGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESVDE-------TPI 456

  Fly   173 TSVNITISNPQIENSNISQSF--------------NCITIRPDSNNCSDCTNGSGVGDGPATDNP 223
            ..|...:|..:.|....:.|.              :|.|     ...|||:|.|     .:.|..
  Fly   457 DYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCST-----TGSSDCSNKS-----LSIDQF 511

  Fly   224 KWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIAS 288
            ...:|.:|             .....:|:..::.:..|:::.             |::.:..|.|
  Fly   512 PMESPLIL-------------QQQQQQQQQLLQAQSTSIEMV-------------CSTMRRQIIS 550

  Fly   289 RESQYKILHFHYGGL---DHLAQVLHQWHCFLH-NITSETGQDKFDLPYRHFMVCRPEVKKSEMH 349
            |.        .||.|   .||:.|.......:| .||                   ||:|..|
  Fly   551 RA--------FYGWLAYCRHLSTVRTHLSGLVHGRIT-------------------PEMKADE-- 586

  Fly   350 PDEGDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDR 414
              ||..|:      ...|||..|.:|:.....:.|:|||::..||:.|||:||..|:|.||.|||
  Fly   587 --EGLTKE------RWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDR 643

  Fly   415 ----------------------------------------------------------------- 414

  Fly   644 KKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLEN 708

  Fly   415 AVLMDI----------------------------------------------------------- 420
            .|..||
  Fly   709 EVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEP 773

  Fly   421 -------KRQEYEEITR--------KRLYS----------------------------------- 435
                   |:|:.|:|:.        ::|..
  Fly   774 DEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSV 838

  Fly   436 MSPEQ---------------------------------QIHFWK--------------------- 446
            :|||.                                 .|..|:
  Fly   839 LSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGES 903

  Fly   447 ----------------------------TVQIV---------VEKDVVRTDRTNPFFCGDDNPNT 474
                                        :.:::         :||||.|.||...:|.   |.|.
  Fly   904 GGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFA---NENL 965

  Fly   475 EVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLMQRAF--FVCTPTDRDVD 537
            :.::|::..:...:..:.|.|||.||:||:|....:||.::.||..||:|..  |   |:...:|
  Fly   966 DKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF---PSGGAMD 1027

  Fly   538 HNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWS--NYLT 600
            .:.:.:|.||:|:....|..::.:.|.....||:||.||.||||.....|...||..|:  :..:
  Fly  1028 MHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIAS 1092

  Fly   601 DYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQL 659
            .:|.|||.||::..|.|.:::.::...:::..|:.:|...:.|.:|:.||.|:.|.:.:
  Fly  1093 GHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMI 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	86/499 (17%)
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	42/203 (21%)
		TBC	923..1087	CDD:214540	50/169 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456504
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840