DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and Tbc1d2

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_006238118.1	Gene:	Tbc1d2 / 313234	RGDID:	1306860	Length:	924	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	91/461 - (19%)
Similarity:	160/461 - (34%)	Gaps:	105/461 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 NLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDD--NCTSGQLVIASRESQYKILHF 298
            :|..|...::|..|......:..|...|:...|:...|.|.:  ..|.....:|.:|   |.|..
  Rat   430 DLAQPQPADATNGDFLSQQERLEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKE---KALLT 491

  Fly   299 HYGGLD-HLAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVK-KSEMHPDEGDVKKITTN 361
            ....|. ...||..::...|..:....|.:..|.|.....:.:..:: ::....|...:..::..
  Rat   492 KCAYLQARNCQVESKYLAGLRRLQEAAGAEPGDFPELLQQLVQEALQWEAGEASDSVGLSPVSEY 556

  Fly   362 FFYGTLLNEKGQIEDDLLLRKC--------------------------------------VFFGG 388
            ..||.|.....::||..||.|.                                      :...|
  Rat   557 DDYGFLTVPDYEVEDLKLLAKIQALEVRSHHLLALEAVERPLRDRWATLTELMPSAELKQLLRAG 621

  Fly   389 LEKSLRKTVWPFLLK----------CYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIH 443
            :.:..|..||.:|:.          ||.                   |.:.|.|.......:||
  Rat   622 VPREHRPRVWRWLVHRRVQHLHSSGCYQ-------------------ELLARGRACEHPAARQI- 666

  Fly   444 FWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEV 508
                     |.|:.||..||..|....:...:.::.:||.|:..|..:.|.||::.|.|..|..:
  Rat   667 ---------ELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVL 722

  Fly   509 QNESETFWCFVGLMQ----RAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLF 569
            ::|...|||.|.:::    ..::..|.|...||..:  |::|:...||....||.|.:..:.|:
  Rat   723 EDEESAFWCLVAIVETILPAEYYSKTLTASQVDQRV--LQDLLSEKLPRLTAHLGQRHVDLSLI- 784

  Fly   570 CHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHF- 633
            ...|.|:.|.......:::|:|:|          .|:....::..||..:...|   :|.:|..
  Rat   785 TFNWFLVIFADSLISDILLRVWDA----------FLYEGTKVVFRYALAIFKYN---EEAILRLQ 836

  Fly   634 SSLAMY 639
            .||.:|
  Rat   837 DSLEIY 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	55/244 (23%)
Tbc1d2	XP_006238118.1	PH_TBC1D2A	44..145	CDD:269966
		PH	44..137	CDD:278594
		TBC	621..833	CDD:214540	57/256 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900