DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and Rabgap1

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001101311.1	Gene:	Rabgap1 / 311911	RGDID:	1304691	Length:	1065	Species:	Rattus norvegicus

Alignment Length:	757	Identity:	144/757 - (19%)
Similarity:	226/757 - (29%)	Gaps:	281/757 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LDRKI--DIA-YEDNEILFCKNNVCIHPPTIARDESDI-----------LHNPGYLTCTTKTFVD 70
            ||.:|  :|| |...:||||...   |..|   .|||.           |.......|..:..|.
  Rat   195 LDPQINTEIANYPIYKILFCVRG---HDGT---PESDCFAFTESHYNAELFRIHVFRCEIQEAVS 253

  Fly    71 QY---------NSAKRPTLLLT---WIPNSSLCKYT---NLNADDCRG-----------QCNPRS 109
            :.         .|||:..|..|   ..|:|.:..::   .:..||.:|           ||....
  Rat   254 RILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEIKEDDGKGYFSAVPKDKDRQCFKLR 318

  Fly   110 KSPDSRNGYCHVTIPQTIQE---------------RDIREEDENAADMQ---------------- 143
            :..|.:...|   :.||..:               :|:|..|.:..|::
  Rat   319 QGIDKKIVIC---VQQTANKELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKSYVITGS 380

  Fly   144 --------ELKNELQP----LLGGQAASIDDLTALLKNNPI-----TSVNITISNPQI------- 184
                    ::.||..|    |....|.   ||.......|:     |.|.:...|.::
  Rat   381 WNPKSPHFQVVNEETPKDKVLFMTTAV---DLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKR 442

  Fly   185 -ENSNISQSFNCITIRPDSNNCSDCTNGSGVGDGPATDNPKWTTPELLAFKHNLEFPDSGN---- 244
             ...|.......|..:...||.........:......:..|.|.      ..::..|.||:
  Rat   443 STTENFFLKLKQIKQKEKKNNADTLYEVVCLESESERERRKTTA------SPSVRLPQSGSQSSM 501

  Fly   245 --STPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHYGGLDHLA 307
              |.|.|.::..                    ||:...|| ....|:|...||       |:...
  Rat   502 IPSPPEDDEEED--------------------NDEPLLSG-FGDVSKECAEKI-------LETWG 538

  Fly   308 QVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGTLLNEKG 372
            ::|.:||..|:                    .||:...|
  Rat   539 ELLSKWHLNLN--------------------VRPKQLSS-------------------------- 557

  Fly   373 QIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMS 437
                  |:|     .|:.::||..||..|..|::.....|...:|          ||::     |
  Rat   558 ------LVR-----SGVPEALRGEVWQLLAGCHNNDHLVEKYRIL----------ITKE-----S 596

  Fly   438 PEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLA 502
            |:..         .:.:|:.||...:.:|........:.:..|...::||:..:.|.||.| .||
  Rat   597 PQDS---------AITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQS-FLA 651

  Fly   503 PVLCEVQNESETFWCFVGLM----QRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKH-----L 558
            .||.....|.:.|...|.:|    .|..|  .....|:......|..|::..:|..|.|     |
  Rat   652 AVLLLHMPEEQAFSVLVKIMFDYGLRELF--KQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISL 714

  Fly   559 EQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFH---LFLCLAIIAVYADDVV 620
            |.|      ::..:|.|..|..:|...:|               ||   |.||..|..::  :|.
  Rat   715 EAH------MYASQWFLTLFTAKFPLYMV---------------FHIIDLLLCEGISVIF--NVA 756

  Fly   621 AQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYR-QLPK 661
            ...|:..:             ..|:|....|.|..:| ||||
  Rat   757 LGLLKTSK-------------DDLLLTDFEGALKFFRVQLPK 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	54/242 (22%)
Rabgap1	NP_001101311.1	PTB_Rab6GAP	141..269	CDD:269922	20/79 (25%)
		DUF3694	303..433	CDD:403614	20/135 (15%)
		TBC	559..768	CDD:214540	57/276 (21%)
		ERM	790..1016	CDD:395622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900