DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and Sgsm1

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_017453793.1	Gene:	Sgsm1 / 288743	RGDID:	1308178	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	905	Identity:	185/905 - (20%)
Similarity:	299/905 - (33%)	Gaps:	349/905 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ILFCKNNVCIHPPTIARDESDILHNPGYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYTNLN 97
            :|:.||||.:.|    ||:.:.:  ||||:......|          :.|.|.||..:    |.:
  Rat   259 LLYGKNNVLVQP----RDDMEAV--PGYLSLHQTADV----------MTLKWTPNQLM----NGS 303

  Fly    98 ADD------------------------CRGQCNPRSKSPDSRNGYCHVTIPQTIQERDIREEDEN 138
            ..|                        |..|.:         :|...|.:.|...:|......:.
  Rat   304 VGDLDYEKSVYWDYAVTIRLEEIVYLHCHQQVD---------SGGTVVLVSQDGIQRPPFRFPKG 359

  Fly   139 AADMQELK---------NELQPLLGGQAASIDDLTALLKNNPITSVNITISN------------- 181
            ...:|.|.         .:|.|.|..|.........|.|.:|..|...|.|:
  Rat   360 GHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSSESTSSDKEDDEATDYVFRI 424

  Fly   182 --PQIENSNISQSFNCITIR---------PDSNNCSDCTNGSGVGDGPAT--------------D 221
              |..::..:.|....:::.         |..::||.|:. ||..||.:|              |
  Rat   425 IYPGTQSEFVPQDLMDVSMNNLPSLWQPSPRKSSCSSCSQ-SGSADGSSTNGCNHERAPLKLLCD 488

  Fly   222 NPKWTTPELL--AFKHNLEFPDSGNSTPADRQKSAMKCRHFS---VDLSQMRSLRLFFNDDNCTS 281
            |.|:   ::|  ||...|.:                 |||.|   ..||.:.:..:...|..|.:
  Rat   489 NMKY---QILSRAFYGWLAY-----------------CRHLSTVRTHLSALVNHMIVSPDLPCDA 533

  Fly   282 GQLVIASRESQY----------KILH-FHYGG-------------LDH----------------- 305
            ||.:.||...||          ::|. .:|||             |.|
  Rat   534 GQGLTASIWEQYIQDSTTYPEQELLRLIYYGGVQPEIRRAVWPFLLGHYQFGMTEMERKEVDEQI 598

  Fly   306 ---LAQVLHQW--------------------------------HCFLH---NITSETGQ------ 326
               .||.:.:|                                |..||   .|::|:.|
  Rat   599 HACYAQTMSEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGR 663

  Fly   327 -------------------DKFDLPYRHFMVCRPEVKKSEMH--------------PDEG----- 353
                               |:.:       ....|.:..|.|              ||.|
  Rat   664 QNLRLQSDSSSSTQVFESVDEVE-------QTEAEGRSEEKHPKIPNGNPANGTCSPDSGHPSSH 721

  Fly   354 ---------------------DVKK-ITTNFFYGTLLNEKGQ---------------------IE 375
                                 ||:: :...|..|....|.||                     :|
  Rat   722 NFSSGLSEHSEPSLSTEDSVLDVQRSLPAVFRPGDSSVEDGQSSEATTSRDEAPREELAVQDSLE 786

  Fly   376 DDLLLRKCV--FF---GGLEKSLRK------TVWPFLLKCYSFSSTFEDRAVLMDIKRQEYE--- 426
            .|||..:.:  |.   |.|:.:|.:      ..||       ..:....||...|...:|.|
  Rat   787 SDLLANESLEEFMSIPGSLDVALPEKDGAMMDGWP-------GEADKHGRADSEDNLSEEPEMES 844

  Fly   427 --------EITRKRLYSMSPEQQIHFWKTVQIV---------VEKDVVRTDRTNPFFCGDDNPNT 474
                    .:|.......||........:.:::         :||||.|.||:..:|..   .|.
  Rat   845 LFPALASLAVTSSANNETSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRSYWYFTA---ANL 906

  Fly   475 EVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLMQRA---FFVCTPTDRDV 536
            |.::||:.::...:..:.|.|||.|||||:|..:.:|:..|.||..||:|.   |    |....:
  Rat   907 EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNF----PHGGAM 967

  Fly   537 DHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWS--NYL 599
            |.:.:.:|.||:|:....::.:.|:.|.....||:||.||.||||.....|..:||..|:  :..
  Rat   968 DTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFSVWETIWAAKHVS 1032

  Fly   600 TDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQL 659
            :.::.||:.||::.||.|.::..|:...:::..|:.:|...:.:.||:.||.|:|:.:.|
  Rat  1033 SAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNAKQILQLARDLVHKVQIL 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	71/261 (27%)
Sgsm1	XP_017453793.1	RUN	44..186	CDD:397055
		PH_RUTBC	257..428	CDD:275431	37/197 (19%)
		TBC	<884..1053	CDD:214540	59/175 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810