DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and gyp7

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_592900.1	Gene:	gyp7 / 2543609	PomBaseID:	SPAC630.05	Length:	743	Species:	Schizosaccharomyces pombe

Alignment Length:	848	Identity:	186/848 - (21%)
Similarity:	293/848 - (34%)	Gaps:	323/848 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DRKIDIAYEDNEI--LFCKNNVCIHPPTIARDESDILHNPGYLTCTTKTFVDQYNSAKRPTLLLT 83
            |..:||..:::::  ||.|:.|.:||.:..:|...     |||:.:....:.. :|.....:||:
pombe    17 DDTVDIHIDNSKVALLFSKSKVFVHPTSKMKDNIS-----GYLSLSKSKALGN-SSVAGSDILLS 75

  Fly    84 WIPNSSLCKYTNLNADDCRGQCNPRSKSPDSRNGYCHVTIPQTIQERDIREEDENAADMQELKNE 148
            |:|:|.|             :..||..|....        .:|:....|||
pombe    76 WVPDSFL-------------KNRPRDLSVFQN--------AETLSNGSIRE-------------- 105

  Fly   149 LQPLLGGQAASIDDLTALLKNNPITSVNITISNPQIENSNISQSFN---C----ITIRPDSNNCS 206
                                         .:..||    ::..||:   |    |..||
pombe   106 -----------------------------WVEIPQ----HLDYSFSVRLCSIYSIIFRP------ 131

  Fly   207 DCTNGSGVGDGPATDNPK--WTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRS 269
                            |:  |....::     :...|||.|.|.
pombe   132 ----------------PRYGWNYGSIV-----INLRDSGESLPP--------------------- 154

  Fly   270 LRLFFNDDNCTS----GQLVIASRESQYKILHFHYGGLDHLAQVL----------HQWHCFLHNI 320
              |||:||.|.|    |:.:...|...:......:.|..||...|          |:...:|.|.
pombe   155 --LFFHDDECISTIEYGKQITRDRFDPFDESGNMFWGGTHLLMQLKKYASLEQSSHESQLYLVNP 217

  Fly   321 TSET----------------------------------------------------------GQD 327
            :.|.                                                          |:.
pombe   218 SPEDTVAFQSVELQKVISNNRLNSSSTPPTPRSSSSIFNPFRRALHDLSFTVLERFSRVTNYGKS 282

  Fly   328 KFD-----------LPY--RHFMVC----RPEVKKSEMHP--------DEGDVKKITTNFF---- 363
            :.|           ||:  |...|.    |.:....|..|        .||.|::..:|..
pombe   283 EVDRLMEHKVTKSILPHLPRELQVLLESKRVQKLTEEYDPARMFLARWAEGIVEQSESNNSQPVN 347

  Fly   364 --------------------------------------YGTLLNEKGQIEDDL-LLRKCVFFGGL 389
                                                  :.::.|..|:::.|: .:...:|.||:
pombe   348 NAGVWTDAQREEDSSLGPFELVYIEERVKRDDPLSVEQWNSMFNAHGKLQVDVHRVLGIIFHGGI 412

  Fly   390 EKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVVEK 454
            :.||||.||||||..|.:.||.|:|.|:....::||..:.||....:..:....::...:..:||
pombe   413 QPSLRKEVWPFLLSVYPWDSTSEERRVIYLSLQEEYCTLKRKWYEDIHKQFNDRWFIEQRNRIEK 477

  Fly   455 DVVRTDRTNPFFCGDD-------------NPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLC 506
            ||.||||.:.:|..:|             |.|.|:||:|||.:..|:|.:.|.|||||||||:..
pombe   478 DVHRTDRQHEYFQIEDLPHPDPQSTFTGTNMNMEMMKDILLTYNEYDTELGYVQGMSDLLAPIYV 542

  Fly   507 EVQNESETFWCFVGLMQRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFC- 570
            ...:.:.|||..||||:|..|........:...|..||.||..|.|..:.|||:.:.|.  |||
pombe   543 TFNDNALTFWGMVGLMKRLHFNFLRDQSGMHRQLDTLRLLIEFMDPELFAHLEKTDSSN--LFCF 605

  Fly   571 HRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSS 635
            .|.||:.|||||...|::::|:..::|||:..:|:|:..||...:.:.::.|....||:|.:|:.
pombe   606 FRMLLIYFKREFDWEVLLKLWDVLFTNYLSYDYHIFVAYAIAERHREVLLNQTSAFDEVLKYFNE 670

  Fly   636 LAMYMDGQLILRK----ARGLLHQYR------------------------QLPKIPCTLSGLCKR 672
            |:    |:|.|..    |....:|::                        .||.|...|..|.|.
pombe   671 LS----GKLALEPTLICAEQCFYQFKNKLALIDRKQMEETNSDEDGSKETDLPTIAPYLRNLLKT 731

  Fly   673 CGP 675
            ..|
pombe   732 SQP 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	92/244 (38%)
gyp7	NP_592900.1	DUF3548	31..229	CDD:192931	56/321 (17%)
		COG5210	154..739	CDD:227535	144/610 (24%)
		TBC	408..655	CDD:214540	93/248 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I998
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860