DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1D16 and Tbc1d8b

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001074968.1	Gene:	Tbc1d8b / 245638	MGIID:	1918101	Length:	1114	Species:	Mus musculus

Alignment Length:	207	Identity:	51/207 - (24%)
Similarity:	77/207 - (37%)	Gaps:	39/207 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 DLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQ 441
            ||::|      |:.::||..:|..      ||....|.|             |....|:...||.
Mouse   481 DLVVR------GIPETLRGELWML------FSGAVNDMA-------------TNPGYYAEVVEQS 520

  Fly   442 IHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLC 506
            :.........:|:|:.|:...:|.|..|  .....::.:|..:|..|..:.|.|.| ::|..||.
Mouse   521 LGTSNLATEEIERDLRRSLPEHPAFQSD--TGISALRRVLTAYAYRNPKIGYCQAM-NILTSVLL 582

  Fly   507 EVQNESETFWCFVGLMQRA---FFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHN--DSME 566
            ....|.|.||..|.:.:|.   :|........||.  :...||||..||....|:....  .|:.
Mouse   583 LYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQ--AVFEELIRDHLPQLTDHMTDMTFFSSVS 645

  Fly   567 LLFCHRWLLLCF 578
            |    .|.|..|
Mouse   646 L----SWFLTLF 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	48/197 (24%)
Tbc1d8b	NP_001074968.1	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..420
		TBC	485..693	CDD:214540	49/203 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	938..957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900