DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and RABGAP1

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_036329.3	Gene:	RABGAP1 / 23637	HGNCID:	17155	Length:	1069	Species:	Homo sapiens

Alignment Length:	693	Identity:	129/693 - (18%)
Similarity:	206/693 - (29%)	Gaps:	278/693 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SAKRPTLLLT---WIPNSSLCKYT---NLNADDCRGQCNPRSKSPDSRNGYCH-----------V 121
            |||:..|..|   ..|:|.:..::   .:..||.:|..   |..|..::..|.           :
Human   270 SAKQTPLSATAAPQTPDSDIFTFSVSLEIKEDDGKGYF---SAVPKDKDRQCFKLRQGIDKKIVI 331

  Fly   122 TIPQTIQE---------------RDIREEDENAADMQ------------------------ELKN 147
            .:.||..:               :|:|..|.:..|::                        ::.|
Human   332 YVQQTTNKELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVN 396

  Fly   148 ELQP----LLGGQAASIDDLTALLKNNPI-----TSVNITISNPQI--------ENSNISQSFNC 195
            |..|    |....|.   ||.......|:     |.|.:...|.::        ...|.......
Human   397 EETPKDKVLFMTTAV---DLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQ 458

  Fly   196 ITIRPDSNNCSDCTNGSGVGDGPATDNPKWTTPELLAFKHNLE-------------FPDSGN--- 244
            |..|...||               ||    |..|::..:...|             .|.||:
Human   459 IKQRERKNN---------------TD----TLYEVVCLESESERERRKTTASPSVRLPQSGSQSS 504

  Fly   245 ---STPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHYGGLDHL 306
               |.|.|.::..                    ||:...||...: |:|...||       |:..
Human   505 VIPSPPEDDEEED--------------------NDEPLLSGSGDV-SKECAEKI-------LETW 541

  Fly   307 AQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGTLLNEK 371
            .::|.:||..|:                    .||:...|
Human   542 GELLSKWHLNLN--------------------VRPKQLSS------------------------- 561

  Fly   372 GQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSM 436
                   |:|     .|:.::||..||..|..|::.....|...:|          ||::
Human   562 -------LVR-----NGVPEALRGEVWQLLAGCHNNDHLVEKYRIL----------ITKE----- 599

  Fly   437 SPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLL 501
            ||:..         .:.:|:.||...:.:|........:.:..|...::||:..:.|.||.| .|
Human   600 SPQDS---------AITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQS-FL 654

  Fly   502 APVLCEVQNESETFWCFVGLM----QRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKH----- 557
            |.||.....|.:.|...|.:|    .|..|  .....|:......|..|::..:|..|.|
Human   655 AAVLLLHMPEEQAFSVLVKIMFDYGLRELF--KQNFEDLHCKFYQLERLMQEYIPDLYNHFLDIS 717

  Fly   558 LEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFH---LFLCLAIIAVYADDV 619
            ||.|      ::..:|.|..|..:|...:|               ||   |.||..|..::  :|
Human   718 LEAH------MYASQWFLTLFTAKFPLYMV---------------FHIIDLLLCEGISVIF--NV 759

  Fly   620 VAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYR-QLPK 661
            ....|:..:             ..|:|....|.|..:| ||||
Human   760 ALGLLKTSK-------------DDLLLTDFEGALKFFRVQLPK 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	54/242 (22%)
RABGAP1	NP_036329.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		PTB_Rab6GAP	145..273	CDD:269922	2/2 (100%)
		DUF3694	307..437	CDD:403614	19/135 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..527		11/64 (17%)
		TBC	563..772	CDD:214540	57/276 (21%)
		Smc	<823..>1047	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810