DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1D16 and TBC1D30

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_024304669.1	Gene:	TBC1D30 / 23329	HGNCID:	29164	Length:	944	Species:	Homo sapiens

Alignment Length:	362	Identity:	81/362 - (22%)
Similarity:	145/362 - (40%)	Gaps:	94/362 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 GLEKSLRKTVWPFLLKCYSFSSTFE-DRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIV 451
            |:.|..|:.||..|...|..|...: |:.:     |..:.|.:.....||.          :|||
Human   249 GIPKEWRRKVWLTLADHYLHSIAIDWDKTM-----RFTFNERSNPDDDSMG----------IQIV 298

  Fly   452 VEKDVVRTDRTNPFFCGDD-NPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQ--NESE 513
              ||:.||..::  :||.: ..:..|:|.:||.:|.:|..:.|.||. ::||.::.||.  ||.:
Human   299 --KDLHRTGCSS--YCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGF-NILAALILEVMEGNEGD 358

  Fly   514 TFWCFVGLMQR----AFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQ------------HN 562
            .....:.|:.:    ::||.......||  ::..|:|:|:.||...:||:.            :.
Human   359 ALKIMIYLIDKVLPESYFVNNLRALSVD--MAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYE 421

  Fly   563 DSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFH-----LFLCLAIIAVYADDV--- 619
            ..:..:|..:|.|..|........|:::|::.       :|.     |.:.|||.|...:.:
Human   422 PPLTNVFTMQWFLTLFATCLPNQTVLKIWDSV-------FFEGSEIILRVSLAIWAKLGEQIECC 479

  Fly   620 ----------------VAQN--LRPDEMLLHFSSLAMYMDGQLI-LRKARGLLHQYRQLP----K 661
                            :.:|  |:..|::....|:|.:...||. ||:.    :.|...|    .
Human   480 ETADEFYSTMGRLTQEMLENDLLQSHELMQTVYSMAPFPFPQLAELREK----YTYNITPFPATV 540

  Fly   662 IPCTLSGLCKRCGPGMWDSEHRP--------ALECVG 690
            .|.::||...:....  |.|:.|        |:.|:|
Human   541 KPTSVSGRHSKARDS--DEENDPDDEDAVVNAVGCLG 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	61/254 (24%)
TBC1D30	XP_024304669.1	RabGAP-TBC	296..476	CDD:306939	48/193 (25%)
TBC1D30	XP_024304669.1	DUF4682	637..785	CDD:318030
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810