Protein Alignment TBC1D16 and Tbc1d17

DIOPT Version :10

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001036120.1
• Gene: Tbc1d17 / 233204
• MGIID: 2449973
• Length: 645
• Species: Mus musculus
• Alignment Length: 534
• Identity: 138/534 - (25%)
• Similarity: 220/534 - (41%)
• Gaps: 127/534 - (23%)

  Fly   223 PKWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIA 287
            |.|.....:..:.:|..|..|....:.|...|     |||.|.:::|:|.  :....:...||:.
Mouse    86 PDWAVISTVRPQPHLAEPRKGAEPSSSRSSWA-----FSVSLGELKSIRR--SKPGLSWAYLVLV 143

  Fly   288 SRE-SQYKILHFHYGGLDHLAQVLHQW------------------------HCFLH--------- 318
            ::. .....||||.||...|.:||.::                        ..|.|
Mouse   144 TQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQDSRLYLVFPQDPSALSDSFHHLQLFDQDSS 208

  Fly   319 NITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGTL---------------- 367
            |:.|...||.:...:..|                    ...||||.|.|
Mouse   209 NVVSRFLQDPYSTTFSSF--------------------SRVTNFFRGALQPHPEGASSPNLPPLP 253

  Fly   368 ------------------------------------LNEKGQIEDDLLLRKCVFFGGLEKSLRKT 396
                                                :..:|::::...|:..:|.|||...||:.
Mouse   254 DDEPEPGFEVISCVELGQRPTVERAPPVTEEEWNRYVGPEGRLQNVPELKNRIFSGGLSPGLRRE 318

  Fly   397 VWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLY--SMSPEQQ-----IHFWKTVQIVVEK 454
            .|.|||...|:.|:.|:....:   |::.:|..|.:|.  |:|.||:     :|.:::   ::|:
Mouse   319 AWKFLLGYLSWESSAEEHKAHV---RKKTDEYFRMKLQWKSVSAEQERRNSLLHGYRS---LIER 377

  Fly   455 DVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFV 519
            ||.||||||.|:.|.:||...::.:|||.:.:|:..:.|.|||||||:|:|..||||.:.||||.
Mouse   378 DVSRTDRTNKFYEGPENPGLSLLHDILLTYCMYHFDLGYVQGMSDLLSPILFVVQNEVDAFWCFC 442

  Fly   520 GLMQRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTE 584
            |.|:........:...:...|..|..|:|::.......|:. .||..|.||.||||:.|||||..
Mouse   443 GFMELVHGNFEESQETMKRQLGQLLLLLRVLDQPLCDFLDS-QDSGSLCFCFRWLLIWFKREFPF 506

  Fly   585 AVVIRMWEACWSNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKA 649
            ..|:|:||..|:.......||.:..||:.:..|.::......:|:|.|.:.|.|.:..:.:|.:|
Mouse   507 PDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRA 571

  Fly   650 RGLLHQYRQLPKIP 663
            ..|..|....|::|
Mouse   572 EALYRQLTACPELP 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	86/237 (36%)
Tbc1d17	NP_001036120.1	PH_RBD	7..204	CDD:432305	26/124 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..85
		Required for interaction with OPTN. /evidence=ECO:0000250	217..309		11/111 (10%)
		TBC	307..542	CDD:214540	88/241 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..645