DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1D16 and TBC1D9

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_055945.2	Gene:	TBC1D9 / 23158	HGNCID:	21710	Length:	1266	Species:	Homo sapiens

Alignment Length:	305	Identity:	66/305 - (21%)
Similarity:	118/305 - (38%)	Gaps:	80/305 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 DLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRL--YSMSPE 439
            :|:|:      |:.:|:|..:|..|      |....::|.    ....||::..|.:  |:::.|
Human   510 ELVLK------GIPESMRGELWLLL------SGAINEKAT----HPGYYEDLVEKSMGKYNLATE 558

  Fly   440 QQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPV 504
            :           :|:|:.|:...:|.|  .:......::.:|..:|..|..:.|.|.| :::..|
Human   559 E-----------IERDLHRSLPEHPAF--QNEMGIAALRRVLTAYAFRNPNIGYCQAM-NIVTSV 609

  Fly   505 LCEVQNESETFWCFVGLMQRA---FFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSME 566
            |.....|.|.||..|.|.:|.   ::........||..:  ..||.|..:|..|       |.|:
Human   610 LLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGV--FEELARDYVPQLY-------DCMQ 665

  Fly   567 LL-----FCHRWLLLCF--KREFTEAVVIRMWEACWSNYLTDYFH-----LF-LCLAIIAVYADD 618
            .|     ....|.|..|  ...|..|||:          :..:|:     :| |.||::....|.
Human   666 DLGVISTISLSWFLTLFLSVMPFESAVVV----------VDCFFYEGIKVIFQLALAVLDANVDK 720

  Fly   619 VVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQLPKIP 663
            ::  |.:.|...:  :.|..|:|         .:.::...||.||
Human   721 LL--NCKDDGEAM--TVLGRYLD---------SVTNKDSTLPPIP 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	54/248 (22%)
TBC1D9	NP_055945.2	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..456
		TBC	512..722	CDD:214540	56/258 (22%)
		EFh	<893..923	CDD:385324
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1095
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1132..1164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900