DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and TBC1D2B

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001374071.1	Gene:	TBC1D2B / 23102	HGNCID:	29183	Length:	974	Species:	Homo sapiens

Alignment Length:	705	Identity:	128/705 - (18%)
Similarity:	250/705 - (35%)	Gaps:	192/705 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GSIIKKA-SSFILGDERLDRKIDIAY--EDNEILFCKNNVCIHPPT-------IARDESDILHNP 58
            |:.:|.: |||..|....|.:..:.|  |:.|:|         .||       |.::|...|...
Human   224 GNELKNSMSSFRPGRGHNDSRRTVFYTNEEWELL---------DPTPKDLEESIVQEEKKKLTPE 279

  Fly    59 GYLTCTTKTFVDQYN----SAKRPTLLLTWIPNSSLCKYTNLNADDCRGQCNPRSKSPDSRNGYC 119
            |....|...|...:.    ..|||.       ...:..|.|.::..     :|.|:. .|.:|..
Human   280 GNKGVTGSGFPFDFGRNPYKGKRPL-------KDIIGSYKNRHSSG-----DPSSEG-TSGSGSV 331

  Fly   120 HVTIPQTIQERDIREEDENAADMQELKNELQPLLGGQAASIDDLTALL----------------- 167
            .:..|.:..:..::.:.|   ::::||.:|        :|..:|..||
Human   332 SIRKPASEMQLQVQSQQE---ELEQLKKDL--------SSQKELVRLLQQTVRSSQYDKYFTSSR 385

  Fly   168 ---------------KNNPITSVNITISNPQIENSNISQSFNCI----------------TIRPD 201
                           |::.|..:...:....:|..::.|....:                ||:..
Human   386 LCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKESLQQEVRTLKSKVGELNEQLGMLMETIQAK 450

  Fly   202 SNNCSDCTNGSGVGDGP--ATDNPKWTTP------ELLAFKHNLEFPDSGNS------------- 245
            .......:.|.|.|..|  |..:|. ..|      ||...|.||:...:.|.
Human   451 DEVIIKLSEGEGNGPPPTVAPSSPS-VVPVARDQLELDRLKDNLQGYKTQNKFLNKEILELSALR 514

  Fly   246 TPADRQKSAMKCRHFSVD--LSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHYGGL-DHLA 307
            ..|:|::..:..::.|::  |.|:.|             :.:|..:|.:..:.....|.. :.:|
Human   515 RNAERRERDLMAKYSSLEAKLCQIES-------------KYLILLQEMKTPVCSEDQGPTREVIA 566

  Fly   308 QVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITT------------ 360
            |:|..   .|...:.|..:..|..|:   :|...::......|::.:.:|:..
Human   567 QLLED---ALQVESQEQPEQAFVKPH---LVSEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYL 625

  Fly   361 -------------NFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFE 412
                         |:|..| :|.:.....:|   |.:...|:....|..||.:.:..:  :..|:
Human   626 TENQEVSTGVKWENYFAST-VNREMMCSPEL---KNLIRAGIPHEHRSKVWKWCVDRH--TRKFK 684

  Fly   413 DRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVM 477
            |     :.:...::.:.:|.|...:|..:         .:|.|::||...|..:....:...:.:
Human   685 D-----NTEPGHFQTLLQKALEKQNPASK---------QIELDLLRTLPNNKHYSCPTSEGIQKL 735

  Fly   478 KNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGL----MQRAFFVCTPTDRDVDH 538
            :|:||.|:..|..:.|.||::.|:|..|..::.| :.|||.|.:    |.|.::..|.....||.
Human   736 RNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQE-DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQ 799

  Fly   539 NLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEA 593
            .:  .|:|:...||..:.|.||:.....|: ...|.|:.|.......::.::|::
Human   800 RV--FRDLMSEKLPRLHGHFEQYKVDYTLI-TFNWFLVVFVDSVVSDILFKIWDS 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	47/211 (22%)
TBC1D2B	NP_001374071.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		PH_TBC1D2A	36..144	CDD:269966
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..348		15/88 (17%)
		Smc	<338..552	CDD:224117	35/238 (15%)
		RabGAP-TBC	665..876	CDD:366170	46/207 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810