DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBC1D16 and Rabgap1

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001349885.1	Gene:	Rabgap1 / 227800	MGIID:	2385139	Length:	1064	Species:	Mus musculus

Alignment Length:	358	Identity:	81/358 - (22%)
Similarity:	126/358 - (35%)	Gaps:	106/358 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 MVCRPEVKKSEMHPDE------GDVKK------ITTNFFYGTLLNE--------KGQIEDDLLLR 381
            |:..|.....|...||      |||.|      :.|   :|.||::        ..|:..  |:|
Mouse   500 MIPSPPEDDEEEDNDEPLLSGFGDVSKECAEKILET---WGELLSKWHLNLSVRPKQLSS--LVR 559

  Fly   382 KCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWK 446
                 .|:.::||..||..|..|::.....|...:|          ||::     ||:..
Mouse   560 -----SGVPEALRGEVWQLLAGCHNNDHLVEKYRIL----------ITKE-----SPQDS----- 599

  Fly   447 TVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNE 511
                .:.:|:.||...:.:|........:.:..|...::||:..:.|.||.| .||.||.....|
Mouse   600 ----AITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQS-FLAAVLLLHMPE 659

  Fly   512 SETFWCFVGLM----QRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKH-----LEQHNDSMEL 567
            .:.|...|.:|    .|..|  .....|:......|..|::..:|..|.|     ||.|
Mouse   660 EQAFSVLVKIMFDYGLRELF--KQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAH------ 716

  Fly   568 LFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFH---LFLCLAIIAVYADDVVAQNLRPDEM 629
            ::..:|.|..|..:|...:|               ||   |.||..|..::  :|....|:..:
Mouse   717 MYASQWFLTLFTAKFPLYMV---------------FHIIDLLLCEGISVIF--NVALGLLKTSK- 763

  Fly   630 LLHFSSLAMYMDGQLILRKARGLLHQYR-QLPK 661
                        ..|:|....|.|..:| ||||
Mouse   764 ------------DDLLLTDFEGALKFFRVQLPK 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	54/242 (22%)
Rabgap1	NP_001349885.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101
		PTB_Rab6GAP	140..268	CDD:269922
		DUF3694	302..432	CDD:315198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..520		5/19 (26%)
		TBC	558..767	CDD:214540	57/276 (21%)
		ERM	789..1013	CDD:330563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900