DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and Tbc1d16

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_006532756.1	Gene:	Tbc1d16 / 207592	MGIID:	2652878	Length:	782	Species:	Mus musculus

Alignment Length:	782	Identity:	316/782 - (40%)
Similarity:	435/782 - (55%)	Gaps:	117/782 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPIGSIIKKASSFILGDERLDRKID------------IAYEDNEILFCKNNVCIHPPTIARDESD 53
            |.:|.::::|||         :..|            ::..|.|:::.|||||:|.|...:...:
Mouse     1 MSLGRLLRRASS---------KASDLLTLTTGGSGGSLSVLDGEVIYSKNNVCVHAPEGLQGPGE 56

  Fly    54 ILHNPGYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSL-------CKYTNLNADDCRGQCNPRSKS 111
              |:||||....:.  |:...|   ||:|.|:|||.:       .:|....:...|....||.:.
Mouse    57 --HHPGYLCLYMEK--DELLGA---TLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRRRR 114

  Fly   112 PDSRNGYCHVT--------IPQTIQERDIREEDENAADMQELK---NELQPLLGGQAASIDDLTA 165
            ..|.......:        ||   ::.||....:|..|...:.   .:.:.|  .|...:|.  |
Mouse   115 TTSLGALYQPSPTEPRPPLIP---KDEDILVVVQNTQDTAHISPTDEDGEKL--AQGPEVDG--A 172

  Fly   166 LLKNNPITS---VNITISN-----------PQIENSNISQSFNCITIRPDSNNCSD--------C 208
            |..:.|:.|   :..|:|:           |:......|...:...:..||:..||        |
Mouse   173 LSTSQPVHSDSGILSTVSSQDGTEDGREPRPEAVEEEGSLELSADGVSRDSSFDSDSDAFSSPFC 237

  Fly   209 TN--GSGVGDGPAT----------------DNPKWTTPELLAFKHNLEFPDSGNSTPADRQKSAM 255
            .:  .:.:.:|.::                ..||.......:...||.||||.......|.....
Mouse   238 LSPISAALAEGNSSAFLESEGSRQAINCWVGTPKEGISSPSSSDANLRFPDSNGLLQTPRWDEPQ 302

  Fly   256 K-------CRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHYGGLDHLAQVLHQW 313
            :       |..|.|||..||||||||:|:.|||||||:|||||||||.|||:||||.|::|..||
Mouse   303 RGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIFHFHHGGLDKLSEVFQQW 367

  Fly   314 ------HCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGTLLNEKG 372
                  |.....:|.|.       ....|.:.||::..||:||:|...:::..:.:... ||:.|
Mouse   368 KFCTETHLRDQQVTDER-------TCMQFSIRRPKLPSSEIHPEESLYRRLDVSAWLNH-LNDLG 424

  Fly   373 QIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMS 437
            |:|::..||:.:||||::.|:|..||||||..||..||.|:|..|...||:||..|.:||| ||:
Mouse   425 QVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEEREALRSQKRKEYAAIQQKRL-SMT 488

  Fly   438 PEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLA 502
            ||:|..||:.||..|:||||||||.|.||.|:||||.|.|:.||||:||||..:.||||||||:|
Mouse   489 PEEQRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVA 553

  Fly   503 PVLCEVQNESETFWCFVGLMQRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHL-EQHNDSME 566
            |:|.||.:||:||||||||||...||.:|.|.|::..|.|||||:|:....||:|| ....|.::
Mouse   554 PILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQ 618

  Fly   567 LLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAVYADDVVAQNLRPDEMLL 631
            :|||||||||||||||.||..:|:|||||::|.|||||||:|:||:|:|.|||:.|.|..|:|||
Mouse   619 MLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLL 683

  Fly   632 HFSSLAMYMDGQLILRKARGLLHQYRQLPKIPCTLSGLCKRCGPGMWDSEHRPALECVG-HSDDE 695
            ||.:|||:|:|:|:|||||.||:|:|.||:|||:|..|||.||.|||||.:.||:||.| |...|
Mouse   684 HFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSE 748

  Fly   696 KC 697
            .|
Mouse   749 SC 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	139/231 (60%)
Tbc1d16	XP_006532756.1	TBC	439..667	CDD:214540	138/228 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849661
Domainoid	1	1.000	291	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10380
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1170
Isobase	1	0.950	-	0	Normalized mean entropy	S2857
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	1	1.000	-	-		FOG0006347
OrthoInspector	1	1.000	-	-		oto94061
orthoMCL	1	0.900	-	-		OOG6_109412
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3820
SonicParanoid	1	1.000	-	-		X2505
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740