DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBC1D16 and tbc-8

DIOPT Version :9

Sequence 1:	NP_609403.2	Gene:	TBC1D16 / 34431	FlyBaseID:	FBgn0032249	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001255072.1	Gene:	tbc-8 / 176454	WormBaseID:	WBGene00008018	Length:	913	Species:	Caenorhabditis elegans

Alignment Length:	747	Identity:	171/747 - (22%)
Similarity:	282/747 - (37%)	Gaps:	215/747 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SIIKKASSFILGDER---LDRKIDIAYE-----DNEILFCKNNVCIHPPTIARDESDILHNPGYL 61
            ||.::.||.....||   :.|  |..:.     .:.:|:.|||||     :|.:.||..  .||:
Worm   267 SITRQVSSIAASVERNGSVSR--DYVFSLHHSCKSTLLYGKNNVC-----VAMNGSDFA--KGYM 322

  Fly    62 TCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYTNLNADDCRGQCNPRSKSPDSRNG-YCHV---T 122
              :.:.|.|       ..|.|.|:||..:             ..:.:..|..|.|| :.::   |
Worm   323 --SLQKFYD-------GNLSLKWVPNQLM-------------HASSQPSSGHSNNGEFTNIWKNT 365

  Fly   123 IPQTIQERDI-----REEDE---------NAADMQELKNELQPLLGGQ-----AASID-DLTALL 167
            |  .|:.:||     .::||         |...:|....:|.   .||     .:|:: .|..||
Worm   366 I--NIEMQDIIYIHLHQKDEISPTCLTFVNCEGVQSAPFQLP---AGQHSIAFLSSLETGLAPLL 425

  Fly   168 KNNPITSVNIT--------------ISNPQIENSNISQSFNCITIRPDSNNCSDCTNGSGVGDGP 218
            :.:|...|..|              ::||.:    :...|..:             ..|||...|
Worm   426 RLDPPLWVGTTKEKILPRLRKRSTAVANPAM----LDYVFRLV-------------RTSGVEPAP 473

  Fly   219 ATDNPKWTTPELLAFKHNLEFP--DSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTS 281
                            .::|.|  .:.:|.|......::....:.||           |.|:..:
Worm   474 ----------------EDIEDPLAPTSHSPPIHDNCVSLPNSPYIVD-----------NVDSIVN 511

  Fly   282 GQLVIASRESQYKIL-HFHYGGLD---HLAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPE 342
            .|:..|.:..:.:|: ...||.|.   ||..:  :.| .||.:.::|            ::|
Worm   512 FQIGTACQSMRNQIMARAFYGWLTYVRHLRTI--RTH-LLHLVDTKT------------LIC--- 558

  Fly   343 VKKSEMHPDEGDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLE----KSLRKTVWPFLLK 403
                     :.|...:...|:.........:.|.:.|.|  |::.|:|    |.:|:..||:||.
Worm   559 ---------DDDCDPVDEKFWKQARAEPTEENEKEFLKR--VYWRGIEGINTKEVRRMAWPYLLG 612

  Fly   404 CY-----------SFSSTF-----EDRAVLMDIKRQEYEEITRKRL-YSMSP------------- 438
            .:           .|:|.:     |.|.:..:::|::.|.....|. .:.||
Worm   613 LFEWNESPESRLEQFTSQYWQDIEEWRVLEAEVRRRDEEAFRAARARKAASPVREESCDVFEDPN 677

  Fly   439 ----------EQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSY 493
                      |..|..::.....::|||.|.||...||...|  |.|.::.::..:...|....|
Worm   678 EPTCSQHYDRENLITLFRANLHRIDKDVERCDRNLMFFSNKD--NLESLRRVMYTYVRRNLEEGY 740

  Fly   494 SQGMSDLLAPVLCEVQNESETFWCFVGLM--QRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYK 556
            :|||.|||||:|...::|:.|..||..||  ||..|   |....:...|..||.||:::.|..|.
Worm   741 TQGMCDLLAPLLVTFEDEALTLECFSLLMLRQRGKF---PQRPGMSKCLLNLRSLIQVVDPQIYA 802

  Fly   557 HLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNY---LTDYFHLFLCLAIIAVYADD 618
            .:...:.:..|.|..||.||.||||.:.....::||..|:..   :||.|.:|..||.|..|.|.
Worm   803 LISDIDYAQALSFAFRWFLLDFKRELSYECTYKVWEVIWAAQRLRITDDFAIFFGLATITNYHDV 867

  Fly   619 VVAQNLRPDEMLLHFSSLAMYMDGQLILRKAR 650
            ::..|....:|:..|:.:|...|...:|..||
Worm   868 LITNNFDYTDMIKFFNEMAERHDCSRLLSSAR 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	79/279 (28%)
tbc-8	NP_001255072.1	RUN	177..237	CDD:214736
		PH_RUTBC	299..467	CDD:275431	44/218 (20%)
		TBC	670..869	CDD:214540	63/203 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910