Protein Alignment TBC1D16 and tbc-14

DIOPT Version :10

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001317776.1
• Gene: tbc-14 / 174986
• WormBaseID: WBGene00008444
• Length: 630
• Species: Caenorhabditis elegans
• Alignment Length: 704
• Identity: 177/704 - (25%)
• Similarity: 279/704 - (39%)
• Gaps: 178/704 - (25%)

  Fly    17 DERLDRKIDIAYEDNEILFCKNNVCIHPPTIARDESDILHNPGYLTCTTKT---FVDQYNSAKRP 78
            |..||..:.....|..:: |..||.   ..:..|..:.:  ||.|:...|:   |::...|....
 Worm    22 DSDLDSMVRSIVPDKTVI-CVPNVA---AKLGEDSKEYI--PGTLSIVEKSSGVFIEWKPSEDAE 80

  Fly    79 TLLLTWIPNSSLCKYTNLNADDCRGQCNPRSKSPDSRNGYCHVTIPQTIQERDIR---EEDENAA 140
            |   :|:..|.                       |......|...|:..|:...|   ..|.|
 Worm    81 T---SWVMTSD-----------------------DGNTEMVHARSPEEKQKCGARVAFSMDVN-- 117

  Fly   141 DMQELKNELQPLLGGQAASIDDLTALLKNN----PITSVNITISNPQIENSNISQSFNCITIRP- 200
            |:...:|: :|.....:.....:..:.::.    |:...|.|.:    |..:..|.:  ||:|.
 Worm   118 DLSSFRND-EPKRDSGSGGFPSIRLICRDGSSQVPLFFKNTTTA----EFLDRLQGY--ITLRRS 175

  Fly   201 ------------------------DSNNCSDCTNGSGVGD--GPATDNPKWTT----PELLAFKH 235
                                    |.|           ||  .....||..|.    .::.:|..
 Worm   176 HRDSHLVIVVDQKSEALAKSVSMLDEN-----------GDILSRFMQNPYMTAMTGFSKITSFVQ 229

  Fly   236 NLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIASRESQYKILHFHY 300
            :...|...|.|.|..|:..::.         ||.|||                .|.|.::.....
 Worm   230 DQVIPSVLNDTDAVTQEEKIRL---------MRELRL----------------AEEQMRVHSDAA 269

  Fly   301 GGLDHLAQVLHQWHCFLHNITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYG 365
            |..:.:.|:                    :||      .|||:.:      |..|.|...|.|
 Worm   270 GEFEVVTQL--------------------ELP------PRPEIYR------ELPVSKDLWNSF-- 300

  Fly   366 TLLNEKGQIEDDLL--LRKCVFFGGLEKSLRKTVWPFLL---KCYSFSSTFEDRAVLMDIKRQEY 425
            .|.|  |..:...|  |:..||.|||...|||..|..||   :.:...:.|:.|...:   .::|
 Worm   301 KLSN--GSYDPMKLHHLKMNVFRGGLNAELRKEAWKCLLGYRQWHESDTDFQTRRAEL---AKQY 360

  Fly   426 EEITRKRLYSMSPEQQIHFWKTV--QIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYN 488
            |.: :|:..|::.:|:..|.|.|  :.:|||||.|||||.|||.||||.|...:.|:|:.:.:||
 Worm   361 ENM-KKQWMSVTEDQEKRFTKFVKRKSLVEKDVARTDRTVPFFQGDDNVNLVHLHNVLMTYVMYN 424

  Fly   489 TGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLM---QRAFFVCTPTDRD-VDHNLSYLRELIRI 549
            ..:.|.|||||..:|:|..:::|.:|||||||||   |:.|    .||:. :...::.||:|:.|
 Worm   425 FDLGYVQGMSDFASPLLFVMKDEVDTFWCFVGLMELTQKNF----ETDQAFIKLQMNQLRDLVMI 485

  Fly   550 MLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYFHLFLCLAIIAV 614
            :.|....:||... |.::.||.||:|:.|||||:.....::||..||......|.|.:|:||:..
 Worm   486 INPKLANYLESEK-SDDMYFCFRWVLVWFKREFSFLDTCKLWEVLWSGQPCPRFLLLICVAILDS 549

  Fly   615 YADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQ----YRQLPKIPC 664
            ..:.::.......|:|.|.:.|:|::....||..|..:.||    ..:||...|
 Worm   550 QTNIIIDNQFGLTEILKHINDLSMHLKVDEILTAAEAIFHQLSASQNKLPAHIC 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	90/239 (38%)
tbc-14	NP_001317776.1	TBC	320..555	CDD:214540	91/243 (37%)