Protein Alignment TBC1D16 and tbc-2

DIOPT Version :9

• Sequence 1: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_495156.1
• Gene: tbc-2 / 173986
• WormBaseID: WBGene00022880
• Length: 908
• Species: Caenorhabditis elegans
• Alignment Length: 605
• Identity: 124/605 - (20%)
• Similarity: 208/605 - (34%)
• Gaps: 177/605 - (29%)

  Fly    97 NADDCRGQCNPRSKS-PDSRNG-YCHVTIPQ----TIQERDIRE------EDENAADMQELKNEL 149
            |.:|..|..:.||.: |...|| ...|.:|:    .:...|..|      ::||..|:    .||
 Worm   398 NREDLLGSISERSSNIPADANGLVSDVEVPEGILVDVSSVDCEEATRKVLDEENVRDI----GEL 458

  Fly   150 QPLLGGQAASIDDLTALLKNNPITSVN-ITISNPQIENSNISQSFNCITIRPDSNNC-------- 205
            |.|:.|.......|     |..|..:: ||.|....|...|.|:|       |...|
 Worm   459 QDLVEGYRTQNQFL-----NAEIVQLHAITQSLEDREKKLIRQNF-------DLEACYYQLKSRY 511

  Fly   206 --------SDCTNGSGVGDGPATDNPKWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHF-- 260
                    |....|            |...|.:|.     |..:....||.:.|::......|
 Worm   512 LMVLNHFKSPTKPG------------KIMEPGVLK-----ELLEESARTPRESQQNLTDQLGFYK 559

  Fly   261 SVDLSQMRSLRLFFNDDNCT-----SGQLVIASRESQYKILHFHYGGLDHLAQVLHQWHCFLHN- 319
            ..|.|:...|.     |..|     :|.:|.|::..|          .:...:.|..|..||.|
 Worm   560 KDDFSESDDLL-----DTATFYMKKAGDVVEATKLEQ----------SEEYMKWLQSWDAFLVNN 609

  Fly   320 -ITSETGQDKFDLPYRHFMVCRPEVKKSEMHPDEGDVKKITTNFFYGTLLNEKGQIEDDLLLRKC 383
             ::.:|.           ::..|::|                     ||:..
 Worm   610 TVSRQTA-----------IMSSPDLK---------------------TLIRT------------- 629

  Fly   384 VFFGGLEKSLRKTVWPFLLKCYSFSSTFEDRAVLMDIKRQEYEEITRKRLYSMSPEQQIHFWKTV 448
                |:..:.|..||..::     :...:|:..  ::....|:.:.||    ...::|...:...
 Worm   630 ----GVPPAYRGRVWKIIV-----THWVKDKQA--ELGNGYYQSMLRK----AGTKKQDGSYDAA 679

  Fly   449 QIVVEKDVVRTDRTNPFFCGDDNPNTEVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESE 513
            ...::.|:.||..||..|...|:.|.|.::|:|..|..:|:.:.|.||::.|.|..|..: :|.:
 Worm   680 IKQIDLDLARTLPTNKLFDEPDSANIEKLRNVLYAFRYHNSHVGYCQGLNRLAAIALLNL-DEQD 743

  Fly   514 TFW----CFVGLMQRAFFVCTPTDRDVDHNLSYLRELIRIMLPHFYKHLEQHNDSMEL---LFCH 571
            :||    |...|....::..:......|..:  ||:|:...||....||.    ::|:   ||..
 Worm   744 SFWFLVACVEHLQPEGYYTSSLIGAVADQKV--LRDLVAEKLPKLAAHLR----ALEVDLSLFAL 802

  Fly   572 RWLLLCFKREFTEAVVIRMWEACW--SNYLTDYF----------HLFLCLAIIAVYADDVVAQNL 624
            .|.|.||......::.:.:::|..  .|.:...|          |:..|..|..|:.....||
 Worm   803 SWFLTCFVDVLPHSIYLTIFDAFLYEGNKVLFRFALALFKICEPHVLQCKTIGTVHQCLSKAQ-- 865

  Fly   625 RPDEMLLHFSSLAMYMDGQL 644
               |.::.|.|||.....:|
 Worm   866 ---EHIIDFKSLAQVAFNEL 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	55/249 (22%)
tbc-2	NP_495156.1	PH_TBC1D2A	20..119	CDD:269966
		PH	20..111	CDD:278594
		ATG16	235..400	CDD:285778	1/1 (100%)
		DUF1664	<289..368	CDD:285172
		TBC	627..849	CDD:214540	52/256 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810